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Dergiler / Turkish Journal of Biology / 2011 / Cilt: 35 - Sayı: 3

Determination of antimicrobial and antiproliferative activities of the aquatic moss Fontinalis antipyretica Hedw.

Filiz SAVAROĞLU
Cansu Filik İŞÇEN
Ayşe Pınar Öztopcu VATAN
Selda KABADERE
Semra İLHAN
Ruhi UYAR
Sayfa
361–369
Yayın Tarihi
2011-03-01
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

The present study suggests the possibility that Fontinalis antipyretica possesses antimicrobial and anticancer agent(s).

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:The purpose of the current study was to investigate the possible antimicrobial and anticancer properties of the aquatic moss Fontinalis antipyretica Hedw. (Fontinalaceae).
📊
Temel Bulgular & Veri:We first obtained 8 different extracts (methanol; chloroform; acetone; ethyl acetate A, B, C, and D) by two different extraction processes.
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Sonuç & Katkı:The present study suggests the possibility that Fontinalis antipyretica possesses antimicrobial and anticancer agent(s).
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Key words: Activity · antibacterial · antifungal

Özet

The purpose of the current study was to investigate the possible antimicrobial and anticancer properties of the aquatic moss Fontinalis antipyretica Hedw. (Fontinalaceae). We first obtained 8 different extracts (methanol; chloroform; acetone; ethyl acetate A, B, C, and D) by two different extraction processes. The antimicrobial activity of these extracts was then assessed by using the well diffusion method against 8 bacterial and 7 fungal strains. The results of antimicrobial studies showed that extracts of chloroform, acetone, and ethyl acetate A and C were active against almost all the species tested. The most effective extract was C, which was then screened through a preparative TLC (bioautography) for its active components. Spot 4 of extract C exhibited the highest antimicrobial activity against 5 bacterial strains (B. cereus, B. subtilis, E. faecalis, E. aerogenes, and Y. enterocolitica) and 3 fungal strains (A. flavus, F. solani, and F. graminearum), with MIC values of 93.8-375.0 µg/mL and 187.5-375.0 µg/mL, respectively. In addition, in vitro toxicity of the active component of extract C at the concentrations of 0.16, 1.6, 16, 80, and 160 µg/mL was tested. Depending on dose and time, only 80 and 160 µg/mL decreased rat glioma (C6) cell viability after 24 or 48 h. The present study suggests the possibility that Fontinalis antipyretica possesses antimicrobial and anticancer agent(s).

Abstract

The purpose of the current study was to investigate the possible antimicrobial and anticancer properties of the aquatic moss Fontinalis antipyretica Hedw. (Fontinalaceae). We first obtained 8 different extracts (methanol; chloroform; acetone; ethyl acetate A, B, C, and D) by two different extraction processes. The antimicrobial activity of these extracts was then assessed by using the well diffusion method against 8 bacterial and 7 fungal strains. The results of antimicrobial studies showed that extracts of chloroform, acetone, and ethyl acetate A and C were active against almost all the species tested. The most effective extract was C, which was then screened through a preparative TLC (bioautography) for its active components. Spot 4 of extract C exhibited the highest antimicrobial activity against 5 bacterial strains (B. cereus, B. subtilis, E. faecalis, E. aerogenes, and Y. enterocolitica) and 3 fungal strains (A. flavus, F. solani, and F. graminearum), with MIC values of 93.8-375.0 µg/mL and 187.5-375.0 µg/mL, respectively. In addition, in vitro toxicity of the active component of extract C at the concentrations of 0.16, 1.6, 16, 80, and 160 µg/mL was tested. Depending on dose and time, only 80 and 160 µg/mL decreased rat glioma (C6) cell viability after 24 or 48 h. The present study suggests the possibility that Fontinalis antipyretica possesses antimicrobial and anticancer agent(s).

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Bu Makaleye Atıf Yap

SAVAROĞLU, F., İŞÇEN, C. F., VATAN, A. P. Ö., KABADERE, S., İLHAN, S., UYAR, R. (2011). Determination of antimicrobial and antiproliferative activities of the aquatic moss Fontinalis antipyretica Hedw.. Turkish Journal of Biology, Cilt: 35 - Sayı: 3, 361–369. https://ajindex.com/articles/182031

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Kaynakça (13)

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