KaydedilenlerDerginizi ekleyin

Dergiler / Turkish Journal of Biology / 2015 / Cilt: 39 - Sayı: 6

The effects of agomelatine and melatonin on ECoG activity of absenceepilepsy model in WAG/Rij rats

Hatice AYGÜN
Duygu AYDIN
Sema İNANIR
Fatih EKİCİ
Mustafa AYYILDIZ
Erdal AĞAR
Sayfa
904–910
Yayın Tarihi
2015-12-04
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

The repressive effect of agomelatine on the absence seizures was similar to that of the melatonin used in this study.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:The aim of this study was to evaluate the effect of the melatonergic M1 and M2 receptor agonist and serotonergic 5-HT2C receptor antagonist agomelatine on the spike wave discharges (SWDs) seen in electrocorticographic (ECoG) recordings of WAG/Rij rats with absence epilepsy.
📊
Temel Bulgular & Veri:Experimental groups received normal saline (Group I: 1 mL, intraperitoneally (i.p)), agomelatine (Group II: 40 mg/kg, i.p), and melatonin (Group III: 40 mg/kg, i.p) injections for 7 days.
💡
Sonuç & Katkı:The repressive effect of agomelatine on the absence seizures was similar to that of the melatonin used in this study.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Absence epilepsy · agomelatine · melatonin

Özet

The aim of this study was to evaluate the effect of the melatonergic M1 and M2 receptor agonist and serotonergic 5-HT2C receptor antagonist agomelatine on the spike wave discharges (SWDs) seen in electrocorticographic (ECoG) recordings of WAG/Rij rats with absence epilepsy. Twenty-one WAG/Rij male rats were used in this study. Tripolar electrodes were placed on skulls and control ECoG activities were recorded. Experimental groups received normal saline (Group I: 1 mL, intraperitoneally (i.p)), agomelatine (Group II: 40 mg/kg, i.p), and melatonin (Group III: 40 mg/kg, i.p) injections for 7 days. Following this period, 2-h ECoG recordings were repeated. The number of SWDs and their durations were calculated. The total number and duration of SWDs decreased in both the agomelatine and melatonin groups. The systemic administration of agomelatine and melatonin attenuated the genetic absence epilepsy seizures in WAG/Rij rats. The repressive effect of agomelatine on the absence seizures was similar to that of the melatonin used in this study.

Abstract

The aim of this study was to evaluate the effect of the melatonergic M1 and M2 receptor agonist and serotonergic 5-HT2C receptor antagonist agomelatine on the spike wave discharges (SWDs) seen in electrocorticographic (ECoG) recordings of WAG/Rij rats with absence epilepsy. Twenty-one WAG/Rij male rats were used in this study. Tripolar electrodes were placed on skulls and control ECoG activities were recorded. Experimental groups received normal saline (Group I: 1 mL, intraperitoneally (i.p)), agomelatine (Group II: 40 mg/kg, i.p), and melatonin (Group III: 40 mg/kg, i.p) injections for 7 days. Following this period, 2-h ECoG recordings were repeated. The number of SWDs and their durations were calculated. The total number and duration of SWDs decreased in both the agomelatine and melatonin groups. The systemic administration of agomelatine and melatonin attenuated the genetic absence epilepsy seizures in WAG/Rij rats. The repressive effect of agomelatine on the absence seizures was similar to that of the melatonin used in this study.

🔖

Bu Makaleye Atıf Yap

AYGÜN, H., AYDIN, D., İNANIR, S., EKİCİ, F., AYYILDIZ, M., AĞAR, E. (2015). The effects of agomelatine and melatonin on ECoG activity of absenceepilepsy model in WAG/Rij rats. Turkish Journal of Biology, Cilt: 39 - Sayı: 6, 904–910. https://ajindex.com/articles/181577

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (11)

  1. Agar E (2015). The role of cannabinoids and leptin in neurological diseases. Acta Neurol Scand (in press). Aguiar CC, Almeida AB, Araujo PV, Vasconcelos GS, Chaves EM, do Vale OC, Macedo DS, de Sousa FC, Viana GS, Vasconcelos SM (2012). Anticonvulsant effects of agomelatine in mice. Epilepsy Behav 24: 324–328. Antón-Tay F (1974). Melatonin: effects on brain function. Adv Biochem Psychopharmacol 11: 315–324.
  2. Arslan G, Alici SK, Ayyildiz M, Agar E (2013). The role of CB1- receptors in the proconvulsant effect of leptin on penicillininduced epileptiform activity in rats. CNS Neurosci Ther 19: 222–228.
  3. Arslan G, Ayyildiz M, Agar E (2014). The interaction between ghrelin and cannabinoid systems in penicillin-induced epileptiform activity in rats. Neuropeptides 48: 345–352.
  4. Aydın D, Yıldırım M, Ayyıldız M, Ağar E (2013). The effect of combined treatment of alpha-tocopherol, ascorbic acid and pyridoxine with NMDA blocker, memantine on penicillin induced epileptiform activity in rats. Turk J Med Sci 43: 245– 250. Banach M, Gurdziel E, Jedrych M, Borowicz KK (2011). Melatonin in experimental seizures and epilepsy. Pharmacol Rep 63: 1–11.
  5. Barylnik JB, Filippova NV, Trayber LV( 2014). Modern approaches to the synchronization of circadian rhythms in treatment of depression. Zh Nevrol Psikhiatr Im S S Korsakova 114: 124– 128. Bazil CW (2003). Epilepsy and sleep disturbance. Epilepsy Behav 4: 39–45.
  6. Bazil CW, Short D, Crispin D, Zheng W (2000). Patients with intractable epilepsy have low melatonin, which increases following seizures. Neurology 55: 1746–1748.
  7. Beck-Friis J (1985). Serum melatonin in relation to clinical variables in patients with major depressive disorder and a hypothesis of a low melatonin syndrome. Acta Psychiatr Scand 71: 319–330.
  8. Bodinat CD, Lemaitre GB, Mocaer E, Renard P, Muñoz C, Millan MJ (2010). Agomelatine, the first melatonergic antidepressant: discovery, characterization and development. Nat Rev Drug Discov 9: 628–642.
  9. Borowicz KK, Kaminski R, Gasior M, Kleinrok Z, Czuczwar SJ (1999). Influence of melatonin upon the protective action of conventional anti-epileptic drugs against maximal electroshock in mice. Eur Neuropsychopharmacol 9: 185–190.
  10. Cakil D, Yildirim M, Ayyildiz M, Agar E (2011). The effect of coadministration of the NMDA blocker with agonist and antagonist of CB1-receptor on penicillin-induced epileptiform activity in rats. Epilepsy Res 93: 128–133.
  11. Champney TH, Hanneman WH, Legare ME, Appel K (1996). Acute and chronic effects of m