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Dergiler / Turkish Journal of Biology / 2018 / Cilt: 42 - Sayı: 4

Age- and sex-dependent alteration of functions and epigenetic modifications of vessel and endothelium related biomarkers

Sevtap HAN
Muammer Merve AYDIN
Serdar AKANSEL
Suzan Emel USANMAZ
Can AKÇALI
Mecit Orhan ULUDAĞ
Emine DEMİREL YILMAZ
Sayfa
286–296
Yayın Tarihi
2018-08-09
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

These findings could be important for the assessment of vascular status over the course of the life span.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Aging is a main risk factor for development of cardiovascular diseases associated with the impairment of endothelial function in both sexes.
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Temel Bulgular & Veri:Acetylcholine (ACh)-induced relaxations of the aorta were decreased in 3-, 6-, and 12-month-old rats compared to those in 1-month-old female rats.
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Sonuç & Katkı:These findings could be important for the assessment of vascular status over the course of the life span.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Aging · endothelial function · biomarker

Abstract

Aging is a main risk factor for development of cardiovascular diseases associated with the impairment of endothelial function in both sexes. In the present study, age-related changes in vascular responsiveness, epigenetic modifications of vessel wall, and blood biomarkers related to endothelial functions were examined in an age- and sex-dependent manner. Acetylcholine (ACh)-induced relaxations of the aorta were decreased in 3-, 6-, and 12-month-old rats compared to those in 1-month-old female rats. In males, maximum relaxations related to ACh were higher in 1- and 6-month-old rats than in 3- and 12-month-old rats. Plasma levels of nitric oxide (NO) and asymmetric dimethylarginine (ADMA) decreased with age in female rats, and total antioxidant capacity (TAC) and hydrogen sulfide (H2S) levels displayed biphasic alterations. In male rats, plasma levels of NO, TAC, and ADMA decreased with age, and H2S levels increased. Aging also caused a sex-dependent alteration in epigenetic modification of vessels. Expressions of H3K27me2, H3K27me3, H3K36me2, and H3K36me3 were much higher in vessels of 12-month-old female rats compared to those in younger age groups. These results indicate that vascular functions, epigenetic modifications of vessels, and plasma levels of endothelium-related biomarkers are affected by age and sex. These findings could be important for the assessment of vascular status over the course of the life span.

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Bu Makaleye Atıf Yap

HAN, S., AYDIN, M. M., AKANSEL, S., USANMAZ, S. E., AKÇALI, C., ULUDAĞ, M. O., YILMAZ, E. D. (2018). Age- and sex-dependent alteration of functions and epigenetic modifications of vessel and endothelium related biomarkers. Turkish Journal of Biology, Cilt: 42 - Sayı: 4, 286–296. https://ajindex.com/articles/181463

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Kaynakça (13)

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