Dergiler / Haseki Tıp Bülteni / 2019 / Cilt: 57 - Sayı: 3

Incidental Gallbladder Cancer after Laparoscopic Cholecystectomy for Cholelithiasis, and Factors Affecting the Prognosis: A Single-center Experience

Amaç: Cerrahi ve radyolojik yeniliklere rağmen, safra kesesi kanseri (GC) kolesistektomi sonrası patolojik incelemede genellikle rastlantısal olarak teşhis edilir ve rastlantısal GC (IGC) olarak tanımlanır. Yöntemler: Kolesistektomi yapılan hastaları

Sayfa
296–303
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Pathology report on IGC should give information on all histopathological prognostic features in order to avoid loss of time associated with re-examination of specimens due to absence of sufficient information in the initial pathology report and enable the surgical team to perform re-operation for T1b tumors or more advanced IGC in a timely fashion.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Aim: Despite surgical and radiological innovations, gallbladder cancer (GC) is usually diagnosed incidentally by the pathological examination of the cholecystectomy specimens, and it is defined as incidental GC (IGC).
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Temel Bulgular & Veri:Results: We performed cholecystectomy surgery in 6225 patients in 20 years.
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Sonuç & Katkı:Pathology report on IGC should give information on all histopathological prognostic features in order to avoid loss of time associated with re-examination of specimens due to absence of sufficient information in the initial pathology report and enable the surgical team to perform re-operation for T1b tumors or more advanced IGC in a timely fashion.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

Aim: Despite surgical and radiological innovations, gallbladder cancer (GC) is usually diagnosed incidentally by the pathological examination of the cholecystectomy specimens, and it is defined as incidental GC (IGC). Methods: Medical files of patients, who underwent cholecystectomy, were analyzed retrospectively. We investigated the relationship between clinicopathological features and survival in patients with IGC. Results: We performed cholecystectomy surgery in 6225 patients in 20 years. Only 21 patients with IGC were included in this study. The distribution of the tumor stages was as follows: in situ cancer (n=1), T1 (n=2), T2 (n=7), and T3 (n=11). Tumor subtypes were identified as adenocarcinoma (n=16), neuroendocrine tumor (n=2), mucinous carcinoma (n=2), and adenosquamous carcinoma (n=1). Advanced ‘‘T stage’’, conversion of laparoscopic cholecystectomy to open cholecystectomy (OCC), positive surgical margins, positive lymphovascular invasion and increased levels of pre-operative alkaline phosphatase (ALP) were found to be associated with poor survival. Conclusion: In case of OCC or high preoperative ALP activity in cholelithiasis, IGC should be kept in mind. Pathology report on IGC should give information on all histopathological prognostic features in order to avoid loss of time associated with re-examination of specimens due to absence of sufficient information in the initial pathology report and enable the surgical team to perform re-operation for T1b tumors or more advanced IGC in a timely fashion.

Abstract

Amaç: Cerrahi ve radyolojik yeniliklere rağmen, safra kesesi kanseri (GC) kolesistektomi sonrası patolojik incelemede genellikle rastlantısal olarak teşhis edilir ve rastlantısal GC (IGC) olarak tanımlanır. Yöntemler: Kolesistektomi yapılan hastaların tıbbi dosyaları retrospektif olarak incelendi. IGC’de klinikopatolojik özellikler ile sağkalım arasındaki ilişkiyi araştırdık. Bulgular: Yirmi yılda 6225 hastaya kolesistektomi uyguladık. Bu çalışmaya sadece 21 IGC hastası dahil edildi. Tümör evrelerinin dağılımı: in situ kanser (n=1), T1 (n=2), T2 (n=7) ve T3 (n=11) olarak bulundu. Tümör alt tipleri, adenokarsinom (n=16), nöroendokrin tümör (n=2), müsinöz karsinom (n=2), adenoskuamöz karsinom (n=1) olarak tanımlandı. İleri evre T evresi, laparoskopik kolesistektomide açık kolesistektomi dönüş (OCC), pozitif cerrahi sınır, pozitif lenfovasküler invazyon ve preoperatif alkalen fosfatazın (ALP) yüksek aktivitesinin sağkalım süresini kısalttığı saptadık. Sonuç: Kolelitiaziste OCC veya preoperatif ALP’nin yüksek aktivitesi durumunda, IGC’yi aklımızda tutmalıyız. Patologlar, IGC’yi teşhis ettiklerinde tüm histopatolojik prognostik faktörleri içeren bir rapor sunmalıdırlar. Böylece revizyon patolojisi için zaman kaybedilmeyecek, T1b veya daha ileri T-evreleri için reoperasyon uygun zamanda uygulanabilecektir.

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Bu Makaleye Atıf Yap

DEMİRYAS, S., AKINCI, O., KEPİL, N., TAŞÇI, İ. (2019). Incidental Gallbladder Cancer after Laparoscopic Cholecystectomy for Cholelithiasis, and Factors Affecting the Prognosis: A Single-center Experience. Haseki Tıp Bülteni, Cilt: 57 - Sayı: 3, 296–303. https://ajindex.com/articles/172794

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Kaynakça (15)

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