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Dergiler / Journal of Medicine and Palliative Care / 2026 / Volume: 7 Issue: 5

Menopause-specific ROC-based cutoff values for endometrial thickness and the role of heterogeneous endometrial morphology in predicting EIN/endometrial carcinoma

Meryem Bekmezci(AKSARAY UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF SURGICAL MEDICINE, DEPARTMENT OF OBSTETRICS AND GYNECOLOGY)0000-0002-1861-3556
Ramazan Bülbül(AKSARAY UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF SURGICAL MEDICINE, DEPARTMENT OF OBSTETRICS AND GYNECOLOGY)0000-0003-3321-3718
Melike Ordu(AKSARAY UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF SURGICAL MEDICINE, DEPARTMENT OF MEDICAL PATHOLOGY)0000-0001-8863-817X
Sayfa
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Yayın Tarihi
2026-10-25
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Combining menopause-specific cutoff values with endometrial morphology and clinical factors may improve diagnostic accuracy and support individualized clinical decision-making.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Aims: To evaluate the diagnostic value of transvaginal ultrasonography in differentiating benign and malignant endometrial conditions and to determine menopause-specific endometrial thickness cutoff values.
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Temel Bulgular & Veri:Methods: This retrospective study included 6,333 women with abnormal uterine bleeding who underwent transvaginal ultrasonography followed by histopathological evaluation between January 2020 and December 2025.
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Sonuç & Katkı:Combining menopause-specific cutoff values with endometrial morphology and clinical factors may improve diagnostic accuracy and support individualized clinical decision-making.
🔬Tür:Research Article
📍Kapsam:2020 Verileri
⚙️Değişkenler:Endometrium · ultrasonography · uterine hemorrhage

Abstract

Aims: To evaluate the diagnostic value of transvaginal ultrasonography in differentiating benign and malignant endometrial conditions and to determine menopause-specific endometrial thickness cutoff values. Methods: This retrospective study included 6,333 women with abnormal uterine bleeding who underwent transvaginal ultrasonography followed by histopathological evaluation between January 2020 and December 2025. Demographic characteristics, endometrial thickness and morphology, and histopathological findings were recorded. Diagnostic performance was assessed using ROC analysis, optimal cutoff values were determined using the Youden index, and independent predictors were evaluated by multivariable logistic regression. Results: Endometrial thickness was significantly greater in patients with hyperplasia, endometrial intraepithelial neoplasia (EIN), and endometrial carcinoma than in those with benign histopathology (p 12 mm in premenopausal and perimenopausal women and >14.2 mm in postmenopausal women. Increasing age (OR 1.06), endometrial thickness (OR 1.11), postmenopausal status (OR 3.14), and heterogeneous endometrial morphology (OR 10.32) were independent predictors of EIN/endometrial carcinoma. Conclusion: Endometrial thickness is a valuable predictor of EIN/endometrial carcinoma. Combining menopause-specific cutoff values with endometrial morphology and clinical factors may improve diagnostic accuracy and support individualized clinical decision-making.

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Bu Makaleye Atıf Yap

Bekmezci, M., Bülbül, R., Ordu, M. (2026). Menopause-specific ROC-based cutoff values for endometrial thickness and the role of heterogeneous endometrial morphology in predicting EIN/endometrial carcinoma. Journal of Medicine and Palliative Care, Volume: 7 Issue: 5. https://ajindex.com/articles/1668075

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Kaynakça (21)

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