MEFV mutation carriage is frequent in North Cyprus and familial Mediterranean fever might be one of the causes for end stage renal disease in Turkish Cypriots.
📌 3 Maddede Bu Makale
🎯
Amaç & Hipotez:Objectives: This study aims to determine the carrier frequency and the most common mutations of the Mediterranean fever (MEFV) gene in healthy Cypriot population of Turkish origin.Patients and methods: A total of 296 healthy participants (102 males, 194 females; median age 30 years; range 1 to 81 years) were evaluated.
📊
Temel Bulgular & Veri:The exon 2, 3, 5 and 10 of MEFV genes were ampliŞed by polymerase chain reaction.Results: The participants demonstrated an extremely high carrier rate (12.5%).
💡
Sonuç & Katkı:MEFV mutation carriage is frequent in North Cyprus and familial Mediterranean fever might be one of the causes for end stage renal disease in Turkish Cypriots.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri
Abstract
Objectives: This study aims to determine the carrier frequency and the most common mutations of the Mediterranean fever (MEFV) gene in healthy Cypriot population of Turkish origin.Patients and methods: A total of 296 healthy participants (102 males, 194 females; median age 30 years; range 1 to 81 years) were evaluated. The exon 2, 3, 5 and 10 of MEFV genes were ampliŞed by polymerase chain reaction.Results: The participants demonstrated an extremely high carrier rate (12.5%). Most commonly detected mutations were E148Q and A74S, with rates of 7.3% and 2.8%, respectively.Conclusion: Mediterranean fever gene mutation types and carrier rates in Turkish Cypriot population are different than other Mediterranean populations in the region. MEFV mutation carriage is frequent in North Cyprus and familial Mediterranean fever might be one of the causes for end stage renal disease in Turkish Cypriots.
🔖
Bu Makaleye Atıf Yap
GALİP, N., DALKAN, C., TERALI, A., ÇOBANOĞLU, F. N., ÜLGENALP, A., BAHÇECİLER, N., KAVUKÇU, S. (2017). Prevalence of Mediterranean Fever Gene Mutations in Turkish Cypriot Population. art, Cilt: 32 - Sayı: 1, 10–14. https://ajindex.com/articles/165045
Ancient missense mutations in a new member of the RoRet gene family are likely to cause familial Mediterranean fever. The International FMF Consortium. Cell 1997;90:797-807
Tunca M, Akar S, Onen F, Ozdogan H, Kasapcopur O, Yalcinkaya F, et al. Familial Mediterranean fever (FMF) in Turkey: results of a nationwide mu 3. Pras E, Livneh A, Balow JE Jr, Pras E, Kastner DL, Pras M, et al. Clinical differences between North African and Iraqi Jews with familial Mediterranean fever. Am J Med Genet 1998;75:216-9
Heller H, Sohar E, Pras M. Ethnic distribution and amyloidosis in familial Mediterranean fever (FMF). Pathol Microbiol (Basel) 1961;24:718-23
Dalkan C, Galip N, Tekguc H, Cobanoglu N, Bahceciler N. High prevalence of allergy in North Cypriot children. Paediatr Int Child Health 2014;34:37-42
Deltas CC, Mean R, Rossou E, Costi C, Koupepidou P, Hadjiyanni I, et al. Familial Mediterranean fever (FMF) mutations occur frequently in the Greek-Cypriot population of Cyprus. Genet Test 2002;6:15-21
Neocleous V, Costi C, Kyriakou C, Kyriakides TC, Shammas C, Skordis N, et al. Familial Mediterranean fever associated with MEFV mutations in a large cohort of Cypriot patients. Ann Hum Genet 2015;79:20-7
Welin G, Ekelund C. The UN in Cyprus: Swedish Peace-keeping Operations 1964-1993, Hurst & Company; 2004 9. Hussein S. Yesterda y & Today: Turkish Cypriots of Australia; 2007
Connor TM, Oygar DD, Gale DP, Steenkamp R, Nitsch D, Neild GH, et al. Incidence of end-stage renal disease in the Turkish-Cypriot population of Northern Cyprus: a population based study. PLoS One 2013;8:e54394
Feld O, Livneh A, Shinar Y, Berkun Y, Lidar M. MEFV mutation carriage in Israeli Jewish individuals from ethnicities with low risk for familial Mediterranean fever. J Hum Genet 2009;54:369-71
Yalcinkaya F, Duzova A, Gonen S, Özçakar B, Baskın E, Özkaya O, et al. Türk popülasyonun MEFV mutasyonlarının sıklı¤ı. Poster no: 20 IV. National Congress of Transplantation Immunology and Genetics, Çe?me, _____zmir, Turkey; 2013
Yigit S, Karakus N, Tasliyurt T, Kaya SU, Bozkurt N, Kisacik B. Significance of MEFV gene R202Q polymorphism in Turkish familial Mediterranean fever patients. Gene 2012;506:43-5
Cankaya T, Bora E, Torun Bayram M, Ülgenalp A, Kavukçu S, Türkmen MA, et al. Clinical Significance of R202Q Alteration of MEFV Gene in Children With Familial Mediterranean Fever. Arch of Rheum 2015;30:1-5