Dergiler / Yenilikçi Mühendislik ve Doğa Bilimleri / 2023 / Volume: 3 Issue: 2

Detecting acetone from breath using a PrFeO3-doped PANi/TiO2-coated PAN nanofiber sensor for non-invasive diabetic diagnosis

Nesibe Yeşildağ(BURSA TEKNİK ÜNİVERSİTESİ)0009-0007-9008-0604
Ömer Faruk Ünsal(BURSA TEKNİK ÜNİVERSİTESİ)0000-0001-8405-3676
Ayşe Bedeloğlu(BURSA TEKNİK ÜNİVERSİTESİ)0000-0003-2960-5188
Sayfa
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Yayın Tarihi
2023-07-31
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

These findings suggest that PrFeO3-doped nanofibers hold promise as potential candidates for acetone gas sensors in non-invasive diabetes monitoring.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Polyacrylonitrile (PAN) nanofibers doped with varying concentrations of perovskite praseodymium ferrite (PrFeO3) nanoparticles synthesized by calcination were successfully manufactured using a simple electrospinning process.
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Temel Bulgular & Veri:The nanofibers were coated with layers of polyaniline-titanium dioxide (PANi-TiO2) combination using an air brush.
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Sonuç & Katkı:These findings suggest that PrFeO3-doped nanofibers hold promise as potential candidates for acetone gas sensors in non-invasive diabetes monitoring.
🔬Tür:Research Article
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Nanofiber · Acetone · Gas sensor

Abstract

Polyacrylonitrile (PAN) nanofibers doped with varying concentrations of perovskite praseodymium ferrite (PrFeO3) nanoparticles synthesized by calcination were successfully manufactured using a simple electrospinning process. The nanofibers were coated with layers of polyaniline-titanium dioxide (PANi-TiO2) combination using an air brush. The structure, morphology, and electrical characteristics of the nanoparticles and nanofibers were characterized by SEM, FT-IR, and electrical measurement methods. The results indicated that the produced nanofibers exhibited a strong in vitro interaction and selectivity against acetone gas, a biomarker of diabetes. Perovskite nanoparticle doped PAN nanofibers have shown approximately 43% change in resistance with acetone gas exposure. These findings suggest that PrFeO3-doped nanofibers hold promise as potential candidates for acetone gas sensors in non-invasive diabetes monitoring.

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Bu Makaleye Atıf Yap

Yeşildağ, N., Ünsal, Ö. F., Gömeç, R., Bedeloğlu, A. (2023). Detecting acetone from breath using a PrFeO3-doped PANi/TiO2-coated PAN nanofiber sensor for non-invasive diabetic diagnosis. Yenilikçi Mühendislik ve Doğa Bilimleri, Volume: 3 Issue: 2. https://doi.org/10.29228/JIENS.70059

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Kaynakça (83)

  1. Webber S, International Diabetes Federation - Diabetes Atlas, 10th Edition 2021, 2013. https://doi.org/10.1016/j.diabres.2013.10.013.
  2. World Health Organization, Global Report on Diabetes, Isbn. 978 (2016) 88. https://doi.org/ISBN 978 92 4 156525 7.
  3. Baharuddin AA, Ang BC, Haseeb ASMA, Wong YC, Wong YH (2019) Advances in chemiresistive sensors for acetone gas detection. Materials Science in Semiconductor Processing 103 104616 https://doi.org/10.1016/j.mssp.2019.104616.
  4. Shokrekhodaei M and Quinones S (2020) Review of Non-Invasive Glucose Sensing Techniques. Sensors (Switzerland) 1251 https://sci-hub.scihubtw.tw/10.3390/s20051251
  5. Masikini M, Chowdhury M, Nemraoui O (2020) Review—Metal Oxides: Application in Exhaled Breath Acetone Chemiresistive Sensors. Journal of The Electrochemical Society 167 037537 https://doi.org/10.1149/1945-7111/ab64bc.
  6. Rowley WR, Bezold C, Arikan Y, Byrne E, Krohe S (2017) Diabetes 2030: Insights from Yesterday, Today, and Future Trends. Population Health Management 20 6–12 https://doi.org/10.1089/pop.2015.0181.
  7. Jang C, Park JK, Lee HJ, Yun GH, Yook JG (2018) Temperature-corrected fluidic glucose sensor based on microwave resonator. Sensors (Switzerland) 18 1–12 https://doi.org/10.3390/s18113850.
  8. Classification and diagnosis of diabetes: Standards of medical care in Diabetes-2018, Diabetes Care. 41 (2018) S13–S27. https://diabetesjournals.org/care/article/41/Supplement_1/S13/30088/2-Classification-and-Diagnosis-of-Diabetes
  9. Köksal Atış Ş and Önder A (2020) Yeni Tanı Diyabetes Mellitus Hastalarında Sınıflandırma ve Tedavi Yönetimi. Hitit Medical Journal 3 (2020) 62–66
  10. WHO, Use of Glycated Haemoglobin (HbA1c) in the Diagnosis of Diabetes Mellitus: Abbreviated Report of a WHO Consultation. Approved by the Guidelines Review Committee., World Health Organization. (2011) 299–309.
  11. I. Classification, Standards of medical care in diabetes-2014, Diabetes Care. 37 (2014) 14–80. https://doi.org/10.2337/dc14-S014.
  12. Abacı A, Böber E, Büyükgebiz A (2007) Tip 1 Diyabet. Güncel Pediatri 5 1–10 https://dergipark.org.tr/en/pub/pediatri/667492.
  13. Mishra BK (2013) Chemistry of Diabetes and its Impact. Academic Voices: A Multidisciplinary Journal 2 16–22 https://doi.org/10.3126/av.v2i1.8279.
  14. Yuan Y, Chen Z, Zhao X, Sun M, Li Y, Wang Z, Wang C (2017) Continuous Monitoring of Breath Acetone, Blood Glucose and Blood Ketone in 20 Type 1 Diabetic Outpatients Over 30 Days. Journal of Analytical & Bioanalytical Techniques 08 https://doi.org/10.4172/2155-9872.1000386.
  15. Güntner AT, Kompalla JF, Landis H, Theodore SJ, Geidl B, Sievi NA, Kohler M, Pratsinis SE, Gerber PA (2018) Guiding ketogenic diet with breath acetone sensors. Sensors (Switzerland) 18 1–12 https://doi.org/10.3390/s18113655
  16. Wang C, Mbi A, Shepherd M (2010)A study on breath acetone in diabetic patients using a cavity ringdown breath analyzer: Exploring correlations of breath acetone with blood glucose and glycohemoglobin A1C. IEEE Sensors Journal 10 54–63 https://doi.org/10.1109/JSEN.2009.2035730
  17. Musa-Veloso K, Likhodii SS, Rarama E, Benoit S, Liu YMC, Chartrand D, Curtis R, Carmant L, Lortie A, Comeau FJE, Cunnane SC (2006) Breath acetone predicts plasma ketone bodies in children with epilepsy on a ketogenic diet. Nutrition 22 1–8 https://doi.org/10.1016/j.nut.2005.04.008
  18. Puchalska P and Crawford PA (2017) Multi-dimensional Roles of Ketone Bodies in Fuel Metabolism, Signaling, and Therapeutics. Cell Metabolism 25 262–284 https://doi.org/10.1016/j.cmet.2016.12.022
  19. Güntner AT, Sievi NA, Theodore SJ, Gulich T, Kohler M, Pratsinis SE (2017) Noninvasive Body Fat Burn Monitoring from Exhaled Acetone with Si-doped WO3-sensing Nanoparticles. Analytical Chemistry 89 10578–10584 https://doi.org/10.1021/acs.analchem.7b02843
  20. Wang Z and Wang C (2013) Is breath acetone a biomarker of diabetes? A historical review on breath acetone measurements. Journal of Breath Research 7 https://doi.org/10.1088/1752-7155/7/3/037109
  21. Bovey F, Cros J, Tuzson B, Seyssel K, Schneiter P, Emmenegger L, Tappy L (2018) Breath acetone as a marker of energy balance: an exploratory study in healthy humans. Nutrition and Diabetes 8 https://doi.org/10.1038/s41387-018-0058-5
  22. Afreen S and Zhu JJ (2019) Rethinking EBAD: Evolution of smart noninvasive detection of diabetes. TrAC - Trends in Analytical Chemistry 118 477–487 https://doi.org/10.1016/j.trac.2019.06.011
  23. Konvalina G and Haick H (2014) Sensors for Breath Testing: From Nanomaterials to Comprehensive Disease Sensors for Breath Testing: From Nanomaterials to Comprehensive Disease Detection. Accounts of Chemical Research 47 1 66-76 https://doi.org/10.1021/ar400070m
  24. Rydosz A (2018) Sensors for enhanced detection of acetone as a potential tool for noninvasive diabetes monitoring. Sensors (Switzerland) 18 (2018) 1–14 https://doi.org/10.3390/s18072298
  25. Rydosz A (2015) A negative correlation between blood glucose and acetone measured in healthy and type 1 diabetes mellitus patient breath. Journal of Diabetes Science and Technology 9 881–884 https://doi.org/10.1177/1932296815572366
  26. Diskin AM, Španěl P, Smith D (2003) Time variation of ammonia, acetone, isoprene and ethanol in breath: A quantitative SIFT-MS study over 30 days. Physiological Measurement 24 107–119 https://doi.org/10.1088/0967-3334/24/1/308
  27. Wang X, Qin H, Pei J, Chen Y, Li L, Xie J, Hu J (2016)Sensing performances to low concentration acetone for palladium doped LaFeO3 sensors. Journal of Rare Earths 34 704–710. https://doi.org/10.1016/S1002-0721(16)60082-0.
  28. Amann A and Smith D (2013) Volatile Biomarkers: Non-Invasive Diagnosis in Physiology and Medicine. Elsevier. https://doi.org/10.1016/C2012-0-01274-4
  29. Deng C, Zhang J, Yu X, Zhang W, Zhang X (2004) Determination of acetone in human breath by gas chromatography–mass spectrometry and solid-phase microextraction with on-fiber derivatization. Journal of Chromatography B 810 269–275 https://doi.org/10.1016/j.jchromb.2004.08.013
  30. Fergus JW, (2007)Perovskite oxides for semiconductor-based gas sensors. Sensors and Actuators B: Chemical 123 1169–1179 https://doi.org/10.1016/j.snb.2006.10.051
  31. Shankar P and Rayappan JBB (2015) Gas sensing mechanism of metal oxides: The role of ambient atmosphere, type of semiconductor and gases - A review. Science Letters Journal 4 126 http://www.cognizure.com/scilett.aspx?p=200638572
  32. Minh TDC, Blake DR, Galassetti PR (2012) The clinical potential of exhaled breath analysis for diabetes mellitus. Diabetes Research and Clinical Practice 97 195–205. https://doi.org/10.1016/j.diabres.2012.02.006
  33. Miekisch W, Schubert JK, Noeldge-Schomburg GFE (2004) Diagnostic potential of breath analysis - Focus on volatile organic compounds. Clinica Chimica Acta 347 25–39 https://doi.org/10.1016/j.cccn.2004.04.023
  34. Lourenço C and Turner C (2014) Breath Analysis in Disease Diagnosis: Methodological Considerations and Applications. Metabolites 4 465–498 https://doi.org/10.3390/metabo4020465
  35. Li J, Smeeton TM, Zanola M, Barrett J, Berryman-Bousquet V (2018) A compact breath acetone analyser based on an ultraviolet light emitting diode. Sensors and Actuators B: Chemical 273 76–82 https://doi.org/10.1016/j.snb.2018.05.114
  36. Prabhakar A, Quach A, Zhang H, Terrera M, Jackemeyer D, Xian X, Tsow F, Tao N, Forzani ES (2015) Acetone as biomarker for ketosis buildup capability - A study in healthy individuals under combined high fat and starvation diets. Nutrition Journal 14 https://doi.org/10.1186/s12937-015-0028-x
  37. King J, Kupferthaler A, Unterkofler K, Koc H, Teschl S, Teschl G, Miekisch W, Schubert J, Hinterhuber H, Amann A (2009) Isoprene and acetone concentration profiles during exercise on an ergometer Journal of Breath Research 3 027006 https://doi.org/10.1088/1752-7155/3/2/027006
  38. Blaikie TPJ, Edge JA, Hancock G, Lunn D, Megson C, Peverall R, Richmond G, Ritchie GAD, Taylor D (2014) Comparison of breath gases, including acetone, with blood glucose and blood ketones in children and adolescents with type 1 diabetes. Journal of Breath Research 8 046010 https://doi.org/10.1088/1752-7155/8/4/046010
  39. Do JS and Wang SH (2013) On the sensitivity of conductimetric acetone gas sensor based on polypyrrole and polyaniline conducting polymers. Sensors and Actuators B: Chemical 185 39–46 https://doi.org/10.1016/j.snb.2013.04.080
  40. Liu S, Zhang F, Li H, Chen T, Wang Y (2012) Acetone detection properties of single crystalline tungsten oxide plates synthesized by hydrothermal method using cetyltrimethyl ammonium bromide supermolecular template. Sensors and Actuators B: Chemical 162 259–268 https://doi.org/10.1016/j.snb.2011.12.076
  41. Huang Z, Zhang A, Zhang Q, Pan S, Cui D (2019) Electrochemical Biosensor Based on Dewdrop-Like Platinum Nanoparticles-Decorated Silver Nanoflowers Nanocomposites for H 2 O 2 and Glucose Detection. Journal of The Electrochemical Society 166 B1138–B1145 https://doi.org/10.1149/2.0471913JES/XML
  42. Staden RIS, Popa-Tudor I, Ionescu-Tirgoviste C, Stoica RA, Magerusan L (2019) Molecular Enantiorecognition of D- and L-Glucose in Urine and Whole Blood Samples. Journal of The Electrochemical Society 166 B3109–B3115 https://doi.org/10.1149/2.0211909JES/XML
  43. IDF, Eighth edition 2017, 2017. https://www.idf.org/aboutdiabetes/type-2-diabetes.html.
  44. Makaram P, Owens D, Aceros J (2014) Trends in Nanomaterial-Based Non-Invasive Diabetes Sensing Technologies. Diagnostics 4 27–46 https://doi.org/10.3390/diagnostics4020027
  45. Standards of medical care in diabetes-2010, Diabetes Care. 33 (2010). https://doi.org/10.2337/dc10-S011.
  46. Alonso M and Sanchez JM (2013) Analytical challenges in breath analysis and its application to exposure monitoring. TrAC - Trends in Analytical Chemistry 44 78–89 https://doi.org/10.1016/j.trac.2012.11.011
  47. Rooth G and Ostenson S (1966) Acetone in alveolar air, and the control of diabetes. Lancet 2 1102–1105. https://doi.org/10.1016/s0140-6736(66)92194-5
  48. Tassopoulos CN, Barnett D, Fraser TR (1969) Breath-acetone and blood-sugar measurements in diabetes. Lancet 293 1282–1286 https://doi.org/10.1016/s0140-6736(69)92222-3
  49. Kim KH, Jahan SA, Kabir E (2012) A review of breath analysis for diagnosis of human health. TrAC - Trends in Analytical Chemistry 33 1–8 https://doi.org/10.1016/j.trac.2011.09.013
  50. Kupferthaler A, King J, Amann A, Hinterhuber H, Hackner H, Hogl B (2010) Acetone and isoprene concentration profiles in normal human sleep. Memo - Magazine of European Medical Oncology 3 6–7 http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=emed11&NEWS=N&AN=70264318
  51. Saasa V, Malwela V, Beukes M, Mokgotho M, Liu CP, Mwakikunga B (2018) Sensing Technologies for Detection of Acetone in Human Breath for Diabetes Diagnosis and Monitoring. Diagnostics 8 12 https://doi.org/10.3390/diagnostics8010012
  52. Tomer VK, Singh K, Kaur H, Shorie M, Sabherwal P (2017) Rapid acetone detection using indium loaded WO3/SnO2 nanohybrid sensor. Sensors and Actuators B: Chemical 253 703–713 https://doi.org/10.1016/j.snb.2017.06.179
  53. Hung CM, Le DTT, Van Hieu N (2017) On-chip growth of semiconductor metal oxide nanowires for gas sensors: A review. Journal of Science: Advanced Materials and Devices 2 263–285 https://doi.org/10.1016/j.jsamd.2017.07.009
  54. Wong YC, Ang BC, Haseeb ASMA, Baharuddin AA, Wong YH (2020) Review—Conducting Polymers as Chemiresistive Gas Sensing Materials: A Review. Journal of The Electrochemical Society 167 037503 https://doi.org/10.1149/2.0032003jes
  55. Righettoni M, Amann A, Pratsinis SE (2015) Breath analysis by nanostructured metal oxides as chemo-resistive gas sensors. Materials Today 18 163–171 https://doi.org/10.1016/j.mattod.2014.08.017
  56. Korotcenkov G (2007) Metal oxides for solid-state gas sensors: What determines our choice?. Materials Science and Engineering B: Solid-State Materials for Advanced Technology 139 1–23 https://doi.org/10.1016/j.mseb.2007.01.044
  57. Wetchakun K, Samerjai T, Tamaekong N, Liewhiran C, Siriwong C, Kruefu V, Wisitsoraat A, Tuantranont A, Phanichphant S (2011) Semiconducting metal oxides as sensors for environmentally hazardous gases. Sensors and Actuators B: Chemical 160 580–591 https://doi.org/10.1016/j.snb.2011.08.032
  58. Li SM, Zhang LX, Zhu MY, Ji GJ, Zhao LX, Yin J, Bie LJ (2017) Acetone sensing of ZnO nanosheets synthesized using room-temperature precipitation. Sensors and Actuators B: Chemical 249 611–623 https://doi.org/10.1016/j.snb.2017.04.007
  59. Navale ST, Yang ZB, Liu C, Cao PJ, Patil VB, Ramgir NS, Mane RS, Stadler FJ (2018) Enhanced acetone sensing properties of titanium dioxide nanoparticles with a sub-ppm detection limit. Sensors and Actuators B: Chemical 255 1701–1710 https://doi.org/10.1016/j.snb.2017.08.186
  60. Giang HT, Duy HT, Ngan PQ, Thai GH, Thu DTA, Thu DT, Toan NN (2011) Hydrocarbon gas sensing of nano-crystalline perovskite oxides LnFeO 3 (Ln = La, Nd and Sm). Sensors and Actuators B: Chemical 158 246–251 https://doi.org/10.1016/j.snb.2011.06.013
  61. Song P, Wang Q, Zhang Z, Yang Z (2010) Synthesis and gas sensing properties of biomorphic LaFeO3 hollow fibers templated from cotton. Sensors and Actuators B: Chemical 147 248–254 https://doi.org/10.1016/j.snb.2010.03.006
  62. Fan K, Qin H, Wang L, Ju L, Hu J (2013) CO2 gas sensors based on La1-xSrxFeO 3 nanocrystalline powders. Sensors and Actuators B: Chemical 177 265–269 https://doi.org/10.1016/j.snb.2012.11.004
  63. Naseri M and Ghasemi R (2016) Structure and physical properties of Fe6 O8/ba Fe6 O11 nanostructure. Journal of Magnetism and Magnetic Materials 406 200–206 https://doi.org/10.1016/j.jmmm.2016.01.019
  64. Anajafi Z, Naseri M, Neri G (2020) Acetone sensing behavior of p-SmFeO3/n-ZnO nanocomposite synthesized by thermal treatment method. Sensors and Actuators B: Chemical 304 https://doi.org/10.1016/j.snb.2019.127252
  65. Hao P, Lin Z, Song P, Yang Z, Wang Z (2020) Hydrothermal preparation and acetone-sensing properties of Ni-doped porous LaFeO3 microspheres. Journal of Materials Science: Materials in Electronics 31 6679–6689 https://doi.org/10.1007/s10854-020-03224-x
  66. Zhang YH, Li YL, Gong FL, Xie KF, Liu M, Zhang HL, Fang SM (2020) Al doped narcissus-like ZnO for enhanced NO2 sensing performance: An experimental and DFT investigation. Sensors and Actuators B: Chemical 305 127489 https://doi.org/10.1016/j.snb.2019.127489
  67. Ma L, Ma SY, Shen XF, Wang TT, Jiang XH, Chen Q, Qiang Z, Yang HM, Chen H (2018) PrFeO3 hollow nanofibers as a highly efficient gas sensor for acetone detection. Sensors and Actuators B: Chemical 255 2546–2554 https://doi.org/10.1016/j.snb.2017.09.060
  68. Pei S, Ma S, Xu X, Xu X, Almamoun O (2021) Modulated PrFeO3 by doping Sm3+ for enhanced acetone sensing properties. Journal of Alloys and Compounds 856 158274 https://doi.org/10.1016/j.jallcom.2020.158274
  69. Bulut U, Oyku Sayin V, Altin Y, Can Cevher S, Cirpan A, Celik Bedeloglu A, Soylemez S (2023) A flexible carbon nanofiber and conjugated polymer-based electrode for glucose sensing. Microchemical Journal 184 108148. https://doi.org/10.1016/j.microc.2022.108148
  70. Virji S, Huang J, Kaner RB, Weiller BH (2004) Polyaniline nanofiber gas sensors: Examination of response mechanisms. Nano Letters 4 491–496 https://doi.org/10.1021/nl035122e
  71. Ding B, Wang M, Yu J, Sun G (2009) Gas sensors based on electrospun nanofibers. Sensors 9 1609–1624 https://doi.org/10.3390/s90301609
  72. Gupta N, Sharma S, Mir IA, Kumar D (2006) Advances in sensors based on conducting polymers. Journal of Scientific and Industrial Research 65 549–557
  73. Wang Y, Liu A, Han Y, Li T (2020) Sensors based on conductive polymers and their composites: a review. Polymer International 69 7–17 https://doi.org/10.1002/pi.5907
  74. Pirsa S (2017) Chemiresistive gas sensors based on conducting polymers. In Khosrow-Pour M (ed) Materials Science and Engineering: Concepts, Methodologies, Tools, and Applications, Engineering Science Reference, 1–3, pp. 543–574 https://doi.org/10.4018/978-1-5225-1798-6.ch022
  75. Tang P, Xie X, Chen H, Lv C, Ding Y ( 2019) Synthesis of Nanoparticulate PrFeO3 by Sol–Gel Method and its Visible-Light Photocatalytic Activity. Ferroelectrics 546 181–187 https://doi.org/10.1080/00150193.2019.1592470
  76. Jin LN, Shao F, Jin C, Zhang JN, Liu P, Guo MX, Bian SW (2017) High-performance textile supercapacitor electrode materials enhanced with three-dimensional carbon nanotubes/graphene conductive network and in situ polymerized polyaniline. Electrochimica Acta 249 387–394 https://doi.org/10.1016/j.electacta.2017.08.035
  77. Kim NH, Choi SJ, Kim SJ, Cho HJ, Jang JS, Koo WT, Kim M, Kim ID (2016) Highly sensitive and selective acetone sensing performance of WO3 nanofibers functionalized by Rh2O3 nanoparticles. Sensors and Actuators B: Chemical 224 185–192 https://doi.org/10.1016/j.snb.2015.10.021
  78. Tijare SN, Bakardjieva S, Subrt S, Joshi MV, Rayalu SS, Hishita S, Labhsetwar N (2014) Synthesis and visible light photocatalytic activity of nanocrystalline PrFeO 3 perovskite for hydrogen generation in ethanol-water system. Journal of Chemical Sciences 126 517–525 https://doi.org/10.1007/s12039-014-0596-x
  79. Altin Y and Celik Bedeloglu (2021) A Polyacrylonitrile/polyvinyl alcohol-based porous carbon nanofiber electrodes for supercapacitor applications. International Journal of Energy Research 45 16497–16510 https://doi.org/10.1002/ER.6896
  80. Chireh M and Naseri M ( 2019) Effect of calcination temperature on the physical properties of LiFe 5 O 8 nanostructures. Advanced Powder Technology 30 952–960 https://doi.org/10.1016/j.apt.2019.02.009
  81. Zhang H, Xiao J, Chen J, Zhang L, Zhang Y, Jin P (2022) Au modified PrFeO3 with hollow tubular structure can be efficient sensing material for H2S detection. Frontiers in Bioengineering and Biotechnology 10 1–12 https://doi.org/10.3389/fbioe.2022.969870
  82. Mirzaei A, Majhi SM, Kim HW, Kim SS (2022) Metal oxide-based nanofibers and their gas-sensing applications. In Esposito V and MArani D (ed) Metal Oxide-Based Nanofibers and Their Applications, Elsevier, pp. 139–158 https://doi.org/10.1016/B978-0-12-820629-4.00008-4
  83. Konvalina G and Haick H (2014) Sensors for Breath Testing: From Nanomaterials to Comprehensive Disease Sensors for Breath Testing: From Nanomaterials to Comprehensive Disease Detection. Accounts of Chemical Research 47 1 66-76 https://doi.org/10.1021/ar400070m