Dergiler / Pharmata / 2026 / Volume: 6 Issue: 1

SARS-CoV-2'de kullanılan antiviral ilaçların analizi için moleküler baskılı polimer tabanlı elektrokimyasal sensörler: Yenilikler ve son uygulamalar

Molecularly imprinted polymer-based electrochemical sensors for the analysis of antiviral drugs used in SARS-CoV-2: Innovations and recent applications

Fatma Budak(FIRAT ÜNİVERSİTESİ)0000-0001-8935-5171
Ensar Piskin(ANKARA ÜNİVERSİTESİ)0009-0002-0521-6831
Ahmet Cetinkaya(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, GÜLHANE ECZACILIK FAKÜLTESİ, GÜLHANE ECZACILIK PR.)0000-0001-5014-0907
Sayfa
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Yayın Tarihi
2025-12-30
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Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Ayrıca, bu derleme, bu ilaçların analizine ve önümüzdeki yıllarda geliştirilecek yöntemlere ışık tutacaktır.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:Bulaşıcı hastalıklara neden olan virüsler, canlıların sağlığı için hayati bir tehdit oluşturmaktadır.
📊
Temel Bulgular & Veri:Son yıllarda, dünya çapında önemli ölümlere neden olan bulaşıcı bir hastalık olan COVID-19'un tedavisinde, özellikle SARS-CoV-2 olmak üzere antiviral ilaçlar kullanılmaktadır.
💡
Sonuç & Katkı:Ayrıca, bu derleme, bu ilaçların analizine ve önümüzdeki yıllarda geliştirilecek yöntemlere ışık tutacaktır.
🔬Tür:Laboratuvar & Saha Deneyi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Molecularly imprinted polymers · electrochemical sensor · drug analysis

Özet

Bulaşıcı hastalıklara neden olan virüsler, canlıların sağlığı için hayati bir tehdit oluşturmaktadır. Antiviral ilaçlar, bu hastalıkların tedavisinde yaygın olarak kullanılmaktadır. Son yıllarda, bulaşıcı hastalıkların ve küresel salgınların yaygınlığı nedeniyle antiviral ilaçların kullanımı giderek yaygınlaşmaktadır. Son yıllarda, dünya çapında önemli ölümlere neden olan bulaşıcı bir hastalık olan COVID-19'un tedavisinde, özellikle SARS-CoV-2 olmak üzere antiviral ilaçlar kullanılmaktadır. Bu ilaçlar öncelikle virüslerin etkilerini azaltmak, yayılmalarını önlemek ve hastalığı tedavi etmek için kullanılmaktadır. Bu nedenle, MIP tabanlı elektrokimyasal sensörler, antiviral ilaçların hızlı, hassas, güvenilir, kararlı ve en önemlisi seçici bir şekilde tespitini sağlamak için yaygın olarak kullanılmaktadır. Ayrıca, MIP'ler minyatür cihazlara entegre edilebilir, tekrar kullanılabilir ve zorlu koşullar altında bile oldukça kararlı bir yapıya sahiptir. Literatür taraması, MIP tabanlı elektrokimyasal sensörlerin bu önemli avantajlarının, onları antiviral ilaçların seçici ve hassas bir şekilde belirlenmesinde önemli bir avantaj haline getirdiğini ortaya koymaktadır. Bu çalışmada, son yıllarda SARS-CoV-2 enfeksiyonlarının tedavisinde yaygın olarak kullanılan favipiravir, lopinavir, remdesivir, ribavirin ve umifenovir ilaçları için özel olarak tasarlanmış MIP tabanlı elektrokimyasal sensörlerin hem farmasötik hem de biyolojik örneklerdeki uygulamaları, sensör tasarımları ve özellikleri araştırılmıştır. Ayrıca, bu derleme, bu ilaçların analizine ve önümüzdeki yıllarda geliştirilecek yöntemlere ışık tutacaktır.

Abstract

Viruses that cause infectious diseases pose a vital threat to the health of living beings. Antiviral drugs are widely used to treat these diseases. In recent years, due to the prevalence of infectious diseases and global epidemics, the use of antiviral medications has become increasingly widespread. In recent years, antiviral drugs, particularly SARS-CoV-2, have been used in the treatment of COVID-19, an infectious disease that has caused significant deaths worldwide. These drugs are primarily used to reduce the effects of viruses, prevent their spread, and treat the disease. Therefore, MIP-based electrochemical sensors are widely used to provide rapid, sensitive, reliable, stable, and, most importantly, selective detection of antiviral drugs. Furthermore, MIPs can be integrated into miniature devices, are reusable, and possess a highly stable structure even under harsh conditions. A review of the literature reveals that these significant advantages of MIP-based electrochemical sensors have made them a substantial asset in the selective and sensitive determination of antiviral drugs. This study investigates the applications, sensor designs, and properties of MIP-based electrochemical sensors, specifically designed for the drugs favipiravir, lopinavir, remdesivir, ribavirin, and umifenovir, which have been widely used in the treatment of SARS-CoV-2 infections in recent years, in both pharmaceutical and biological samples. Furthermore, this review will shed light on the analysis of these drugs and the methods to be developed in the coming years.

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Bu Makaleye Atıf Yap

Budak, F., Piskin, E., Cetinkaya, A., Özkan, S. A. (2025). SARS-CoV-2'de kullanılan antiviral ilaçların analizi için moleküler baskılı polimer tabanlı elektrokimyasal sensörler: Yenilikler ve son uygulamalar. Pharmata, Volume: 6 Issue: 1. https://doi.org/10.62425/pharmata.1790559

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Kaynakça (42)

  1. Gritsok D, Hedström M, Montenegro MCBSM, Amorim CG. Electrochemical molecularly imprinted polymer sensors in viral diagnostics: Innovations, challenges and case studies. Biosens Bioelectron. 2025;287:117678.
  2. Wang M, Wang W, Chen S, et al. The state-of-the-art of molecularly imprinted polymers based electrochemical sensors and their applications in drug assay. Coord Chem Rev. 2025;526:216384.
  3. Budak F, Piskin E, Cetinkaya A, Ozkan SA. Applications of antiviral drugs with electrochemical sensors. Essential Chem. 2025;1–17.
  4. Tuci S, Mercorelli B, Loregian A. Antiviral drug repurposing: Different approaches and the case of antifungal drugs. Pharmacol Ther. 2025;273:108903.
  5. Cetinkaya A, Kaya SI, Ozkan SA. A comprehensive overview of sensor applications for the diagnosis of SARS-CoV-2 and drugs used in its treatment. Crit Rev Anal Chem. 2023;53:2517–2537.
  6. Mason S, Devincenzo JP, Toovey S, Wu JZ, Whitley RJ. Comparison of antiviral resistance across acute and chronic viral infections. Antiviral Res. 2018;158:103–112.
  7. Rosli NB, Kwon HJ, Jeong JS. Simultaneous quantification method for multiple antiviral drugs in serum using isotope dilution liquid chromatography–tandem mass spectrometry. J Chromatogr B. 2023;1231:123925.
  8. Wagdy HA. A newly developed and validated environmentally friendly RP-HPLC stability-indicating method for molnupiravir: Application to degradation kinetics and LC-MS analysis. Microchem J. 2024;199:109980.
  9. Ramzy S, Abdelazim AH. Application of different spectrophotometric methods for quantitative analysis of direct acting antiviral drugs simeprevir and sofosbuvir. Spectrochim Acta A Mol Biomol Spectrosc. 2022;272:121012.
  10. Gowda JI, Hanabaratti RM, Hipparagi SS. Development of manganese oxide nanoparticles based chemical sensor for sensitive determination of an antiviral drug valaciclovir. Results Chem. 2023;5:100801.
  11. Budak F, Cetinkaya A, Unal MA, Ozkan SA. Design of molecularly imprinted polymer based electrochemical sensor for eco-friendly, selective, and sensitive determination of lincomycin in food samples. Food Chem. 2025;488:144883.
  12. Piskin E, Cetinkaya A, Unal MA, et al. A molecularly imprinted polymer-based detection platform confirmed through molecular modeling for the highly sensitive and selective analysis of ipratropium bromide. J Pharm Biomed Anal. 2024;248:116283.
  13. Malitesta C, Mazzotta E, Picca RA, Poma A, Chianella I, Piletsky SA. MIP sensors: The electrochemical approach. Anal Bioanal Chem. 2012;402(5):1827–1846.
  14. Ma X, Allahou LW, Yang R, et al. Antiviral molecularly imprinted polymers: Engineered precision for multifunctional therapeutic strategies. Mater Sci Eng R Rep. 2026;167:101099.
  15. Belbruno JJ. Molecularly imprinted polymers. Am Chem Soc. 2019;119:1.
  16. Wulff G. Molecular imprinting in cross-linked materials with the aid of molecular templates—A way towards artificial antibodies. Angew Chem Int Ed. 1995;34:1812–1832.
  17. Lowdon JW, Diliën H, Singla P, et al. MIPs for commercial application in low-cost sensors and assays – An overview of the current status quo. Sens Actuators B Chem. 2020;325:128973.
  18. Jian P, Muhammad T, Wei A, Wu B, Zhou T. A membrane-protected micro-solid-phase extraction method based on molecular imprinting and its application to the determination of local anesthetics in cosmetics. J Sep Sci. 2022;45:2675–2686.
  19. Piletska E, Magumba K, Joseph L, et al. Molecular imprinting as a tool for determining molecular markers: A lung cancer case. RSC Adv. 2022;12:17747–17754.
  20. Zhou H, Qiu H, Zhang J, Fang Y, Cui B, Shen Y. Design, preparation, and application of molecularly imprinted nanomaterials for food safety analysis with electrochemistry. Coord Chem Rev. 2024;500:215523.
  21. Liang XH, Yu AX, Bo XJ, Du DY, Su ZM. Metal/covalent-organic frameworks-based electrochemical sensors for the detection of ascorbic acid, dopamine and uric acid. Coord Chem Rev. 2023;497:215427.
  22. Cieplak M, Kutner W. Artificial biosensors: How can molecular imprinting mimic biorecognition? Trends Biotechnol. 2016;34(11):922–941.
  23. Al Faysal A, Cetinkaya A, Erdoğan T, Ozkan SA, Gölcü A. Construction of selective and susceptible MIP-based electrochemical sensors for the determination of fosamprenavir: A comparative study. Electrochim Acta. 2025;512:145516.
  24. Saylan Y, Akgönüllü S, Yavuz H, Ünal S, Denizli A. Molecularly imprinted polymer based sensors for medical applications. Sensors. 2019;19(6):1279.
  25. Herrera-Chacon A, Gonzalez-Calabuig A, Del Valle M. Dummy Molecularly Imprinted Polymers Using DNP as a Template Molecule for Explosive Sensing and Nitroaromatic Compound Discrimination. Chemosensors. 2021;9(9):255. 26. Topcu C, Aydin S, Atasoy BH, Yilmaz RR, Coldur F, Caglar B. Highly selective and sensitive potentiometric determination of favipiravir in COVID-19 antiviral drug formulations. Microchemical J. 2024;205:111390.
  26. Cenikli M, Mullaahmetoglu F, Ozturk R, Ozkan-Ariksoysal D. Does favipiravir interact with DNA? Design of electrochemical DNA nanobiosensor. Talanta. 2025;293:128084.
  27. Patel TK, Patel PB, Barvaliya M, Saurabh MK, Bhalla HL, Khosla PP. Efficacy and safety of lopinavir-ritonavir in COVID-19: A systematic review. J Infect Public Health. 2021;14:740–748.
  28. Mistry S, Zhao J, Alvarez-Baron C, Wu WW, Ismaiel OA. Highlighted: Determination of lopinavir and ritonavir in hERG solution to support in vitro hERG block potency assessment using LC-MS/MS: The challenge of poor drug solubility, Anal Chim Acta., ACA-24-3995.
  29. Li L, Yu X, Xie D, et al. Influence of traditional Chinese medicines on the in vivo metabolism of lopinavir/ritonavir. J Pharm Anal. 2022;12:270–277.
  30. EL-Shorbagy HI, Belal F. Eco-Scale, Blueness, ComplexMoGAPI, and AGREEprep comparison of developed UPLC-fluorescence method with a UPLC-PDA method for remdesivir determination in human plasma. Sustain Chem Pharm. 2025;101965.
  31. Paul K, Gowda BHJ, Chandan RS. Development and validation of a novel RP-HPLC method for determination of Remdesivir: Investigation of the greenness for the proposed method. Results Chem. 2025;16:102382.
  32. Wang Z, Ji Y, You N, Hu X, Du F, Liu G. Nanoconfinement-enhanced electrochemiluminescence for ribavirin detection. J Electroanal Chem. 2025;994:119274.
  33. Danso D, Langman LJ, Snozek CLH. LC–MS/MS quantitation of ribavirin in serum. Clin Chim Acta. 2011;412:2332–2335.
  34. Volkova TV, Simonova OR, Perlovich GL. Cyclodextrin effects on the distribution, solubility and transport properties of umifenovir. Colloids Surf A Physicochem Eng Asp. 2025;705:135574.
  35. Ul’yanovskii NV, Kosyakov DS, Sypalov SA, Varsegov IS, Shavrina IS, Lebedev AT. Cyclodextrin effects on the distribution, solubility and transport properties of umifenovir. Colloids and Surfaces A Physicochemical and Engineering Aspects. 2024;705(24):135574.
  36. Shu R, Tian S, Qu W, et al. Hepatoprotective drug screening identifies daclatasvir as a therapeutic candidate for MASLD. J Lipid Res. 2025;66(7).
  37. Yamani HZ, El Azab NF. First electropolymerized carbidopa-based molecularly imprinted film for favipiravir monitoring. Microchem J. 2024;196:109572.
  38. Al Faysal A, Cetinkaya A, Erdoğan T, Ozkan SA, Gölcü A. Comparative study of two MIP-based electrochemical sensors for selective detection and quantification of the antiretroviral drug lopinavir in human serum. Talanta. 2025;285:126791.
  39. Wisnuwardhani HA, Ibrahim S, Mukti RR, Damayanti S. Computational and experimental investigation on functional monomer selection for a molecularly imprinted polymer of remdesivir. J Mol Liq. 2024;414:126023.
  40. Gao H, You J, Wu H, Tian M. Dual-action electrochemical molecular imprinting sensor for ribavirin detection. Food Chem. 2025;473:143092.
  41. Cetinkaya A, Unal MA, Nazır H, Çorman ME, Uzun L, Ozkan SA. Development of borazine-assisted-oriented molecularly imprinted electrochemical sensor for the detection of umifenovir in serum and urine by EIS and DPV methods. Sens Actuators B Chem. 2024;420:136519.
  42. El Azab NF, El-Mosallamy SS, Mahmoud AM, Trabik YA. Core–shell molecularly imprinted polymer for selective detection of daclatasvir. Microchem J. 2025;113723.