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Dergiler / Sakarya University Journal of Science / 2016 / Volume: 20 Issue: 3

Kinesin-5 inhibitörü olan Monastrol bileşiğinin sentezi ve yük transferi kompleks etkileşmelerinin incelenmesi

Synthesis of Monastrol, Kinesin-5 inhibitör and ınvestigation of its charge transfer complexes

Mustafa Arslan
Nurcan Berber
Sayfa
—
Yayın Tarihi
2016-12-01
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Komplekslerin denge sabiti Benesi-Hildebrand ve termodinamik parametreleri Van't Hoff denklemi ile belirlenmiştir.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Kinesin-5 inhibitörü olarak kullanılan Monastrol, çözücüsüz ortamda alümina sülfonik asit (ASA) katalizörü varlığında 3-hidroksibenzaldehit, tiyoüre ve etilasetoasetat kullanılarak sentezlenmiştir.
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Temel Bulgular & Veri:Elektron verici (Donör, D) olarak monastrol, elektron alıcı (Akseptör, A) olarak tetrasiyanoquinometan (TCNQ) kullanılmış ve bunlar ile 2,3-dikloro-5,6-disiyano-p-benzokinon (DDQ) bileşikleri arasındaki yük transfer kompleksleri asetonitril içinde 21 °C'de spektrofotometrik olarak incelenmiştir.
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Sonuç & Katkı:Komplekslerin denge sabiti Benesi-Hildebrand ve termodinamik parametreleri Van't Hoff denklemi ile belirlenmiştir.
🔬Tür:Research Article
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Spectrophotometer · charge transfer complexes · monastrol

Özet

Kinesin-5 inhibitörü olarak kullanılan Monastrol, çözücüsüz ortamda alümina sülfonik asit (ASA) katalizörü varlığında 3-hidroksibenzaldehit, tiyoüre ve etilasetoasetat kullanılarak sentezlenmiştir. Elektron verici (Donör, D) olarak monastrol, elektron alıcı (Akseptör, A) olarak tetrasiyanoquinometan (TCNQ) kullanılmış ve bunlar ile 2,3-dikloro-5,6-disiyano-p-benzokinon (DDQ) bileşikleri arasındaki yük transfer kompleksleri asetonitril içinde 21 °C'de spektrofotometrik olarak incelenmiştir. Komplekslerin stokiyometrisi, Job yöntemi kullanılarak incelenmiş, elektron verici ve alıcılar arasında TCNQ ile 742 nm ve DDQ ile 546 nm dalga boyunda maksimum absorbsiyon bandında 1:1 oranında olduğu bulunmuştur. Komplekslerin denge sabiti Benesi-Hildebrand ve termodinamik parametreleri Van't Hoff denklemi ile belirlenmiştir.

Abstract

Monastrol which is a kinesin-5 inhibitor have been synthesized using 3-hydroxybenzaldehyde, thiourea and ethylasetoasetate in the presence of Alumina Sulphonic Acid (ASA) catalyst in solvent free system. Charge transfer complexes between monastrol as a donor and acceptors such as tetracyanoquinomethane (TCNQ) and 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) have been studied spectrophotometrically in acetonitrile at 21 o C. The stoichiometry of the complexes was found to be 1:1 ratio by the Job method between donor and acceptors with the maximum absorption band at a wavelength of 742nm and 546nm respectively. The equilibrium constants were determined by Benesi-Hildebrand and thermodynamic parameters of the complexes by Van’t Hoff equation.

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Bu Makaleye Atıf Yap

Arslan, M., Berber, N. (2016). Kinesin-5 inhibitörü olan Monastrol bileşiğinin sentezi ve yük transferi kompleks etkileşmelerinin incelenmesi. Sakarya University Journal of Science, Volume: 20 Issue: 3. https://doi.org/10.16984/saufenbilder.67697

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