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Dergiler / Sakarya University Journal of Science / 2022 / Volume: 26 Issue: 6

Synthesis, DPPH and ABTS Activity of Novel Furfuryl-Chalcone Derivatives

Fatih Sönmez(SAKARYA UYGULAMALI BİLİMLER ÜNİVERSİTESİ)0000-0001-7486-6374
Enes Akgün(SAKARYA ÜNİVERSİTESİ, FEN BİLİMLERİ ENSTİTÜSÜ)0000-0002-2293-925X
Zuhal Şahin(SAKARYA UYGULAMALI BİLİMLER ÜNİVERSİTESİ)0000-0001-9856-8064
Sayfa
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Yayın Tarihi
2022-12-31
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

The structure-activity relationship results revealed that most of synthesized sulfonyl chloride derivatives (4a-e) have higher antioxidant activity than the sulphonamide derivatives (5a-c) and also 4d and 4e, including hydroxyl group, exhibited the strongest antioxidant activity as expected.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:In this study, novel furfuryl-chalcone derivatives substituted sulfonyl chloride or sulphonamide were synthesized.
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Temel Bulgular & Veri:Among them, (E)-5-(3-(4-(chlorosulfonyl)-3-hydroxyphenyl)-3-oxoprop-1-en-1-yl)furan-2-sulfonyl chloride (4e) and (E)-5-(3-(3-(chlorosulfonyl)-4-hydroxyphenyl)-3-oxoprop-1-en-1-yl)furan-2-sulfonyl chloride (4d) exhibited the highest DPPH activity with the IC50 values of 4.23 μM and 6.68 μM, respectively, which are almost 2- and 1.5-fold more than quercetin activity (IC50 = 8.69 μM), well-known as antioxidant agent and used as a standard.
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Sonuç & Katkı:The structure-activity relationship results revealed that most of synthesized sulfonyl chloride derivatives (4a-e) have higher antioxidant activity than the sulphonamide derivatives (5a-c) and also 4d and 4e, including hydroxyl group, exhibited the strongest antioxidant activity as expected.
🔬Tür:Research Article
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Antioxidant activity · chalcone · furan

Abstract

In this study, novel furfuryl-chalcone derivatives substituted sulfonyl chloride or sulphonamide were synthesized. Their antioxidant properties were investigated via DPPH and ABTS assays. All furfuryl-chalcones had high antioxidant properties. Among them, (E)-5-(3-(4-(chlorosulfonyl)-3-hydroxyphenyl)-3-oxoprop-1-en-1-yl)furan-2-sulfonyl chloride (4e) and (E)-5-(3-(3-(chlorosulfonyl)-4-hydroxyphenyl)-3-oxoprop-1-en-1-yl)furan-2-sulfonyl chloride (4d) exhibited the highest DPPH activity with the IC50 values of 4.23 μM and 6.68 μM, respectively, which are almost 2- and 1.5-fold more than quercetin activity (IC50 = 8.69 μM), well-known as antioxidant agent and used as a standard. Also, 4e and 4d had the highest ABTS activity with the IC50 value of 5.55 μM and 7.84 μM, respectively, which are almost 2.8- and 2-fold higher than that of quercetin (IC50 = 15.49 μM). The structure-activity relationship results revealed that most of synthesized sulfonyl chloride derivatives (4a-e) have higher antioxidant activity than the sulphonamide derivatives (5a-c) and also 4d and 4e, including hydroxyl group, exhibited the strongest antioxidant activity as expected.

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Bu Makaleye Atıf Yap

Sönmez, F., Akgün, E., Şahin, Z. (2022). Synthesis, DPPH and ABTS Activity of Novel Furfuryl-Chalcone Derivatives. Sakarya University Journal of Science, Volume: 26 Issue: 6. https://ajindex.com/articles/1638230

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