In this review, we carried out the interaction between non-small cell lung cancer and its microenvironment to point out the significance of the tumor environment
📌 3 Maddede Bu Makale
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Amaç & Hipotez:As in all living cells, cancer cells are evaluating is very important in the frames of tumor development and treatment.
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Temel Bulgular & Veri:As in all evolutionary process, the environment of living cells has an important role.
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Sonuç & Katkı:In this review, we carried out the interaction between non-small cell lung cancer and its microenvironment to point out the significance of the tumor environment
🔬Tür:Literatür & Derleme Çalışması
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Tumor Microenvironment · Non-Small Cell Lung Cancer · Extracellular Matris
Abstract
As in all living cells, cancer cells are evaluating is very important in the frames of tumor development and treatment. As in all evolutionary process, the environment of living cells has an important role. Tumor cells have an environment is called tumor microenvironment, affects the therapeutic response and clinical results. Tumor microenvironments involve various cell types, extracellular matrix substances that are in the niche of cancer cells. The microenvironment is not only important in tumorigenesis but it is effective on therapeutic efficacy. In this review, we carried out the interaction between non-small cell lung cancer and its microenvironment to point out the significance of the tumor environment
SEVER, T., LEBLEBİCİ, A., KOC, A., BİNİCİER, C., OLGUN, A., EDİZER, D. T., ÖZDEMİR, T. R., SERİN, G., ERDEM, M., BASBİNAR, Y. (2019). New Insight of Tumor Microenvironment in Non-Small Cell Lung Cancer. Journal of Basic and Clinical Health Sciences, Cilt: 3 - Sayı: 2, 113–120. https://ajindex.com/articles/163627
Ahmad A, Gadgeel SM. Lung Cancer and Personalized Medicine: Novel Therapies and Clinical Management. Preface. Adv Exp Med Biol. 2016
v-vi. [CrossRef] Donnem T, Andersen S, Al-Saad S, Al-Shibli K, Busund LT, Bremnes RM. Prognostic impact of angiogenic markers in non-small-cell lung cancer is related to tumor size. Clin Lung Cancer 2011
j.cllc.2011.03.00 Wood SL, Pernemalm M, Crosbie PA, Whetton AD. The role of the tumor-microenvironment in lung cancer-metastasis and its relationship to potential therapeutic targets. Cancer Treat Rev 2014
558–566. [CrossRef] Kinoshita T, Ishii G, Hiraoka N, et al. Forkhead box P3 regulatory T cells coexisting with cancer associated fibroblasts are correlated with a poor outcome in lung adenocarcinoma. Cancer Sci 2013
409– 415. [CrossRef] Paulsson J, Micke P. Prognostic relevance of cancer-associated fibroblasts in human cancer. Sem Cancer Biol 2014
61–68. [CrossRef] Ma J, Liu L, Che G, Yu N, Dai F, You Z. The M1 form of tumor- associated macrophages in non-small cell lung cancer is positively associated with survival time. BMC Cancer 2010
[CrossRef] Dieu-Nosjean MC, Antoine M, Danel C, et al. Long-term survival for patients with non-small-cell lung cancer with intratumoral lymphoid structures. J Clin Oncol 2008
4410–4417. [CrossRef] Chaisemartin L, Goc J, Damotte D, et al. Characterization of chemokines and adhesion molecules associated with T cell presence in tertiary lymphoid structures in human lung cancer. Cancer Res 2011
6391–6399. [CrossRef] Goc J, Germain C, Vo-Bourgais TKD, et al. Dendritic cells in tumor- associated tertiary lymphoid structures signal a th1 cytotoxic immune contexture and license the positive prognostic value of infiltrating CD8+ t cells. Cancer Res 2014
705–715. [CrossRef] Remark R, Alifano M, Cremer I, et al. Characteristics and clinical impacts of the immune environments in colorectal and renal cell carcinoma lung metastases: Influence of tumor origin. Clin Cancer Res 2013
4079–4091. [CrossRef] Zou W. Regulatory T cells, tumour immunity and immunotherapy. Nat Rev Immunol 2006
295–307. [CrossRef] Wald O, Shapira OM, Izhar U. CXCR4/CXCL12 axis in non small cell lung cancer (NSCLC) pathologic roles and therapeutic potential. Theranostics 2013
26–33. [CrossRef] Kirshberg S, Izhar U, Amir G, et al. Involvement of CCR6/CCL20/ IL-17 axis in NSCLC disease progression. PLoS One 2011
e24856. [CrossRef] Ramalingam SS, Owonikoko TK, Khuri FR. Lung cancer