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Dergiler / Journal of Basic and Clinical Health Sciences / 2019 / Cilt: 3 - Sayı: 2

Limitations of Cross-Talk Between Osteosarcoma and Bone Marrow-Derived Mesenchymal Stem Cells

Yasemin BASBİNAR
Tugba UYSAL
Caner KARACA
Ezgi DASKİN
Hanife Ecenur MECO
Ahu PAKDEMİRLİ
Turkan YİGİTBASİ
Hulya ELLİDOKUZ
Sayfa
83–88
Yayın Tarihi
2019-06-01
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Mann Whitney U Test was used to compare independent samples.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Objectives: Metastasis is a multi-step process which leads the tumor cells to escape from primer tumor region due to their need to gain malign phenotypes.
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Temel Bulgular & Veri:Cross-talk via soluble factors also shifts the metastatic character.Patients and Methods: In this study, the effects of mesenchymal stem cells on tumor behavior by creating different microenvironments in 3-dimensional 3D in vitro cancer model is analyzed.
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Sonuç & Katkı:Mann Whitney U Test was used to compare independent samples.
🔬Tür:Modelleme & Sayısal Simülasyon
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Osteosarcoma · MG-63 · BM-MSCs

Abstract

Objectives: Metastasis is a multi-step process which leads the tumor cells to escape from primer tumor region due to their need to gain malign phenotypes. While the effect of bone marrow-derived mesenchymal stem cells upon metastasis is not certain, some studies point out bone marrow-derived mesenchymal stem cells BM-MSCs to have this ability due to cell-cell interaction, released cytokines, and organization with the extracellular matrix in the micro-environment. Cross-talk via soluble factors also shifts the metastatic character.Patients and Methods: In this study, the effects of mesenchymal stem cells on tumor behavior by creating different microenvironments in 3-dimensional 3D in vitro cancer model is analyzed. The BM-MSCs and osteosarcoma cells were co-cultured via hanging-drop modeled 3D structure in normoxic and hypoxic conditions, and the cross-talk was modeled to measure their chemoattractant effects. The invasion and migration rates were measured with xCELLigence DP real-time cell analysis system. Mann Whitney U Test was used to compare independent samples. All P-values

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Bu Makaleye Atıf Yap

BASBİNAR, Y., UYSAL, T., KARACA, C., DASKİN, E., MECO, H. E., PAKDEMİRLİ, A., YİGİTBASİ, T., ELLİDOKUZ, H. (2019). Limitations of Cross-Talk Between Osteosarcoma and Bone Marrow-Derived Mesenchymal Stem Cells. Journal of Basic and Clinical Health Sciences, Cilt: 3 - Sayı: 2, 83–88. https://ajindex.com/articles/163621

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Kaynakça (3)

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