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Dergiler / Journal of Basic and Clinical Health Sciences / 2021 / Cilt: 5 - Sayı: 1

Organoid As a Novel Technology for Disease Modeling

Tolga SEVER
Ilgin CEVIK
Gizem ÇALIBAŞI KOÇAL
Ender Berat ELLİDOKUZ
Yasemin BAŞBINAR
Sayfa
94–101
Yayın Tarihi
2021-02-26
DOI
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Yapay Zeka Hızlı Bakış & Çıkarımlar

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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

The review describes the recent development of organoid disease modeling approaches.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:The organoid technology is capable to create more real-like in vitro models in terms of structure and function of the origin of the tissue.
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Temel Bulgular & Veri:Since the three-dimensional model is able to illustrate disease pathology, cell differentiation, and recapitulation of self-renewal, lead organoid technology as a promising disease model to fill the gap between conventional two-dimensional, and in vivo disease models.
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Sonuç & Katkı:The review describes the recent development of organoid disease modeling approaches.
🔬Tür:Literatür & Derleme Çalışması
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Organoid · Disease modeling · Stem cell

Abstract

The organoid technology is capable to create more real-like in vitro models in terms of structure and function of the origin of the tissue. Since the three-dimensional model is able to illustrate disease pathology, cell differentiation, and recapitulation of self-renewal, lead organoid technology as a promising disease model to fill the gap between conventional two-dimensional, and in vivo disease models. The review describes the recent development of organoid disease modeling approaches.

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Bu Makaleye Atıf Yap

SEVER, T., CEVIK, I., KOÇAL, G. Ç., ELLİDOKUZ, E. B., BAŞBINAR, Y. (2021). Organoid As a Novel Technology for Disease Modeling. Journal of Basic and Clinical Health Sciences, Cilt: 5 - Sayı: 1, 94–101. https://ajindex.com/articles/163464

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Kaynakça (16)

  1. Duval K, Grover H, Han LH, Mou Y, Pegoraro AF, Fredberg J, et al. Modeling physiological events in 2D vs. 3D cell culture. Physiology. 2017
  2. Byrne AT, Alférez DG, Amant F, Annibali D, Arribas J, Biankin A V., et al. Interrogating open issues in cancer precision medicine with patient-derived xenografts. Nature Reviews Cancer. 2017
  3. Haycock JW. 3D cell culture: a review of current approaches and techniques. Methods in molecular biology (Clifton, N.J.). 2011
  4. Mahe MM, Aihara E, Schumacher MA, Zavros Y, Montrose MH, Helmrath MA, et al. Establishment of Gastrointestinal Epithelial Organoids. Curr Protoc Mouse Biol. 2013
  5. Takebe T, Sekine K, Enomura M, Koike H, Kimura M, Ogaeri T, et al. Vascularized and functional human liver from an iPSC-derived organ bud transplant. Nature. 2013
  6. Schreurs RRCE, Baumdick ME, Sagebiel AF, Kaufmann M, Mokry M, Klarenbeek PL, et al. Human Fetal TNF-α-Cytokine-Producing CD4 + Effector Memory T Cells Promote Intestinal Development and Mediate Inflammation Early in Life. Immunity. 2019
  7. Noel G, Baetz NW, Staab JF, Donowitz M, Kovbasnjuk O, Pasetti MF, et al. A primary human macrophage-enteroid co-culture model to investigate mucosal gut physiology and host-pathogen interactions. Sci Rep. 2017
  8. Koike H, Iwasawa K, Ouchi R, Maezawa M, Giesbrecht K, Saiki N, et al. Modelling human hepato-biliary-pancreatic organogenesis from the foregut–midgut boundary. Nature. 2019
  9. Fujii M, Matano M, Nanki K, Sato T. Efficient genetic engineering of human intestinal organoids using electroporation. Nat Protoc. 2015
  10. Dutta D, Heo I, Clevers H. Disease Modeling in Stem Cell-Derived 3D Organoid Systems. Trends in Molecular Medicine. 2017
  11. Liu B, Song Y, Liu D. Recent development in clinical applications of PD-1 and PD-L1 antibodies for cancer immunotherapy. Journal of Hematology and Oncology. 2017
  12. Pang Y, Hou X, Yang C, Liu Y, Jiang G. Advances on chimeric antigen receptor-modified T-cell therapy for oncotherapy. Molecular Cancer. 2018
  13. Zhou J, Su J, Fu X, Zheng L, Yin Z. Microfluidic device for primary tumor spheroid isolation. Exp Hematol Oncol. 2017
  14. Ben-David U, Ha G, Tseng YY, Greenwald NF, Oh C, Shih J, et al. Patient-derived xenografts undergo mouse-specific tumor evolution. Nat Genet. 2017
  15. Na JC, Kim JH, Kim SY, Gu YR, Jun DY, Lee HH, et al. Establishment of patient-derived three-dimensional organoid culture in renal cell carcinoma. Investig Clin Urol. 2020
  16. Van De Wetering M, Francies HE,