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Dergiler / Interdisciplinary Medical Journal / 2026 / Volume: 15 Issue: 52

Clinical significance of mean platelet volume, platelet distribution width, and neutrophil-lymphocyte ratio in children with familial mediterranean fever

Gül Trabzon(HATAY MUSTAFA KEMAL ÜNİVERSİTESİ, TAYFUR ATA SÖKMEN TIP FAKÜLTESİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, ÇOCUK SAĞLIĞI VE HASTALIKLARI ANABİLİM DALI, ÇOCUK ENDOKRİNOLOJİSİ BİLİM DALI)0000-0002-9262-5678
Müferet Ergüven(DUZCE UNIVERSITY)0000-0002-3255-1208
Didem Kızmaz İşançlı(3. Ok Meydanı Training and Research Hospital Department of Pediatric Infection)0000-0002-0791-5903
Emine Olcay Yasa(ISTANBUL MEDENIYET UNIVERSITY)0000-0002-1347-5019
Sayfa
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Yayın Tarihi
2024-09-02
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Conclusion: As a result, MPV measurement is a cost-effective and rapid method that can support the evaluation of disease severity and attack periods in FMF patients.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Objective: Familial Mediterranean Fever (FMF) is an autosomal recessive disease characterized by recurrent fever and polyserositis.
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Temel Bulgular & Veri:Method: 150 FMF patients (90 girls, 60 boys) and 50 healthy individuals (29 men, 21 women) were included in the study.
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Sonuç & Katkı:Conclusion: As a result, MPV measurement is a cost-effective and rapid method that can support the evaluation of disease severity and attack periods in FMF patients.
🔬Tür:Research Article
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Familial Mediterranean Fever · MPV · Neutrophil/Lymphocyte Ratio

Abstract

Objective: Familial Mediterranean Fever (FMF) is an autosomal recessive disease characterized by recurrent fever and polyserositis. Studies conducted in recent years emphasize the importance of platelet parameters in chronic diseases. This study examined changes in attack and attack-free periods in children with FMF, focusing on Mean Platelet Volume (MPV), an indicator of disease severity. Method: 150 FMF patients (90 girls, 60 boys) and 50 healthy individuals (29 men, 21 women) were included in the study. Data were analyzed according to colchicine treatment, attack, and attack-free periods. The severity of the disease was classified as mild, moderate, and severe. Results: MPV levels of patients with FMF were higher than the healthy group. In particular, MPV levels decreased significantly during attacks, with a more pronounced decrease in severe cases. Conclusion: As a result, MPV measurement is a cost-effective and rapid method that can support the evaluation of disease severity and attack periods in FMF patients.

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Bu Makaleye Atıf Yap

Trabzon, G., Ergüven, M., İşançlı, D. K., Yasa, E. O. (2024). Clinical significance of mean platelet volume, platelet distribution width, and neutrophil-lymphocyte ratio in children with familial mediterranean fever. Interdisciplinary Medical Journal, Volume: 15 Issue: 52. https://doi.org/10.17944/interdiscip.1432324

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