KaydedilenlerDerginizi ekleyin

Dergiler / Interdisciplinary Medical Journal / 2026 / Volume: 16 Issue: 54

Metformin-Associated Lactic Acidosis and Acute Kidney Injury

Can Hüzmeli(Hatay egitim ve araştırma hastanesi)0000-0002-5499-4886
Sayfa
—
Yayın Tarihi
2025-04-12
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

MALA diagnosis was based on metformin levels > 5 mg/L, decreased pH, low bicarbonate levels, lactate levels > 5 mmol/L, and increased anion gap.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:Diabetes mellitus is a common disease worldwide.
📊
Temel Bulgular & Veri:Metformin is included in the first-line treatment of type 2 diabetes mellitus.
💡
Sonuç & Katkı:MALA diagnosis was based on metformin levels > 5 mg/L, decreased pH, low bicarbonate levels, lactate levels > 5 mmol/L, and increased anion gap.
🔬Tür:Case Report
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Diabetes mellitus · metformin · lactic acidosis

Abstract

Diabetes mellitus is a common disease worldwide. Metformin is included in the first-line treatment of type 2 diabetes mellitus. Metformin-associated lactic acidosis (MALA) is rare but can be life-threatening. In this case report, MALA and acute kidney injury (AKI) were detected in a 74-year-old female patient who presented with impaired consciousness. The patient was treated with hydration and hemodialysis (HD). MALA diagnosis was based on metformin levels > 5 mg/L, decreased pH, low bicarbonate levels, lactate levels > 5 mmol/L, and increased anion gap.

🔖

Bu Makaleye Atıf Yap

Hüzmeli, C. (2025). Metformin-Associated Lactic Acidosis and Acute Kidney Injury. Interdisciplinary Medical Journal, Volume: 16 Issue: 54. https://doi.org/10.17944/interdiscip.1569484

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (19)

  1. Perveen W, Ahsan H, Shahzad R, Fayyaz S, Zaif A, Paracha MA, Alghadir AH. Prevalence of peripheral neuropathy, amputation, and quality of life in patients with diabetes mellitus. Scientific Reports, 2024;14(1):14430. https://doi.org/10.1038/s41598-024-65495-2
  2. Song A, Zhang C, Meng X. Mechanism and application of metformin in kidney diseases: An update. Biomedicine & Pharmacotherapy, 2021;138:111454. https://doi.org/10.1016/j.biopha.2021.111454.
  3. Aldobeaban S, Mzahim B and Alshehri AA. Recurrent hypoglycemia secondary to metformin toxicity in the absence of co-ingestions: a case repor, JMCR 2018; 12:223. https://doi.org/10.1186/s13256-018-1758-0
  4. CorcoranC. Metformin.; Tibb F. Jacobs. StatPearls Publishing; 2024
  5. Dyatlova N, Tobarran NV, Kannan L, North R, Wills BK. Metformin associated lactic acidosis (MALA). 2022.
  6. Simon EL, Sherry AC, Rabinowitz J. Metformin-Associated Lactic Acidosis-Is This on Your Radar?. JEM, 2024;66(4): e530-e533. https://doi.org/10.1016/j.jemermed.2023.11.017
  7. DeFronzo R, Fleming GA, Chen K, Bicsak TA. Metformin-associated lactic acidosis: Current perspectives on causes and risk. Metabol, 2016;65(2): 20-29. https://doi.org/10.1016/j.metabol.2015.10.014.
  8. Di Mauro S, Filippello A, Scamporrino A, Purrello F, Piro S, Malaguarnera R. Metformin: when should we fear lactic acidosis?. Int. J. Mol. Sci, 2022;23(15):8320. https://doi.org/10.3390/jms23158320
  9. See KC. Metformin-associated lactic acidosis: A mini review of pathophysiology, diagnosis and management in critically ill patients. WJD, 2024;15(6):1178. https://doi.org/10.4239/wjd.v15.i6.1178
  10. Corchia A, Wynckel A, Journet J, Moussi Frances J, Skandrani N, Lautrette A, Rieu P. Metformin-related lactic acidosis with acute kidney injury: results of a French observational multicenter study. Clinical Toxicology, 2020;58(5): 375-382. https://doi.org/10.1080/15563650.2019.1648816
  11. Kim S, Sarwal A, Yee XT, Fraga SAG, Campion V, Gnanasekaran I. Metformin-associated lactic acidosis (MALA): Is it an underestimated entity? A retrospective, single-center case series. Hemodialysis International, 2024;28(1):32-39. https://doi.org/10.1111/hdi.13113
  12. Goonoo MS, Morris R, Raithatha A, Creagh F. Metformin-associated lactic acidosis: reinforcing learning points. DTB, BMJ, 2020;13(9): e235608. https://doi.org/10.1136/dtb.2021.235608rep
  13. Vordoni A, Theofilis P, Vlachopanos G, Koukoulaki M, Kalaitzidis RG. Metformin-associated lactic acidosis and acute kidney injury in the era of COVID-19. Frontiers in Bioscience-Scholar, 2021;13(2):202-207. https://doi.org/10.52586/S563
  14. Ariga M, Hagita J, Soda M, Oida Y, Teramachi H, Kitaichi K. Daily dose of metformin caused acute kidney injury with lactic acidosis: a case report. JMCR, 2023;17(1): 393. https://doi.org/10.1186/s13256-023-04136-0
  15. Alotaibi M, Ali F, Leung S, Kent R. Metformin Induced Lactic Acidosis What Is the Effective Treatment?. OJNeph, 2020;10(1): 11-17. https://doi.org/10.4236/ojneph.2020.101002
  16. Wills BK, Bryant SM, Buckley P, Seo B. Can acute overdose of metformin lead to lactic acidosis? Am J Emerg Med. 2010;28(8):857-861. https://doi.org/10.1016/j.ajem.2009.04.012
  17. Calello DP, Liu KD, Wiegand TJ, Roberts DM, Lavergne V, Gosselin S, Hoffman RS, Nolin TD, Ghannoum M., Extracorporeal Treatments in Poisoning Workgroup. Extracorporeal Treatment for Metformin Poisoning: Systematic Review and Recommendations From the Extracorporeal Treatments in Poisoning Workgroup. Crit Care Med. 2015;43(8):1716-1730. https://doi.org/10.1097/ccm.0000000000001002
  18. Eppenga WL, Lalmohamed A, Geerts AF, Derijks HJ, Wensing M, Egberts A, et al. Risk of lactic acidosis or elevated lactate concentrations in metformin users with renal impairment: a population-based cohort study. Diabetes Care. 2014;37(8):2218–2224. https://doi.org/10.2337/dc13-3023
  19. CorcoranC. Metformin.; Tibb F. Jacobs. StatPearls Publishing; 2024