Dergiler / Interdisciplinary Medical Journal / 2026 / Volume: 17 Issue: 58

Asthma evaluation of risk factors in atopic patients in the Hatay Region

Kadir Burak Akgün(HATAY MUSTAFA KEMAL ÜNİVERSİTESİ, TAYFUR ATA SÖKMEN TIP FAKÜLTESİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, GÖĞÜS HASTALIKLARI ANABİLİM DALI)0000-0002-3017-1025
Sahinur Aycan Alkan(HATAY MUSTAFA KEMAL ÜNİVERSİTESİ, TAYFUR ATA SÖKMEN TIP FAKÜLTESİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, GÖĞÜS HASTALIKLARI ANABİLİM DALI)0000-0001-8233-2639
Ömer Atar(HATAY MUSTAFA KEMAL ÜNİVERSİTESİ, TAYFUR ATA SÖKMEN TIP FAKÜLTESİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, GÖĞÜS HASTALIKLARI ANABİLİM DALI)0009-0000-2830-9489
Sayfa
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Yayın Tarihi
2026-08-23
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Tree pollen and cockroach sensitizations, rather than house dust mites, were proven as the strongest independent determinants of asthma development among the studied population in the Mediterranean climate of Hatay, influenced by climate change and precipitation.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Objective: This study investigated the role of systemic inflammatory indices and specific aeroallergen sensitizations in predicting asthma among patients with allergic rhinitis (AR) and asthma, within the United Airway Disease (UAD) framework.
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Temel Bulgular & Veri:Method: A retrospective study was conducted including 575 patients who underwent skin prick testing (SPT).
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Sonuç & Katkı:Tree pollen and cockroach sensitizations, rather than house dust mites, were proven as the strongest independent determinants of asthma development among the studied population in the Mediterranean climate of Hatay, influenced by climate change and precipitation.
🔬Tür:Modelleme & Sayısal Simülasyon
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:aeroallergens · allergic rhinitis · asthma

Abstract

Objective: This study investigated the role of systemic inflammatory indices and specific aeroallergen sensitizations in predicting asthma among patients with allergic rhinitis (AR) and asthma, within the United Airway Disease (UAD) framework. Method: A retrospective study was conducted including 575 patients who underwent skin prick testing (SPT). Patients were categorized into four groups: healthy controls, AR only, allergic asthma, and non-allergic asthma. Demographics, SPT results, and inflammatory indices were compared. Independent risk factors for asthma were analyzed via multivariate logistic regression. Results: No statistically significant differences in eosinophil levels or systemic inflammatory indices were detected among the four phenotypes (p>0.05). However, the median age and the proportion of females were observed to be higher in asthmatic patients. In the multivariate analysis, increasing age (OR: 1.019), being female sex (OR: 1.515), tree pollen (OR: 1.953), and cockroach (OR: 1.618) sensitizations were identified as independent risk factors for asthma. House dust mite sensitization was lost its significance in the multivariate model. Conclusion: The predictive value of systemic inflammatory indices in distinguishing asthma phenotypes is considered low in stable atopic patients. Tree pollen and cockroach sensitizations, rather than house dust mites, were proven as the strongest independent determinants of asthma development among the studied population in the Mediterranean climate of Hatay, influenced by climate change and precipitation.

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Bu Makaleye Atıf Yap

Akgün, K. B., Alkan, S. A., Atar, Ö. (2026). Asthma evaluation of risk factors in atopic patients in the Hatay Region. Interdisciplinary Medical Journal, Volume: 17 Issue: 58. https://doi.org/10.17944/interdiscip.1900993

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Kaynakça (35)

  1. Global Initiative for Asthma. 2025 GINA Strategy Report [Internet]. 2025 [cited 2026 Mar 2]. Available from: https://ginasthma.org/2025-gina-strategy-report/
  2. Bousquet J, Schünemann HJ, Togias A, Bachert C, Erhola M, Hellings PW, et al. Next-generation Allergic Rhinitis and Its Impact on Asthma (ARIA) guidelines for allergic rhinitis based on Grading of Recommendations Assessment, Development and Evaluation (GRADE) and real-world evidence. J Allergy Clin Immunol. 2020;145(1):70-80.e3. https://doi.org/10.1016/j.jaci.2019.06.049.
  3. Licari A, Castagnoli R, Denicolò CF, Rossini L, Marseglia A, Marseglia GL. The nose and the lung: united airway disease?Front Pediatr. 2017;5. https://doi.org/10.3389/fped.2017.00044.
  4. Bondi B, Buscema M, Di Marco F, Conti C, Caviglia A, Fucci L, et al. Connecting the airways: current trends in united airway diseases. J Pers Med. 2026;16(1):21. https://doi.org/10.3390/jpm16010021.
  5. Bachert C, Luong AU, Gevaert P, Mullol J, Smith SG, Silver J, et al. The unified airway hypothesis: evidence from specific intervention with anti–IL-5 biologic therapy. J Allergy Clin Immunol Pract. 2023;11(9):2630–41. https://doi.org/10.1016/j.jaip.2023.05.011.
  6. Xie ZJ, Guan K, Yin J. Advances in the clinical and mechanism research of pollen induced seasonal allergic asthma.Am J Clin Exp Immunol. 2019;8(1):1–8.
  7. Nur Husna SM, Tan HT, Md Shukri N, Mohd Ashari NS, Wong KK. Allergic rhinitis: a clinical and pathophysiological overview.Front Med. 2022;9:874114. https://doi.org/10.3389/fmed.2022.874114.
  8. Kim CK, Callaway Z, Park JS, Pawankar R, Fujisawa T. Biomarkers in allergen immunotherapy: focus on eosinophilic inflammation.Asia Pac Allergy. 2024;14(1):32–8. https://doi.org/10.5415/apallergy.0000000000000129.
  9. Nagase H, Suzukawa M, Oishi K, Matsunaga K. Biologics for severe asthma: the real-world evidence, effectiveness of switching, and prediction factors for the efficacy.Allergol Int. 2023;72(1):11–23. https://doi.org/10.1016/j.alit.2022.11.008.
  10. Solomon Y, Malkamu B, Berhan A, Eyayu T, Almaw A, Legese B, et al. Peripheral blood eosinophilia in adult asthmatic patients and its association with the severity of asthma.BMC Pulm Med. 2023;23(1):96. https://doi.org/10.1186/s12890-023-02383-x.
  11. Chipps BE, Jarjour N, Calhoun WJ, Iqbal A, Haselkorn T, Yang M, et al. A comprehensive analysis of the stability of blood eosinophil levels.Ann Am Thorac Soc. 2021;18(12):1978–87. https://doi.org/10.1513/AnnalsATS.202010-1249OC.
  12. Torabizadeh M, Aghaei M, Saki N, Vahid MA, Bitaraf S, Bandar B. The association of nasal and blood eosinophils with serum IgE level in allergic rhinitis and asthma: a case-control study.Health Sci Rep. 2024;7(11):e70191. https://doi.org/10.1002/hsr2.70191.
  13. Chowdhury NU, Guntur VP, Newcomb DC, Wechsler ME. Sex and gender in asthma.Eur Respir Rev. 2021;30(162):210067. https://doi.org/10.1183/16000617.0067-2021.
  14. Kole TM, Muiser S, Kraft M, Siddiqui S, Fabbri LM, Rabe KF, et al. Sex differences in asthma control, lung function and exacerbations: the ATLANTIS study.BMJ Open Respir Res. 2024;11(1):e002316. https://doi.org/10.1136/bmjresp-2024-002316.
  15. Peng B, Ye W, Liu S, Jiang Y, Meng Z, Guo M, et al. Sex differences in asthma: omics evidence and future directions.Front Genet. 2025;16:1560276. https://doi.org/10.3389/fgene.2025.1560276.
  16. Katelaris CH, Beggs PJ. Climate change: allergens and allergic diseases.Intern Med J. 2018;48(2):129–34. https://doi.org/10.1111/imj.13699.
  17. Topuz M, Karabulut M, Korkmaz H. Trend analysis of precipitation in Hatay.J Int Soc Res. 2016;9(43):1186–94.
  18. Aydin İ, Demir A, Güdül H. Kızılağaç (alnus glutinosa subsp. barbata (C.A. Mey.) Yalt.) kontrplaklarının bazı teknolojik özellikleri üzerine dikim aralığının etkisi.Politek Derg. 2019;22(3):771–7. https://doi.org/10.2339/politeknik.446880.
  19. Dobrowolska D, Hein S, Oosterbaan A, Wagner S, Clark J, Skovsgaard JP. A review of European ash (Fraxinus excelsior L.): implications for silviculture. Forestry. 2011;84(2):133–48. https://doi.org/10.1093/forestry/cpr001.
  20. Özdemir Ö, Bingöl Aydın D. Cockroach allergy and its immunotherapy. Asthma Allergy Immunol. 2016;14(1):1–10. https://doi.org/10.21911/aai.4034.
  21. Chew GL. Assessment of environmental cockroach allergen exposure. Curr Allergy Asthma Rep. 2012;12(5):456–64. https://doi.org/10.1007/s11882-012-0287-y.
  22. Erdoğan A, Koçak Ö. Hamamböceği, Blatella Germanica (L), popülasyonlarında NİMF süresi ve ergin ömür uzunlugu ile ilgili araştırmalar. HacettepeUniv Egit Fak Derg. 1989;(4):235–8.
  23. Şimşek O, Gümüş V, Soydan N, Yenigün K, Kavşut M, Topçu M. Hatay ilinde bazı meteorolojik verilerin didiş analizi. Uluslararası Teknolojik Bilimler Dergisi. 2013;5(2):132–44.
  24. Abu Khweek A, Kim E, Joldrichsen MR, Amer AO, Boyaka PN. Insights into mucosal innate immune responses in house dust mite-mediated allergic asthma.Front Immunol. 2020;11:534501. https://doi.org/10.3389/fimmu.2020.534501.
  25. Wu CH, Lee MF. Molecular characteristics of cockroach allergens.Cell Mol Immunol. 2005;2(3):177–80.
  26. Kılıç M, Taşkın E. Alerjik astımlı çocukların klinik özelliklerinin ve risk faktörlerinin değerlendirilmesi. Firat Med J 2015;20(4):199-205
  27. Kurtuluş Ş, Can R, Sak ZH. Atopik astımlı Türkiye Cumhuriyeti vatandaşları ile mültecilerin deri prick test sonuçlarının karşılaştırılması. Harran Üniv Tıp Fak Derg 2020;17(2):228-32.
  28. Xia S, Zhu Z, Guan W, Xie Y, An J, Peng T, et al. Correlation between upper and lower airway inflammations in patients with combined allergic rhinitis and asthma syndrome: a comparison of patients initially presenting with allergic rhinitis and those initially presenting with asthma.Exp Ther Med. 2018;15(2):1761-7. https://doi.org/10.3892/etm.2017.5536.
  29. Ozen Olcay H, Emektar E, Atayik E, Cevik Y. Evaluation of the relationship between systemic inflammatory markers and biphasic reaction in patients diagnosed with anaphylaxis. Asthma Allergy Immunol. 2025;23:172–9. https://doi.org/10.21911/aai.2025.852.
  30. Shi G, Zhao JW, Ming L. [Clinical significance of peripheral blood neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in patients with asthma]. Nan Fang Yi Ke Da Xue Xue Bao. 2017;37(1):84–8. https://doi.org/10.3969/j.issn.1673-4254.2017.01.15.
  31. Yalim SA, Kalpaklıoglu AF, Baccıoglu A, Poyraz M, Alpagat G, Dumanoglu B. Evaluation of systemic inflammation markers in patients with rhinitis. Allergo J Int. 2023;33:24–31. https://doi.org/10.1007/s40629-023-00277-2.
  32. Fan Y, Wen Y, Yang Y, Li W, Deng Z, Huang Q. The relationship of systemic inflammatory index with asthma in adults: a retrospective cross-sectional study.J Int Med Res. 2025;53(11):03000605251396314. https://doi.org/10.1177/03000605251396314.
  33. Licari A, Castagnoli R, Denicolò CF, Rossini L, Marseglia A, Marseglia GL. The nose and the lung: united airway disease?Front Pediatr. 2017;5. https://doi.org/10.3389/fped.2017.00044.
  34. Xie ZJ, Guan K, Yin J. Advances in the clinical and mechanism research of pollen induced seasonal allergic asthma.Am J Clin Exp Immunol. 2019;8(1):1–8.
  35. Nur Husna SM, Tan HT, Md Shukri N, Mohd Ashari NS, Wong KK. Allergic rhinitis: a clinical and pathophysiological overview.Front Med. 2022;9:874114. https://doi.org/10.3389/fmed.2022.874114.