Dergiler / ACH Medical journal / 2026 / Volume: 3 Issue: 1

An early prognostic marker for determining disease severity in acute cholangitis: CRP/albumin ratio

Sema Nur Arasan(Oltu Devlet Hastanesi Erzurum)0000-0001-5264-325X
Osman İnan(Ankara Bilkent Şehir Hastanesi)0000-0002-8717-3013
Enes Seyda Şahiner(Ankara Bilkent Şehir Hastanesi)0000-0003-4552-0387
Aziz Surel(Ankara Bilkent Şehir Hastanesi)0000-0002-4992-1754
Emin Altıparmak(Ankara Bilkent Şehir Hastanesi)0000-0001-8900-9498
Oğuzhan Zengin(Ankara Bilkent Şehir Hastanesi)0000-0001-6575-4450
İhsan Ateş(Ankara Bilkent Şehir Hastanesi)0000-0003-2858-6229
Sayfa
—
Yayın Tarihi
2024-03-29
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Conclusion: We found that the CAR is a good prognostic marker in determining the severity of acute cholangitis in the early period.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:Introductıon: This study was undertaken to investigate the importance of the CRP/albumin ratio (CAR) as an early prognostic marker for determining disease severity in acute cholangitis.
📊
Temel Bulgular & Veri:Methods: A total of 366 patients aged >18 years diagnosed with acute cholangitis were included in the study.
💡
Sonuç & Katkı:Conclusion: We found that the CAR is a good prognostic marker in determining the severity of acute cholangitis in the early period.
🔬Tür:Research Article
📍Kapsam:2018 Verileri
⚙️Değişkenler:Choledocholithiasis · Cholestasis · Cholangitis

Abstract

Introductıon: This study was undertaken to investigate the importance of the CRP/albumin ratio (CAR) as an early prognostic marker for determining disease severity in acute cholangitis. Methods: A total of 366 patients aged >18 years diagnosed with acute cholangitis were included in the study. Acute cholangitis severity was determined according to the 2018 Tokyo criteria. Results: The study population consisted of 49.2% patients with mild, 24.6% moderate, and 26.2% severe acute cholangitis. The cut-off CAR value for predicting moderate risk compared to the mild risk group was found to be >1 with 73.3% sensitivity and 76.7% specificity (AUC±SE: 0.785±0.03; +PV: 61.1%, -PV: 85.2%; p 2.9 with 71.9% sensitivity and 71.1% specificity (AUC±SE: 0.788±0.03; +PV: 72.6%, -PV: 70.3%; p 2.5 with 77.4% sensitivity and 74.6% specificity (AUC±SE: 0.803±0.03; +PV: 43.1%, -PV: 90.1%; p 2.8 with 100% sensitivity and 74.9% specificity (AUC±SE: 0.890±0.03; +PV: 19.5%, -PV: 100%; p<0.001). Compared to its components, the CAR was found to exhibit superior diagnostic performance in predicting moderate or severe risk, ICU admission, and mortality. Conclusion: We found that the CAR is a good prognostic marker in determining the severity of acute cholangitis in the early period.

🔖

Bu Makaleye Atıf Yap

Arasan, S. N., İnan, O., Şahiner, E. S., Surel, A., Altıparmak, E., Zengin, O., Ateş, İ. (2024). An early prognostic marker for determining disease severity in acute cholangitis: CRP/albumin ratio. ACH Medical journal, Volume: 3 Issue: 1. https://ajindex.com/articles/1628850

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (21)

  1. Sulzer, J.K. & Ocuin, L.M. Cholangitis: causes, diagnosis, and management. Surgical Clinics 99, 175-184 (2019).
  2. Endo, I., Takada, T., Hwang, T.L., Akazawa, K., Mori, R., Miura, F. et al. Optimal treatment strategy for acute cholecystitis based on predictive factors: Japan‐Taiwan multicenter cohort study. Journal of Hepato‐Biliary‐Pancreatic Sciences 24, 346-361 (2017).
  3. Miura, F., Takada, T., Strasberg, S.M., Solomkin, J.S., Pitt, H.A., Gouma, D.J. et al. TG13 flowchart for the management of acute cholangitis and cholecystitis. Journal of hepato-biliary-pancreatic sciences 20, 47-54 (2013).
  4. Kiriyama, S., Kozaka, K., Takada, T., Strasberg, S.M., Pitt, H.A., Gabata, T. et al. Tokyo Guidelines 2018: diagnostic criteria and severity grading of acute cholangitis (with videos). Journal of Hepato‐Biliary‐Pancreatic Sciences 25, 17-30 (2018).
  5. Kaplan M, Duzenli T, Tanoglu A, Cakir Guney B, Onal Tastan Y, Bicer HS. Presepsin:albumin ratio and C-reactive protein:albumin ratio as novel sepsis-based prognostic scores: A retrospective study. Wien Klin Wochenschr. 2020 Apr;132(7-8):182-187. doi: 10.1007/s00508-020-01618-9. Epub 2020 Feb 14. PMID: 32060723.
  6. Kaplan, M., Ates, I., Akpinar, M.Y., Yuksel, M., Kuzu, U.B., Kacar, S. et al. Predictive value of C-reactive protein/albumin ratio in acute pancreatitis. Hepatobiliary & Pancreatic Diseases International 16, 424-430 (2017).
  7. Kinoshita, A., Onoda, H., Imai, N., Iwaku, A., Oishi, M., Tanaka, K. et al. The C-reactive protein/albumin ratio, a novel inflammation-based prognostic score, predicts outcomes in patients with hepatocellular carcinoma. Annals of surgical oncology 22, 803-810 (2015).
  8. Kiyak M, Tanoglu A. Comparison of the Efficacy of Balthazar Score and C-Reactive Protein-Albumin Ratio for Determination of Acute Pancreatitis Severity. Curr Health Sci J. 2022 Jan-Mar;48(1):81-87. doi: 10.12865/CHSJ.48.01.12. Epub 2022 Mar 31. PMID: 35911938; PMCID: PMC9289588.
  9. Qin, G., Tu, J., Liu, L., Luo, L., Wu, J., Tao, L. et al. Serum albumin and C-reactive protein/albumin ratio are useful biomarkers of Crohn’s disease activity. Medical science monitor 22, 4393-4400 (2016).
  10. Kiriyama, S., Takada, T., Strasberg, S.M., Solomkin, J.S., Mayumi, T., Pitt, H.A. et al. TG13 guidelines for diagnosis and severity grading of acute cholangitis (with videos). Journal of hepato-biliary-pancreatic sciences 20, 24-34 (2013).
  11. Sayar, S., Kurbuz, K., Kahraman, R., Caliskan, Z., Atalay, R., Ozturk, O. et al. A practical marker to determining acute severe ulcerative colitis: CRP/albumin ratio. Northern clinics of Istanbul 7, 49 (2020).
  12. Liu, Z., Shi, H. & Chen, L. Prognostic role of pre-treatment C-reactive protein/albumin ratio in esophageal cancer: a meta-analysis. BMC cancer 19, 1-9 (2019).
  13. Mocellin, M.C., Pastore e Silva, J.d.A., Camargo, C.d.Q., Fabre, M.E.d.S., Gevaerd, S., Naliwaiko, K. et al. Fish oil decreases C-reactive protein/albumin ratio improving nutritional prognosis and plasma fatty acid profile in colorectal cancer patients. Lipids 48, 879-888 (2013).
  14. Mao, M., Wei, X., Sheng, H., Chi, P., Liu, Y., Huang, X. et al. C‑reactive protein/albumin and neutrophil/lymphocyte ratios and their combination predict overall survival in patients with gastric cancer. Oncology letters 14, 7417-7424 (2017).
  15. Yasukawa, K., Shimizu, A., Motoyama, H., Kubota, K., Notake, T., Fukushima, K. et al. Preoperative C‐reactive protein‐to‐albumin ratio predicts long‐term outcomes in extrahepatic cholangiocarcinoma patients. Journal of surgical oncology 122, 1094-1105 (2020).
  16. Hamano, K., Noguchi, O., Matsumoto, Y., Watabe, T., Numata, M., Yosioka, A. et al. Usefulness of procalcitonin for severity assessment in patients with acute cholangitis. Clinical laboratory 59, 177-183 (2013).
  17. Shinya, S., Sasaki, T., Yamashita, Y., Kato, D., Yamashita, K., Nakashima, R. et al. Procalcitonin as a useful biomarker for determining the need to perform emergency biliary drainage in cases of acute cholangitis. Journal of Hepato‐Biliary‐Pancreatic Sciences 21, 777-785 (2014).
  18. Umefune, G., Kogure, H., Hamada, T., Isayama, H., Ishigaki, K., Takagi, K. et al. Procalcitonin is a useful biomarker to predict severe acute cholangitis: a single-center prospective study. Journal of Gastroenterology 52, 734-745 (2017).
  19. Lyu, Y., HE, J., Wang, B., XU, Y., DU, W. & Cheng, Y. The role of procalcitonin in patients with different severity grades of acute cholangitis. Chinese Journal of Hepatobiliary Surgery, 428-430 (2014).
  20. Lin, J., Sun, H., Li, J., Zheng, Y., Shao, C., Zhang, Y.H. et al. Role of Presepsin for the Assessment of Acute Cholangitis Severity. Clinical Laboratory 62, 679-687 (2016).
  21. Kaplan M, Duzenli T, Tanoglu A, Cakir Guney B, Onal Tastan Y, Bicer HS. Presepsin:albumin ratio and C-reactive protein:albumin ratio as novel sepsis-based prognostic scores: A retrospective study. Wien Klin Wochenschr. 2020 Apr;132(7-8):182-187. doi: 10.1007/s00508-020-01618-9. Epub 2020 Feb 14. PMID: 32060723.