The physician must be careful and keep in mind be developed of this clinical condition in patient under heparin treatment.
📌 3 Maddede Bu Makale
🎯
Amaç & Hipotez:Heparin-induced thrombocytopenia is a rare and life-threatening condition of exposure to heparin.
📊
Temel Bulgular & Veri:Pulmonary emboli and progressively decreased number of thrombocytes developed during the low molecular weight heparin treatment.
💡
Sonuç & Katkı:The physician must be careful and keep in mind be developed of this clinical condition in patient under heparin treatment.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri
Özet
Heparin-induced thrombocytopenia is a rare and life-threatening condition of exposure to heparin. A case of heparin-induced thrombocytopenia due to the low molecular weight heparin was presented. Pulmonary emboli and progressively decreased number of thrombocytes developed during the low molecular weight heparin treatment. For that reason, the heparin-induced thrombocytopenia was diagnosed. The heparin was ceased and fondaparinux treatment initiated. Platelet levels returned to normal limits within six days. The delaying in diagnosis of heparin-induced thrombocytopenia causes serious outcomes. The physician must be careful and keep in mind be developed of this clinical condition in patient under heparin treatment.
🔖
Bu Makaleye Atıf Yap
DURMUŞ, Y., KARYAL, Y. A., KILIÇ, Ç., ÇAKIR, C., YÜKSEL, D., SEYHAN, B., BOYRAZ, G., COMERT, G. K., TURAN, T. (2019). An Ovarian Cancer Patient Presenting Heparin-Induced Thrombocytopenia After Use of Low Molecular Weight Heparin: A Case Report of Rare Condition. GORM:Gynecology Obstetrics & Reproductive Medicine, Cilt: 25 - Sayı: 3, 176–179. https://ajindex.com/articles/161822
Linkins LA, Dans AL, Moores LK, Bona R, Davidson BL, Schulman S. et al. Treatment and prevention of heparininduced thrombocytopenia: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012;141(2, Suppl): e495S-e530S
Keeling D, Davidson S, Watson H. The management of heparin-induced thrombocytopenia. Br J Haematol. 2006; 133(3):259-69
Salter BS, Weiner MM, Trinh MA, Heller J, Evans AS, Adams DH. et al. Heparin-induced thrombocytopenia: a comprehensive clinical review. J Am Coll Cardiol. 2016;67(21):2519-32
Greinacher A, Völpel H, Janssens U, Hach-Wunderle V, Kemkes-Matthes B, Eichler P, et al. Recombinant hirudin (Lepirudin) provides safe and effective anticoagulation in patients with heparin induced thrombocytopenia. Circulation. 1999;99(1):73-80
LaMonte M P, Brown P M, Hursting M J. Stroke in patients with heparin-induced thrombocytopenia and the effect of argatroban therapy. Crit Care Med. 2004;32(4): 976-80
Warkentin TE, Greinacher A, Koster A, Lincoff AM. Treatment and prevention of heparin-induced thrombocytopenia: American College of Chest Physicians EvidenceBased Clinical Practice Guidelines (8th Edition). 2008;133(6 Suppl):340S
Warkentin TE. Thromb Haemost. Clinical picture of heparin-induced thrombocytopenia (HIT) and its differentiation from non-HIT thrombocytopenia. Thromb Haemost. 2016;116(5):813-22
Favaloro EJ, McCaughan G, Pasalic L. Clinical and laboratory diagnosis of heparin induced thrombocytopenia: an update. Pathology. 2017;49(4):346-55
Martel N, Lee J, Wells PS. Risk for heparin-induced thrombocytopenia with unfractionated and low-molecular-weight heparin thromboprophylaxis: a meta-analysis. Blood. 2005;106(8):2710-5
Smythe MA, Koerber JM, Mattson JC. The incidence of recognized heparin-induced thrombocytopenia in a large, tertiary care teaching hospital. 2007;131(6):1644-9. 11. www.hematology.org/Clinicians/Guidelines-Quality/ Guidelines.aspx. (2018)
Lo GK, Juhl D, Warkentin TE, Sigouin CS, Eichler P, Greinacher A. Evaluation of pretest clinical score (4 T's) for the diagnosis of heparin-induced thrombocytopenia in two clinical settings. J Thromb Haemost. 2006; 4(4):759-6
Sagaram D, Siddiq Z, Eisenberger AB, Ananth CV, Wright JD, D'Alton ME, et al. Heparin-Induced thrombocytopenia during obstetric hospital admissions. Am J Perinatol. 2018;35(9):898-903