Further Considerations on the Prognostic Significance of Lin28A Expression in Vulvar Squamous Cell Carcinoma

Abstract

We read with interest the recent study by Yaldır et al. evaluating Lin28A expression in vulvar squamous cell carcinoma (VSCC). The authors reported Lin28A positivity in approximately 42% of tumors and suggested its potential prognostic and therapeutic relevance. While these findings provide valuable preliminary data in an understudied field, several aspects merit further discussion. Lin28A positivity was observed more frequently in early-stage than advanced-stage tumors, raising questions regarding its biological role in disease progression. In addition, the availability of long-term follow-up data highlights the potential value of survival analyses for clarifying prognostic significance. We also emphasize the importance of evaluating Lin28A expression within HPV-associated and HPV-independent molecular subgroups of VSCC. Further multicenter studies integrating molecular profiling and survival-based analyses are warranted to better define the clinical significance of Lin28A in vulvar squamous cell carcinoma.