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Dergiler / GORM:Gynecology Obstetrics & Reproductive Medicine / 2019 / Cilt: 25 - Sayı: 2

The Effect Follicular Fluid Vitamin A, E, D and B6 on Embryo Morphokinetics and Pregnancy Rates in Patients Receiving Assisted Reproduction

FUNDA GÖDE
Süleyman AKARSU
Zeliha GUNNUR DIKMEN
Burcu TAMER
Ahmet Zeki IŞIK
Sayfa
89–95
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

However, none of the vitamins considered showed a significant relationship with clinical pregnancy rates.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:OBJECTIVE: To evaluate the associations among levels of vitamins A, E, D, and B6 in follicular fluid embryo morphokinetics and quality, and clinical pregnancy rates.
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Temel Bulgular & Veri:STUDY DESIGN: A total of 58 patients with unexplained infertility admitted to the in vitro fertilisation cen- ter of Izmir Medical Park Hospital were included in this prospective clinical study.
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Sonuç & Katkı:However, none of the vitamins considered showed a significant relationship with clinical pregnancy rates.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

OBJECTIVE: To evaluate the associations among levels of vitamins A, E, D, and B6 in follicular fluid embryo morphokinetics and quality, and clinical pregnancy rates. STUDY DESIGN: A total of 58 patients with unexplained infertility admitted to the in vitro fertilisation cen- ter of Izmir Medical Park Hospital were included in this prospective clinical study. For each patient, vita- min levels were assayed using high-performance liquid chromatography. After intracytoplasmic sperm injection, for each oocyte, the relationships between each vitamin and subsequent embryo quality, em- bryo morphokinetics, and clinical pregnancy rates were investigated. Embryos were classified as grade A, B, C, or D according to morphokinetic parameters using t5 - t2 and t5 - t3 (cc3). RESULTS: There was no significant correlation between embryo morphokinetic parameters (tpnf, t2, t3, t4, t5, t6, t7 and t8) and follicular fluid vitamin (A, B6, D, and E) levels (p >0.05). There was a significant positive correlation between t5 optimal and follicular fluid vitamin A levels (p <0.05). There was a significant positive correlation between cc2 optimal and follicular fluid vitamin B6 levels (p <0.05). Levels of vitamins A and B6 were significantly higher in grade A and B embryos than in grade C and D embryos. There were no significant relationships between vitamins E or D and embryo quality or between any vitamin and clinical pregnancy rates. CONCLUSION: High levels of vitamins A and B6 in follicular fluid are significantly associated with high- quality embryos and optimal morphokinetics. However, none of the vitamins considered showed a significant relationship with clinical pregnancy rates.

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Bu Makaleye Atıf Yap

GÖDE, F., AKARSU, S., DIKMEN, Z. G., TAMER, B., IŞIK, A. Z. (2019). The Effect Follicular Fluid Vitamin A, E, D and B6 on Embryo Morphokinetics and Pregnancy Rates in Patients Receiving Assisted Reproduction. GORM:Gynecology Obstetrics & Reproductive Medicine, Cilt: 25 - Sayı: 2, 89–95. https://ajindex.com/articles/161112

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Kaynakça (12)

  1. Revelli A, Piane LD, Casano S, Molinari E, Massobrio M, Rinaudo P. Follicular fluid content and oocyte quality: from single biochemical markers to metabolomics. Reprod Biol Endocrinol. 2009;7:40. Castro L, Freeman BA. Reactive oxygen species in human health and disease. Nutrition. 2001;17(2):161-5.
  2. Seifried HE, Anderson DE, Fisher EI, Milner JA. A review of the interaction among dietary antioxidants and reactive oxygen species. J Nutr Biochem. 2007;18(9):567-79.
  3. Khazaei M, Aghaz F. Reactive oxygen species generation and use of antioxidants during in vitro maturation of oocytes. Int J Fertil Steril. 2017;11(2):63-70.
  4. Kowaltowski AJ, Vercesi A. Mitochondrial damage in- duced by conditions of oxidative stress. Free Radic Biol Med 1999;26(3):463-71.
  5. Nakamura Y, Yagamata Y, Sugino N, Takayama H, Kato H. Nitric oxide inhibits oocyte maturation. Biol Reprod. 2002;67(5):1588-92.
  6. Hashimoto S, Minami N, Yamada M, Imai H. Excessice concentration of glucose during in vitro maturation im- pairs the developmental competence of bovine oocytes after in vitro fertilization: relevance to intracellular reac- tive oxygen species and glutathione contents. Mol Reprod Dev. 2000;56(4):520-6.
  7. Pandey AN, Chaube SK. A moderate increase of hydrogen peroxide level is beneficial for spontaneous resumption of meiosis from diplotene arrest in rat oocytes cultured in vitro. Biores Open Acess. 2014;3(4):183-91.
  8. Agarwal A, Gupta S, Sharma RK. Role of oxidative stress in female reproduction. Reprod Biol Endocrinol. 2005; 3:28. Luddi A, Capaldo A, Focarelli R, Gori M, Morgante G, Piomboni P, et al. Antioxidants reduce oxidative stress in follicular fluid of aged women undergoing IVF. Reprod Biol Endocrinol. 2016;14(1):57. Ikeda S, Kitagawa M, Imai H, Yamada M. The roles of vi- tamin A for cytoplasmic maturation of bovine oocytes. J Reprod Dev. 2005;51(1):23-35.
  9. Sies H, Stahl W. Vitamin E and C, beta-carotene, and other carotenoids as antioxidants. Am J Clin Nutr. 1995;62 (6 Suppl):1315-21.
  10. Al-Azemi MK, Omu AE, Fatinikun T, Mannazhath N, Abraham S. Factors contributing to gender differences in serum retinol and alpha-tocopherol in infertile couples. Reprod Biomed Online. 2009;19(4):583-90.
  11. Bansal AK, Bilaspuri GS. Antioxidant effect of vitamin E on motility, viability and lipid peroxidation of cattle sper- matozoa under oxidative stress. Anim Sci Pap Rep. 2009;27(1):5-14.
  12. Tsuji H, Muranaka M, Hamano K. Culture of in vitro mouse embryos with vitamin E improves development. J Reprod Dev. 2002;48