Dergiler / Experimental Biomedical Research / 2020 / Cilt: 3 - Sayı: 4

Cholelithiasis and gastrointestinal cancer: Is there a relationship that increases the risk of developing cancer?

Sayfa
248–254
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

However, the role of asymptomatic and symptomatic stones, which may or may not require cholecystectomy, in the development of GI tract cancers should not be ignored.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Aim: To investigate the co-existence of cholelithiasis in patients with gastrointestinal (GI) cancer both in preoperative and postoperative periods.
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Temel Bulgular & Veri:Methods: We retrospectively analyzed the data of patients who underwent GI tract cancer surgery in the general surgery clinic of a university hospital between January 2013 and December 2019 for the presence of 'cholelithiasis' in the preoperative and postoperative periods.
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Sonuç & Katkı:However, the role of asymptomatic and symptomatic stones, which may or may not require cholecystectomy, in the development of GI tract cancers should not be ignored.
🔬Tür:Araştırma Makalesi
📍Kapsam:2013 Verileri
⚙️Değişkenler:Alan Parametreleri

Özet

Aim: To investigate the co-existence of cholelithiasis in patients with gastrointestinal (GI) cancer both in preoperative and postoperative periods. Methods: We retrospectively analyzed the data of patients who underwent GI tract cancer surgery in the general surgery clinic of a university hospital between January 2013 and December 2019 for the presence of 'cholelithiasis' in the preoperative and postoperative periods. Age, gender, tumor type and localization and presence of the cholelithiasis in the patients were determined. In addition, the cases were divided into two as upper GI tract and lower GI tract according to tumor location and the relationship with cholelithiasis was evaluated. Results: A total of 680 GI cancer patients were included in the study. Localization of GI cancers were; colon in 211 cases (31%), rectum in 195 cases (28.7%), gastric in 187 cases (27.5%), periampullary region in 55 cases (8.1%), and small intestine in 32 cases (4.7%). In the preoperative period, 69 (10.1%) patients were associated with cholelithiasis. Thirty-one (5.1%) patients had accompanying cholelithiasis in the postoperative period. Coexistence of cholelithiasis according to cancer location was not statistically significant in the preoperative and postoperative periods. Conclusions: Our available data make it difficult to distinguish the roles of cholelithiasis on gastrointestinal cancers, because no statistically causal relationship was found between cholelithiasis and gastrointestinal cancers. However, the role of asymptomatic and symptomatic stones, which may or may not require cholecystectomy, in the development of GI tract cancers should not be ignored.

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Bu Makaleye Atıf Yap

ÖZER, B., ÇATAL, O., ÖZER, S. P., KEYİF, F., ŞİT, M., KAMA, N. (2020). Cholelithiasis and gastrointestinal cancer: Is there a relationship that increases the risk of developing cancer?. Experimental Biomedical Research, Cilt: 3 - Sayı: 4, 248–254. https://ajindex.com/articles/160985

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Kaynakça (16)

  1. Brett M, Barker D. The world distribution of gallstones. Int J Epidemiol. 1976;5(4):335- 41
  2. Nakeeb A, Comuzzie AG, Martin L, et al. Gallstones: genetics versus environment. Ann Surg. 2002;235(6):842-49
  3. Al-Jiffry BO, Shaffer EA, Saccone GT, et al. Changes in gallbladder motility and gallstone formation following laparoscopic gastric banding for morbid obesity. Can J Gastroenterol Hepatol. 2003;17(3):169-74
  4. Xu Y-K, Zhang F-L, Feng T, et al. Metaanalysis on the correlation of cholecystectomy or cholecystolithiasis to risk of colorectal cancer in Chinese population. Chin J Cancer. 2009; 28(7):749- 55 [5] Chiong C, Cox MR, Eslick GD. Gallstone disease is associated with rectal cancer: a meta-analysis. Scand J Gastroenterol. 2012;47(5):553-64
  5. Tavani A, Rosato V, Di Palma F, et al. History of cholelithiasis and cancer risk in a network of case–control studies. Ann Oncol. 2012;23(8):2173-178
  6. Giovannucci E, Colditz GA, Stampfer MJ. A meta-analysis of cholecystectomy and risk of colorectal cancer. Gastroenterol. 1993;105(1):130-41
  7. Linos D, O'Fallon WM, Heart JR R, et al. Cholecystectomy and carcinoma of the colon. The Lancet. 1981;318(8243):379-81
  8. Chen Y-K, Yeh J-H, Lin C-L, et al. Cancer risk in patients with cholelithiasis and after cholecystectomy: a nationwide cohort study. J Gastroenterol. 2014;49(5):923-31
  9. Nogueira L, Freedman ND, Engels EA, et al. Gallstones, cholecystectomy, and risk of digestive system cancers. Am J Epidemiol. 2014;179(6):731-39
  10. Schmidt M, Småstuen MC, Søndenaa K. Increased cancer incidence in some gallstone diseases, and equivocal effect of cholecystectomy: a long-term analysis of cancer and mortality. Scand J Gastroenterol. 2012;47(12):1467-474
  11. Yamaji Y, Okamoto M, Yoshida H, et al. Cholelithiasis is a risk factor for colorectal adenoma. Am J Gastroenterol. 2008;103(11):2847-852
  12. Kahn HS, Tatham LM, Thun MJ, et al. Risk factors for self-reported colon polyps. J Gen Intern Med. 1998;13(5):303-10
  13. Ross R, Hartnett N, Bernstein L, et al. Epidemiology of adenocarcinomas of the small intestine: is bile a small bowel carcinogen? Br J Cancer. 1991;63(1):143- 45
  14. Imray C, Radley S, Davis A, et al. Faecal unconjugated bile acids in patients with colorectal cancer or polyps. Gut. 1992;33(9):1239-245
  15. Tocchi A, Basso L, Costa G, et al. Is there a causal connection between bile acids and colorectal cancer? Surg Today. 1996;26(2):101-104
  16. Berr F, Stellaard F, Pratschke E