Dergiler / Experimental Biomedical Research / 2020 / Cilt: 3 - Sayı: 4

Responses of salivary cortisol levels and sedation score to oral hydroxyzine premedication in children undergoing outpatient surgery

Sayfa
285–292
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Moreover, different types of surgery appear to be perceived as similar threats by the children.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:Aim: To evaluate the sedation score response and salivary cortisol levels (SC) to premedication with sedative hydroxyzine in children with outpatient surgery and the relationships between the two.
📊
Temel Bulgular & Veri:Methods: Eighty-seven ASA 1 classified patients (American Society of Anesthesiologists Classification 1, normal healthy patients), aged 4-13 years, were randomly and prospectively allocated into the study.
💡
Sonuç & Katkı:Moreover, different types of surgery appear to be perceived as similar threats by the children.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

Aim: To evaluate the sedation score response and salivary cortisol levels (SC) to premedication with sedative hydroxyzine in children with outpatient surgery and the relationships between the two. Methods: Eighty-seven ASA 1 classified patients (American Society of Anesthesiologists Classification 1, normal healthy patients), aged 4-13 years, were randomly and prospectively allocated into the study. Children having outpatient surgery (e.g. inguinal/abdominal surgery, circumcision) either did not have a premedication or received oral hydroxyzine (2 h before the surgery) as a sedative drug. All patients were evaluated for the level of sedation by Ramsay sedation score [RSS, from 1 (awake, anxious, restless or both) to 6 (asleep, exhibits no response)] by an independent anesthesiologist. Salivary samples taken during the assessment of sedation score were analyzed for cortisol levels. Results: SC increased significantly by increasing age (r=0.447; p 0.05). Conclusion: The data suggest that salivary cortisol increases by increased age and provide evidence that sedation is associated with suppressed cortisol levels. Moreover, different types of surgery appear to be perceived as similar threats by the children.

🔖

Bu Makaleye Atıf Yap

CEVİZCİ, M. N., UÇAR, C. (2020). Responses of salivary cortisol levels and sedation score to oral hydroxyzine premedication in children undergoing outpatient surgery. Experimental Biomedical Research, Cilt: 3 - Sayı: 4, 285–292. https://ajindex.com/articles/159495

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (14)

  1. Abdallah C, Hannallah R. Premedication of the child undergoing surgery. Middle East J Anaesthesiol. 2011; 21(2): 165-74
  2. Kain ZN, Mayes LC, Caldwell-Andrews AA, et al. Preoperative anxiety, postoperative pain, and behavioral recovery in young children undergoing surgery. Pediatrics. 2006;118(2):651-58
  3. Vinita S, Manu P, Singh GP. Oral midazolam and oral butorphanol premedication. Indian J Pediatr. 2005;72(9):741-44
  4. Merriman HM. The techniques used to sedate ventilated patients. A survey of methods used in 34 ICUs in Great Britain. Intensive Care Med. 1981;7(5):217- 24
  5. Shapira J, Kupietzky A, Kadari A, et al. Comparison of oral midazolam with and without hydroxyzine in the sedation of pediatric dental patients. Pediatr Dent. 2004; 26(6):492-96
  6. Kupietzky A, Holan, G, Shapiro J. Intranasal midazolam better at effecting amnesia after sedation than oral hydroxyzine: A pilot study. Pediatr Dent. 1996;18(8):32-34
  7. Kara D, Bayrak NA, Volkan B, et al. Anx􀵴ety and Sal􀵴vary Cort􀵴sol Levels 􀵴n Ch􀵴ldren Undergo􀵴ng Esophago-Gastro- Duodenoscopy Under Sedat􀵴on. J Ped􀵴atr Gastroenterol Nutr. 2019;68(1):3-6
  8. Blair C, Raver CC. Closing the achievement gap through modification of neurocognitive and neuroendocrine function: Results from a cluster randomized controlled trial of an ınnovative approach to the education of children in kindergarten. PloS one. 2014; 9(11): e112393
  9. Petrowski K, Schmalbach B, Niedling M, et al. The effects of post-awakening light exposure on the cortisol awakening response in healthy male individuals. Psychoneuroendocrinology. 2019;108:28-34
  10. Ozgocer T, Yildiz S, Uçar C. Development and validation of an enzyme-linked immunosorbent assay for detection of cortisol in human saliva. J Immunoassay Immunochem. 2017; 38(2): 147-64
  11. Le Rouxa F, Lipskerb A, Mesureurc S, et al. Inguinal hernia repair in children: Surgical technique. J Visc Surg. 2016; 153 (2): 121- 25
  12. Köner O1, Türe H, Mercan A, et al. Effects of hydroxyzine-midazolam premedication on sevoflurane-induced paediatric emergence agitation: a prospective randomised clinical trial. Eur J Anaesthesiol. 2011; 28(9): 640-45
  13. Kudielka BM, Hellhammer DH, Wüst S. Why do we respond so differently? Reviewing determinants of human salivary cortisol responses to challenge. Psychoneuroendocrinology. 2009; 34(1): 2- 18
  14. Gatti R, Antonelli G, Prearo M, et al. Cortisol assays and diagnostic laboratory procedures in human biological fluids. Clin Bio