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1. Kaynaklar 1-Staessen JA, Fagard R, Thijs L, Celis H, Arabidze GG, BirkenhägerWH, et al. Randomised double-blind comparison of placebo and ac-tive treatment for older patients with isolated systolic hypertension.The Systolic Hypertension in Europe (Syst-Eur) Trial Investigators.Lancet. 1997 Sep 13;350(9080):757-64. 2-Prevention of stroke by antihypertensive drug treatment in older per-sons with isolated systolic hypertension. Final results of the Systo-lic Hypertension in the Elderly Program (SHEP). SHEP Coopera-tive Research Group.[No authors listed] JAMA. 1991 Jun26;265(24):3255-64. 3-Boutitie F, Gueyffier F, Pocock S, Fagard R, Boissel JP, INDANAProject Steering Committee. INdividual Data ANalysis of Antihyper-tensive intervention J-shaped relationship between blood pressureand mortality in hypertensive patients: new insights from a meta-analy-sis of individual-patient data. Ann Intern Med. 2002;136(6):438. 4-Staessen J, Bulpitt C, Clement D, De Leeuw P, Fagard R, FletcherA, et al. Relation between mortality and treated blood pressure inelderly patients with hypertension: report of the European WorkingParty on High Blood Pressure in the Elderly. BMJ.1989;298(6687):1552. 5-Arguedas JA, Perez MI, Wright JM. Treatment blood pressure tar-gets for hypertension. Cochrane Database Syst Rev. 2009 Jul 8;(3) 6-Cushman WC, Evans GW, Byington RP, Goff DC Jr, Grimm RH Jr,Cutler JA, et al. ACCORD Study Group. Effects of intensive blood-pressure control in type 2 diabetes mellitus. N Engl J Med. 2010 Apr29;362(17):1575-85 7-Sundström J, Arima H, Woodward M, Jackson R, Karmali K, Lloyd-Jones D, et al. Blood Pressure Lowering Treatment Trialists' Col-laboration. Blood pressure-lowering treatment based on cardiovas-cular risk: a meta-analysis of individual patient data. Lancet. 2014Aug 16;384(9943):591-8. 8-Ogihara T, Saruta T, Rakugi H, Matsuoka H, Shimamoto K, Shima-da K, et al. Valsartan in Elderly Isolated Systolic Hypertension StudyGroup. Hypertension. 2010 Aug;56(2):196-202. 9-Wright JT Jr, Williamson JD, Whelton PK, Snyder JK, Sink KM, Roc-co MV, et al. A Randomized Trial of Intensive versus Standard Blo-od-Pressure Control. SPRINT Research Group. N Engl J Med.2015;373(22):2103. 10-SPRINT Research Group, Wright JT Jr, Williamson JD, Whelton PK,Snyder JK, Sink KM, Rocco MV et al. A Randomized Trial of Inten-sive versus Standard Blood-Pressure Control N Engl J Med 2015;373:2103-2116 10, 26, 2015 11-Xie X, Atkins E, Lv J, Bennett A, Neal B, Ninomiya T et al. Effectsof intensive blood pressure lowering on cardiovascular and renal out-comes: updated systematic review and meta-analysis. Lancet.2016;387:435–443 12-Blood Pressure Targets in Subjects With Type 2 Diabetes Mellitus/Im-paired Fasting Glucose Observations From Traditional and Baye-sian Random-Effects Meta-Analyses of Randomized Trials Sripal Ban-galore, MD, MHA; Sunil Kumar, MD; Iryna Lobach, PhD; FranzH. Messerli, MD. 13-Jones DW. What should be the target blood pressure for CKD withovert proteinuria? J Hypertens. 2016 Sep;34 14-Franklin SS, Gokhale SS, Chow VH, Larson MG, Levy D, Vasan RSet al. Does low diastolic blood pressure contribute to the risk of re-current hypertensive cardiovascular disease events? The Framing-ham Heart Study. Hypertension, 2015 feb:65(2);299-305 15-Mancia G, Fagard R, Narkiewicz K, Redón J, Zanchetti A, Böhm Met al; Task Force Members. 2013 ESH/ESC Guidelines for the ma-nagement of arterial hypertension: the Task Force for the manage-ment of arterial hypertension of the European Society of Hyperten-sion (ESH) and of the European Society of Cardiology (ESC).J Hyper-tens. 2013;31:1281–1357. 16-James PA, Oparil S, Carter BL, Cushman WC, Dennison-Himmel-farb C, Handler J et al. 2014 evidence-based guideline for the ma-nagement of high blood pressure in adults: report from the panel mem-bers appointed to the Eighth Joint National Committee (JNC 8). JAMA.2014;311:507–520
2. Kaynaklar 1-Staessen JA, Fagard R, Thijs L, Celis H, Arabidze GG, BirkenhägerWH, et al. Randomised double-blind comparison of placebo and ac-tive treatment for older patients with isolated systolic hypertension.The Systolic Hypertension in Europe (Syst-Eur) Trial Investigators.Lancet. 1997 Sep 13;350(9080):757-64. 2-Prevention of stroke by antihypertensive drug treatment in older per-sons with isolated systolic hypertension. Final results of the Systo-lic Hypertension in the Elderly Program (SHEP). SHEP Coopera-tive Research Group.[No authors listed] JAMA. 1991 Jun26;265(24):3255-64. 3-Boutitie F, Gueyffier F, Pocock S, Fagard R, Boissel JP, INDANAProject Steering Committee. INdividual Data ANalysis of Antihyper-tensive intervention J-shaped relationship between blood pressureand mortality in hypertensive patients: new insights from a meta-analy-sis of individual-patient data. Ann Intern Med. 2002;136(6):438. 4-Staessen J, Bulpitt C, Clement D, De Leeuw P, Fagard R, FletcherA, et al. Relation between mortality and treated blood pressure inelderly patients with hypertension: report of the European WorkingParty on High Blood Pressure in the Elderly. BMJ.1989;298(6687):1552. 5-Arguedas JA, Perez MI, Wright JM. Treatment blood pressure tar-gets for hypertension. Cochrane Database Syst Rev. 2009 Jul 8;(3) 6-Cushman WC, Evans GW, Byington RP, Goff DC Jr, Grimm RH Jr,Cutler JA, et al. ACCORD Study Group. Effects of intensive blood-pressure control in type 2 diabetes mellitus. N Engl J Med. 2010 Apr29;362(17):1575-85 7-Sundström J, Arima H, Woodward M, Jackson R, Karmali K, Lloyd-Jones D, et al. Blood Pressure Lowering Treatment Trialists' Col-laboration. Blood pressure-lowering treatment based on cardiovas-cular risk: a meta-analysis of individual patient data. Lancet. 2014Aug 16;384(9943):591-8. 8-Ogihara T, Saruta T, Rakugi H, Matsuoka H, Shimamoto K, Shima-da K, et al. Valsartan in Elderly Isolated Systolic Hypertension StudyGroup. Hypertension. 2010 Aug;56(2):196-202. 9-Wright JT Jr, Williamson JD, Whelton PK, Snyder JK, Sink KM, Roc-co MV, et al. A Randomized Trial of Intensive versus Standard Blo-od-Pressure Control. SPRINT Research Group. N Engl J Med.2015;373(22):2103. 10-SPRINT Research Group, Wright JT Jr, Williamson JD, Whelton PK,Snyder JK, Sink KM, Rocco MV et al. A Randomized Trial of Inten-sive versus Standard Blood-Pressure Control N Engl J Med 2015;373:2103-2116 10, 26, 2015 11-Xie X, Atkins E, Lv J, Bennett A, Neal B, Ninomiya T et al. Effectsof intensive blood pressure lowering on cardiovascular and renal out-comes: updated systematic review and meta-analysis. Lancet.2016;387:435–443 12-Blood Pressure Targets in Subjects With Type 2 Diabetes Mellitus/Im-paired Fasting Glucose Observations From Traditional and Baye-sian Random-Effects Meta-Analyses of Randomized Trials Sripal Ban-galore, MD, MHA; Sunil Kumar, MD; Iryna Lobach, PhD; FranzH. Messerli, MD. 13-Jones DW. What should be the target blood pressure for CKD withovert proteinuria? J Hypertens. 2016 Sep;34 14-Franklin SS, Gokhale SS, Chow VH, Larson MG, Levy D, Vasan RSet al. Does low diastolic blood pressure contribute to the risk of re-current hypertensive cardiovascular disease events? The Framing-ham Heart Study. Hypertension, 2015 feb:65(2);299-305 15-Mancia G, Fagard R, Narkiewicz K, Redón J, Zanchetti A, Böhm Met al; Task Force Members. 2013 ESH/ESC Guidelines for the ma-nagement of arterial hypertension: the Task Force for the manage-ment of arterial hypertension of the European Society of Hyperten-sion (ESH) and of the European Society of Cardiology (ESC).J Hyper-tens. 2013;31:1281–1357. 16-James PA, Oparil S, Carter BL, Cushman WC, Dennison-Himmel-farb C, Handler J et al. 2014 evidence-based guideline for the ma-nagement of high blood pressure in adults: report from the panel mem-bers appointed to the Eighth Joint National Committee (JNC 8). JAMA.2014;311:507–520