Non-steroidal anti-inflammatory drug supplementation modulates lipid peroxidation and total antioxidant levels in serum of patients with primary dysmenorrhea

Abstract

Dysmenorrhea is a common painful gynecological disorder in young women during menstrual cycle. Inflammation and oxidative toxicity were reported in the patients with primary dysmenorrhea although its etiology is still unclear. We investigated effects of non-steroidal anti-inflammatory drug (NSAID) supplementation on lipid peroxidation, total antioxidant status (TAS) and antioxidant vitamin values in serum of patients with primary dysmenorrhea. We used three groups in this study. First group was used as control. Second group constituted patients (primary dysmenorrhea) group. Third group was daily received oral NSAID for 6 weeks before blood serum taken. The lipid peroxidation level was higher in patient group than in control although its level was lower in treatment group than in control group. The TAS concentrations were lower in patients group than in control. However, TAS and vitamin C concentrations were higher in treatment group than in patient group. Serum vitamin A, vitamin E and -carotene concentrations did not differ in the three groups. In conclusion, we observed that women with primary dysmenorrhea are a consideration with increased oxidative stress in serum. The NSAID supplementation in serum of women may strengthen the antioxidant defense system by decreasing oxidative stress.