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Dergiler / Veterinary Sciences and Practices / 2026 / Cilt: 14 Sayı: 2

Kök Hücre

Stem Cell

Ece Çerci(VETERİNER FAKÜLTESİ)
Hatice Erdost(VETERİNER FAKÜLTESİ)
Sayfa
221–228
Yayın Tarihi
2019-10-25
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Bu derlemede; kök hücre, kök hücrelerin potansiyel kullanım alanları ve özellikle veteriner hekimlikteki uygulamaları yer almaktadır.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:Doku ve organlarda bulunan, kendini yenileyebilen ve canlının ihtiyacına göre farklılaşarak diğer doku hücrelerine dönüşebilen ve çoğalabilen hücreler ‘‘Kök Hücre’’ olarak tanımlanır.
📊
Temel Bulgular & Veri:Embriyonik olmayan kök hücreler fötal kök hücrelerden, kadavradan, göbek kordonundan, plasentadan, kemik iliğinden, yağ dokudan, pekçok organda bulunan kök hücrelerden (somatik kök hücreler) veya son yıllarda farklılaştırma ile herhangi bir hücrenin kök hücre haline dönüştürülmesiyle oluşan hücrelerden elde edilebilmektedir.
💡
Sonuç & Katkı:Bu derlemede; kök hücre, kök hücrelerin potansiyel kullanım alanları ve özellikle veteriner hekimlikteki uygulamaları yer almaktadır.
🔬Tür:Deneysel Tarla Denemesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Erişkin Hücre · Pluripotent · Totipotent

Özet

Doku ve organlarda bulunan, kendini yenileyebilen ve canlının ihtiyacına göre farklılaşarak diğer doku hücrelerine dönüşebilen ve çoğalabilen hücreler ‘‘Kök Hücre’’ olarak tanımlanır. Kök hücreler; embriyonik kök hücrelerden ve embriyonik olmayan kök hücrelerden elde edilebilir. Embriyonik olmayan kök hücreler fötal kök hücrelerden, kadavradan, göbek kordonundan, plasentadan, kemik iliğinden, yağ dokudan, pekçok organda bulunan kök hücrelerden (somatik kök hücreler) veya son yıllarda farklılaştırma ile herhangi bir hücrenin kök hücre haline dönüştürülmesiyle oluşan hücrelerden elde edilebilmektedir. Totipotent, pluripotent ve yetişkin mezenkimal kök hücreler rejeneratif tıp, doku mühendisliği, veteriner hekimliği ile biyomühendislik alanları tarafından büyük ilgi görmektedir. Mezenkimal kök hücrelerin sağlıklı, ekonomik olarak çoğaltılabilmesi, ihtiyaç duyulan hücre tiplerine dönüştürülebilmesi, kök hücrelerin insan ve hayvanlarda tedavi amaçlı kullanımını mümkün kılacaktır. Bu derlemede; kök hücre, kök hücrelerin potansiyel kullanım alanları ve özellikle veteriner hekimlikteki uygulamaları yer almaktadır.

Abstract

'' Stem Cell'' is defined as the cell which are found in a tissue or organ which can renew and replicate themselves according to the needs of the body and differentiate into other tissue cells. Stem cells can be obtained from embryonic stem cells and non‐embryonic stem cells. Non‐embryonic stem cells can be obtained from fetal stem cells, cadavers, umbilical cord, placenta, bone marrow, adipose tissue and in many organs (somatic stem cells) or in recent years, differentiation can be obtained from cells formed by transdifferentiating any cell into stem cells. Totipotent, pluripotent and adult mesenchymal stem cells are of great interest by regenerative medicine, tissue engineering, veterinary and bioengineering fields. The ability to reproduce mesenchymal stem cells in healthy, economically, and differentiate them into needed cell types will enable the use of stem cells in order to support the regeneration in humans and animals. This review covers the informations about stem cell, potential use of stem cells and their applications especially in veterinary medicine.

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Bu Makaleye Atıf Yap

Çerci, E., Erdost, H. (2019). Kök Hücre. Veterinary Sciences and Practices, Cilt: 14 Sayı: 2, 221–228. https://ajindex.com/articles/1580679

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Kaynakça (90)

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  2. Aragona M., Maisano R., Panetta S., Giudice A., Morelli M., La Torre I., La Torre F., 2000. Telomere length maintenance in aging and carcinogenesis, Int J Oncol, 17, 981–989
  3. Huang S., Fu R., Shyu W., 2013. Adipose‐derived stem cells: Isolation, characterization, and differentiation potential. Cell Transplant, 22, 701‐ 709
  4. Morgani SM., Canham MA., Nichols J., Sharov A. A., Migueles RP., Ko MS., Brickman JM., 2013. Totipotent embryonic stem cells arise in groundstate culture conditions. Cell Rep, 3, 1945‐1957
  5. Friedenstein A., Gorskaja J., Kulagina N., 1976. Fibroblast precursors in normal and irradiated mouse hematopoietic organs, Exp Hematol, 4, 267‐274
  6. Erdost H., Çerçi E., 2018. Immunohistochemical localization of Ki67 antibody derived by adipose tissue, ISMSIT, 385‐392
  7. Hoogduijn MJ., 2015. Are mesenchymal stromal cells immune cells?, Arthritis Res Ther, 17, 88
  8. Özen A., Gül Sancak İ., Ceylan A., Özgenç Ö., 2016. Isolation of adipose tissue‐derived stem cells. Turkish J Vet Anim Sci, 40, 137–141
  9. Çerçi E., Erdost H., 2016. Adipose tissue derived mesenchymal stem cells from rat with nonenzymatic isolation method. CBU‐SBED, 3:(2), 299‐302
  10. Mauro A., 1961. Satellite cell of skeletal muscle fibers. J Biophys Biochem Cytol, 9, 493‐495
  11. Krause D., 2002. Plasticity of marrow‐derived stem cells. Gene Ther. 9,754‐758
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  13. Karathanasis SK., 2014. Regenerative medicine: Transforming the drug discovery and development paradigm. Cold Spring Harb Perspect Med, 4, 1‐11
  14. Zuk PA., Zhu M., Mizuno H., Huang J., Futrell JW., Katz AJ., Benhaim P., Lorenz HP., Hedrick MH. 2001. Multilineage cells from human adipose tissue: implications for cell‐based therapies, Tissue Eng, 7, 211‐228
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  20. Sichien D., Lambrecht BN., Guilliams M., Scott CL., 2017. Development of conventional dendritic cells: From common bone marrow progenitors to multiple subsets in peripheral tissues. Mucosal Immunol, 10, 831‐844
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  24. Erdost H., Çerçi E., 2018. Growth curve of mesenchymal stem cell originated from adipose tissue. ISMSIT, 393‐397
  25. Munir H., Ward LSC., Sheriff L., Kemble S., Nayar S., Barone F., Gerard B. Nash, McGettrick H.M., 2017. Adipogenic differentiation of mesenchymal stem cells alters their immunomodulatory properties in a tissue‐specific manner. Stem Cells, 35, 1636–1646
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  27. Badimon L., Onate B., Vilahur G., 2015. Adiposederived mesenchymal stem cells and their reparative potential in ischemic heart disease.Rev Esp Cardiol (Engl Ed), 68, 599‐611
  28. Christ GJ., Saul JM., Furth ME., Andersson KE., 2013. The pharmacology of regenerative medicine. Pharmacol Rev, 65, 1091‐1133
  29. Duncan T., Valenzuela M., 2017. Alzheimer's disease, dementia, and stem cell therapy. Stem Cell Res Ther, 8, 111
  30. Henning RJ., 2018. Current status of stem cells in cardiac repair. Future Cardiol, 14, 181‐192
  31. Fang Y., Gao T., Zhang B., Pu J., 2018. Recent advances: Decoding Alzheimer's disease with stem cells. Front Aging Neurosci, 10, 77
  32. Peng BY., Dubey NK., Mishra VK., Tsai FC., Dubey R., Deng WP., Wei HJ., 2018. Addressing Stem Cell Therapeutic Approaches in Pathobiology of Diabetes and Its Complications. J Diabetes Res, Article ID 7806435, 16
  33. Muraro PA., Martin R., Mancardi GL., Nicholas R., Sormani MP., Saccardi R., 2017. Autologous haematopoietic stem cell transplantation for treatment of multiple sclerosis. Nat Rev Neurol, 13, 391‐405
  34. Zhang XM., Zhang YJ., Wang W., Wei YQ., Deng HX., 2017. Mesenchymal stem cells to treat crohn's disease with fistula. Hum Gene Ther, 28, 534‐540
  35. Shi Y., Wang Y., Li Q., Liu K., Hou J., Shao C., Wang Y., 2018. Immunoregulatory mechanisms of mesenchymal stem and stromal cells in inflammatory diseases. Nat Rev Nephrol, 14, 493‐ 507
  36. Markoski MM., 2016. Advances in the use of stem cells in Veterinary medicine: from basic research to clinical practice. Scientifica (Cairo), 4516920
  37. Nam Y., Rim YA., Lee J., Ju JH. 2018. Current therapeutic strategies for stem cell‐based cartilage regeneration. Stem cells Int, 8490489
  38. Ouyang H., Goldberg JL., Chen S., Li W., Xu G‐T, Li W., Zhang K., Nussenblatt RB., Liu Y., Xie T., Chan C‐C, Zack DJ, 2016. Ocular stem cell research from basic science to clinical application: A report from zhongshan ophthalmic center ocular stem cell symposium. Int J Mol Sci, 17, 415
  39. Zheng J., Wang Q., Leng W., Sun X., Peng J., 2018. Bone marrow‐derived mesenchymal stem cell‐conditioned medium attenuates tubulointerstitial fibrosis by inhibiting monocyte mobilization in an irreversible model of unilateral ureteral obstruction. Mol Med Reports, 17, 7701‐ 7707
  40. Fang Y., Gao T., Zhang B., Pu J., 2018. Recent advances: Decoding Alzheimer's disease with stem cells. Front Aging Neurosci, 10, 77
  41. Spaas JH., Broeckx S., Van De Walle GR., Polettini M., 2013. The effects of equine peripheral blood stem cells on cutaneous wound healing: A clinical evaluation in four horses, Clin Exp Dermatol, 38, 280‐284
  42. Guercio A., Di Marco P., Casella S., Russotto L., Puglisi F., Majolino C., Giudice SD., Purpari G., Cannella V., Piccione G., 2015. Mesenchymal stem cells derived from subcutaneous fat and platelet‐rich plasma used in athletic horses with lameness of the superficial digital flexor tendon. J Equine Vet Sci, 35, 19‐26
  43. Morcos MW., Al‐Jallad H., Hamdy R., 2015. Comprehensive review of adipose stem cells and their implication in distraction osteogenesis and bone regeneration. Biomed Res Int,1‐20
  44. Vilar JM., Batista M., Morales M., Santana A., Cuervo B., Rubio M., Cugat R., Sopena J., Carrillo JM., 2014. Assessment of the effect of intraarticular injection of autologous adiposederived mesenchymal stem cells in osteoarthritic dogs using a double blinded force platform analysis. BMC Vet Res, 10, 1‐7
  45. Kirkby KA., Lewis DD., 2012. Canine hip dysplasia: Reviewing the evidence for nonsurgical management. Vet Surg, 41, 2‐9
  46. Okarma T., 1998. Human primordial stem cells, Hastings Cent Rep, 104, 30
  47. Aragona M., Maisano R., Panetta S., Giudice A., Morelli M., La Torre I., La Torre F., 2000. Telomere length maintenance in aging and carcinogenesis, Int J Oncol, 17, 981–989
  48. Huang S., Fu R., Shyu W., 2013. Adipose‐derived stem cells: Isolation, characterization, and differentiation potential. Cell Transplant, 22, 701‐ 709
  49. Morgani SM., Canham MA., Nichols J., Sharov A. A., Migueles RP., Ko MS., Brickman JM., 2013. Totipotent embryonic stem cells arise in groundstate culture conditions. Cell Rep, 3, 1945‐1957
  50. Friedenstein A., Gorskaja J., Kulagina N., 1976. Fibroblast precursors in normal and irradiated mouse hematopoietic organs, Exp Hematol, 4, 267‐274
  51. Erdost H., Çerçi E., 2018. Immunohistochemical localization of Ki67 antibody derived by adipose tissue, ISMSIT, 385‐392
  52. Hoogduijn MJ., 2015. Are mesenchymal stromal cells immune cells?, Arthritis Res Ther, 17, 88
  53. Özen A., Gül Sancak İ., Ceylan A., Özgenç Ö., 2016. Isolation of adipose tissue‐derived stem cells. Turkish J Vet Anim Sci, 40, 137–141
  54. Çerçi E., Erdost H., 2016. Adipose tissue derived mesenchymal stem cells from rat with nonenzymatic isolation method. CBU‐SBED, 3:(2), 299‐302
  55. Mauro A., 1961. Satellite cell of skeletal muscle fibers. J Biophys Biochem Cytol, 9, 493‐495
  56. Krause D., 2002. Plasticity of marrow‐derived stem cells. Gene Ther. 9,754‐758
  57. Erdost H., 2017. Mezenkimal Kök Hücre, 1. baskı, ''Kök Hücre'', Dora Yayınları, 15‐18, Bursa, Türkiye
  58. Karathanasis SK., 2014. Regenerative medicine: Transforming the drug discovery and development paradigm. Cold Spring Harb Perspect Med, 4, 1‐11
  59. Zuk PA., Zhu M., Mizuno H., Huang J., Futrell JW., Katz AJ., Benhaim P., Lorenz HP., Hedrick MH. 2001. Multilineage cells from human adipose tissue: implications for cell‐based therapies, Tissue Eng, 7, 211‐228
  60. Chen Z., Chang M., Peng Y., Zhao L., Zhan Y., Wang LJ., Wang R., 2007. Osteogenic growth peptide Cterminal pentapeptide [OGP(10‐14)] acts on rat bone marrow mesenchymal stem cells to promote differentiation to osteoblasts and to inhibit differentiation to adipocytes, Regul Pept, 142, 16‐23
  61. Colter D., Class R., Di Girolam C., Prockop D., 2000. Rapid expansion of recycling stem cells in cultures of plastic‐adherent cells from human bone marrow. Proc Natl Acad Sci U S A, 28, 3213‐3218
  62. Cuiffo BG., Karnoub AE., 2012. Mesenchymal stem cells in tumor development: emerging roles and concepts. Cell Adh Migr, 6, 220‐230
  63. Szöke K., Dankova J., Buzgo M., Amler E., Brinchmann JE., Ostrup E., 2017. The effect of medium composition on deposition of collagen type 1 and expression of osteogenic genes in mesenchymal stem cells derived from human adipose tissue and bone marrow. Process Biochem, 59, 321‐328
  64. Li C., Wu X., Tong J., Yang X., Zhao J., Zheng Q., Zhao G., Ma Z., 2015. Comparative analysis of human mesenchymal stem cells from bone marrow and adipose tissue under xeno‐free conditions for cell therapy. Stem Cell Res Ther, 6,55
  65. Sichien D., Lambrecht BN., Guilliams M., Scott CL., 2017. Development of conventional dendritic cells: From common bone marrow progenitors to multiple subsets in peripheral tissues. Mucosal Immunol, 10, 831‐844
  66. Abou‐Saleh H., Zouein FA., El‐Yazbi A., Sanoudou D., Raynaud C., Rao C., Pintus G., Dehaini H., Eid AH., 2018. The march of pluripotent stem cells in cardiovascular regenerative medicine. Stem Cell Res Ther, 9, 201
  67. Yang C., Li J., Lin H., Zhao K., Zheng C., 2015. Nasal mucosa derived‐mesenchymal stem cells from mice reduce inflammation via modulating immune responses. PLoS One, 10, 1‐11
  68. Weissman I., 2016. Linked references are available on JSTOR for this article: Translating stem and progenitor to the clinic: barriers and opportunities. Science, 287(5457), 1442–1446
  69. Erdost H., Çerçi E., 2018. Growth curve of mesenchymal stem cell originated from adipose tissue. ISMSIT, 393‐397
  70. Munir H., Ward LSC., Sheriff L., Kemble S., Nayar S., Barone F., Gerard B. Nash, McGettrick H.M., 2017. Adipogenic differentiation of mesenchymal stem cells alters their immunomodulatory properties in a tissue‐specific manner. Stem Cells, 35, 1636–1646
  71. Erdost H., Çerçi E., İlhan T., Özgüden Akkoç CG., 2017. Use of mesenchymal stem cells originated from fat tissue in bone tissue regeneration. III. International Stem Cell Symposium; New Approaches to Stem Cell Application in Patient‐Based Therapy, pp:76‐77, Manisa, Turkey
  72. Badimon L., Onate B., Vilahur G., 2015. Adiposederived mesenchymal stem cells and their reparative potential in ischemic heart disease.Rev Esp Cardiol (Engl Ed), 68, 599‐611
  73. Christ GJ., Saul JM., Furth ME., Andersson KE., 2013. The pharmacology of regenerative medicine. Pharmacol Rev, 65, 1091‐1133
  74. Duncan T., Valenzuela M., 2017. Alzheimer's disease, dementia, and stem cell therapy. Stem Cell Res Ther, 8, 111
  75. Henning RJ., 2018. Current status of stem cells in cardiac repair. Future Cardiol, 14, 181‐192
  76. Fang Y., Gao T., Zhang B., Pu J., 2018. Recent advances: Decoding Alzheimer's disease with stem cells. Front Aging Neurosci, 10, 77
  77. Peng BY., Dubey NK., Mishra VK., Tsai FC., Dubey R., Deng WP., Wei HJ., 2018. Addressing Stem Cell Therapeutic Approaches in Pathobiology of Diabetes and Its Complications. J Diabetes Res, Article ID 7806435, 16
  78. Muraro PA., Martin R., Mancardi GL., Nicholas R., Sormani MP., Saccardi R., 2017. Autologous haematopoietic stem cell transplantation for treatment of multiple sclerosis. Nat Rev Neurol, 13, 391‐405
  79. Zhang XM., Zhang YJ., Wang W., Wei YQ., Deng HX., 2017. Mesenchymal stem cells to treat crohn's disease with fistula. Hum Gene Ther, 28, 534‐540
  80. Shi Y., Wang Y., Li Q., Liu K., Hou J., Shao C., Wang Y., 2018. Immunoregulatory mechanisms of mesenchymal stem and stromal cells in inflammatory diseases. Nat Rev Nephrol, 14, 493‐ 507
  81. Markoski MM., 2016. Advances in the use of stem cells in Veterinary medicine: from basic research to clinical practice. Scientifica (Cairo), 4516920
  82. Nam Y., Rim YA., Lee J., Ju JH. 2018. Current therapeutic strategies for stem cell‐based cartilage regeneration. Stem cells Int, 8490489
  83. Ouyang H., Goldberg JL., Chen S., Li W., Xu G‐T, Li W., Zhang K., Nussenblatt RB., Liu Y., Xie T., Chan C‐C, Zack DJ, 2016. Ocular stem cell research from basic science to clinical application: A report from zhongshan ophthalmic center ocular stem cell symposium. Int J Mol Sci, 17, 415
  84. Zheng J., Wang Q., Leng W., Sun X., Peng J., 2018. Bone marrow‐derived mesenchymal stem cell‐conditioned medium attenuates tubulointerstitial fibrosis by inhibiting monocyte mobilization in an irreversible model of unilateral ureteral obstruction. Mol Med Reports, 17, 7701‐ 7707
  85. Fang Y., Gao T., Zhang B., Pu J., 2018. Recent advances: Decoding Alzheimer's disease with stem cells. Front Aging Neurosci, 10, 77
  86. Spaas JH., Broeckx S., Van De Walle GR., Polettini M., 2013. The effects of equine peripheral blood stem cells on cutaneous wound healing: A clinical evaluation in four horses, Clin Exp Dermatol, 38, 280‐284
  87. Guercio A., Di Marco P., Casella S., Russotto L., Puglisi F., Majolino C., Giudice SD., Purpari G., Cannella V., Piccione G., 2015. Mesenchymal stem cells derived from subcutaneous fat and platelet‐rich plasma used in athletic horses with lameness of the superficial digital flexor tendon. J Equine Vet Sci, 35, 19‐26
  88. Morcos MW., Al‐Jallad H., Hamdy R., 2015. Comprehensive review of adipose stem cells and their implication in distraction osteogenesis and bone regeneration. Biomed Res Int,1‐20
  89. Vilar JM., Batista M., Morales M., Santana A., Cuervo B., Rubio M., Cugat R., Sopena J., Carrillo JM., 2014. Assessment of the effect of intraarticular injection of autologous adiposederived mesenchymal stem cells in osteoarthritic dogs using a double blinded force platform analysis. BMC Vet Res, 10, 1‐7
  90. Kirkby KA., Lewis DD., 2012. Canine hip dysplasia: Reviewing the evidence for nonsurgical management. Vet Surg, 41, 2‐9.