KaydedilenlerDerginizi ekleyin

Dergiler / GORM:Gynecology Obstetrics & Reproductive Medicine / 2020 / Cilt: 26 - Sayı: 1

The Ability of a Single Serum Progesterone Measurement to Predict the Prognosis of First Trimester Pregnancy

Mehmet Nafi SAKAR
Deniz BALSAK
Süreyya DEMİR
Mehmet Sukru BUDAK
Ali Emre TAHAOĞLU
Sinan Emre GÜNGÖR
Emrullah AKAY
Bülent DEMİR
Sayfa
1–5
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

CONCLUSION: A single measurement of progesterone levels in serum can predict the prognosis of a viable first-trimester pregnancy, while it is less effective for identifying non-viable pregnancies.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:OBJECTIVE: There are cases where ultrasonographic evaluation is inadequate in determining firsttrimester healthy pregnancy.
📊
Temel Bulgular & Veri:STUDY DESIGN: A prospective case-control study was conducted between July 2013 and July 2014 in Tertiary Hospital.
💡
Sonuç & Katkı:CONCLUSION: A single measurement of progesterone levels in serum can predict the prognosis of a viable first-trimester pregnancy, while it is less effective for identifying non-viable pregnancies.
🔬Tür:Araştırma Makalesi
📍Kapsam:2013 Verileri
⚙️Değişkenler:Alan Parametreleri

Özet

OBJECTIVE: There are cases where ultrasonographic evaluation is inadequate in determining firsttrimester healthy pregnancy. In these cases, both the patient and the clinician are involved in a worrying expectation. The single serum progesterone measurement was tried to predict pregnancy prognosis in short time period. This study evaluated the predictive value of a single serum progesterone measurement in first-trimester pregnancy loss. STUDY DESIGN: A prospective case-control study was conducted between July 2013 and July 2014 in Tertiary Hospital. The study compared 106 patients with threatened abortion (vaginal bleeding or spotting) before 13 weeks of gestation with 110 healthy control pregnancies. Samples of serum progesterone were obtained on the day each patient was admitted to the hospital. A Beckman-Coulter macro-Enzymelinked immunoassay (ELISA) system was used to measure serum levels of progesterone (Beckman- Coulter, Ireland). RESULTS: Progesterone levels were measured when the patients first visited the hospital and they were followed until the end of the first trimester. Progesterone levels differed significantly (p=0.013) between the two groups. The spontaneous abortion rate was significantly (p=0.044) higher in the case group. Progesterone levels differed significantly (p=0.001) between ongoing pregnancy and spontaneous abortion groups. Using a cut-off level of 10.7 ng/mL, the sensitivity, specificity, and positive and negative predictive values were 92.1%, 44%, 92.6%, and 42.3%, respectively, for viable pregnancies. CONCLUSION: A single measurement of progesterone levels in serum can predict the prognosis of a viable first-trimester pregnancy, while it is less effective for identifying non-viable pregnancies.

🔖

Bu Makaleye Atıf Yap

SAKAR, M. N., BALSAK, D., DEMİR, S., BUDAK, M. S., TAHAOĞLU, A. E., GÜNGÖR, S. E., AKAY, E., DEMİR, B. (2020). The Ability of a Single Serum Progesterone Measurement to Predict the Prognosis of First Trimester Pregnancy. GORM:Gynecology Obstetrics & Reproductive Medicine, Cilt: 26 - Sayı: 1, 1–5. https://ajindex.com/articles/157148

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (13)

  1. Wilcox AJ, Weinberg CR, O’Connor JF, Baird DD, Schlatterer JP, Canfield RE, et al. Incidence of early loss of pregnancy. N Engl J Med. 1988;319(4):189-94
  2. Voedisch AJ, Frederick CE, Nicosia AF, Stovall TG. Early pregnancy loss and ectopic pregnancy. In: Berek JS, editor. Berek & Novak’s Gynecology, 15th ed. Philadelphia: Lippincott Williams & Wilkins; 2012. p. 619-51
  3. Wang X, Chen C, Wang L, Chen D, Guang W, French J. Conception, early pregnancy loss, and time to clinical pregnancy: a population-based prospective study. Fertil Steril. 2003;79(3):577-84
  4. Silver RM, Branch DW, Goldenberg R, Iams JD, Klebanoff MA. Nomenclature for pregnancy outcomes: time for a change. Obstet Gynecol. 2011;118(6):1402-08
  5. Elson J, Salim R, Tailor A, Banerjee S, Zosmer N, Jurkovic D. Prediction of early pregnancy viability in the absence of an ultrasonically detectable embryo. Ultrasound Obstet Gynecol. 2003;21(1):57-61
  6. Brar AK, Frank GR, Kessler CA, Cedars MI, Handwerger S. Progesterone-dependent decidualization of the human endometrium is mediated by cAMP. Endocrine. 1997;6(3):301-07. 7. al-Sebai MA, Kingsland CR, Diver M, Hipkin L, McFadyen IR. The role of a single progesterone measurement in the diagnosis of early pregnancy failure and the prognosis of fetal viability. Br J Obstet Gynecol. 1995; 102(5):364-69
  7. Phipps MG, Hogan JW, Peipert JF, Lambert-Messerlian GM, Canick JA, Seifer DB. Progesterone, inhibin and hCG multiple marker strategy to differentiate viable from nonviable pregnancies. Obstet Gynecol. 2000;95(2):227- 31
  8. Carson SA, Buster JE. Ectopicpregnancy. N Engl J Med. 1993;329(16):1174-81
  9. Midha U, Narang APS, Sofat IB, Avasthi K, Jain M. Serum progesterone levels in abortions. J Obstet Gynecol India. 2002;52(5):47-50
  10. Taghavi AH. Detection of changes of hCG, progesterone and estradiol serum levels in threatened abortion in the first three months of gestation. Iran J Endocrinol Metab. 2004;6(2):163-69
  11. Norwitz ER, Schust DJ, Fisher SJ. Implantation and the survival of early pregnancy. N Engl J Med. 2001;345 (19):1400-08
  12. Arck P, Hansen PJ, Mulac Jericevic B, Piccinni MP, Szekeres-Bartho J. Progesterone during pregnancy: endocrine- immune cross talk in mammalian species and the role of stress. Am J Reprod Immunol. 2007;58(3):268-79
  13. Lek SM, Ku CW, Allen JC Jr, Malhotra R, Tan NS, Østbye T, et al. Validation of serum progesterone 15. Al Mohamady M, Fattah GA, Elkattan E, Bayoumy R, Hamed DA. Correlation of serum ca-125