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Dergiler / Türk Kadın Sağlığı ve Neonatoloji Dergisi / 2026 / Volume: 6 Issue: 3

Polikistik Over Sendromu Fenotiplerine Göre Anti-Müllerian Hormon Değerleri

Anti-Mullerian Hormone According to Polycystic Ovary Syndrome Phenotypes

Serkan Polat(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ANKARA ETLİK ZÜBEYDE HANIM KADIN HASTALIKLARI SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ)0009-0002-7422-9994
Osmna Nuri Erginay(UNIVERSITY OF HEALTH SCIENCES, ANKARA ETLİK ZÜBEYDE HANIM HEALTH RESEARCH CENTER FOR GYNECOLOGICAL DISEASES)0009-0007-9804-1941
Sayfa
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Yayın Tarihi
2024-09-26
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Bulgular: Çalışmaya toplam 118 PKOS hastası katılmıştır.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Amaç: Bu çalışmanın amacı polikistik over sendromlu (PKOS) hastalarda fenotipik özelliklere göre antimüllerian hormon düzeyini araştırmaktır.
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Temel Bulgular & Veri:Anti-mullerain hormon (AMH) düzeyleri fenotip değerlendirmesine göre kaydedilmiştir.
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Sonuç & Katkı:Bulgular: Çalışmaya toplam 118 PKOS hastası katılmıştır.
🔬Tür:Research Article
📍Kapsam:47 hasta
⚙️Değişkenler:Phenotype · polycystic ovary syndrome · anti mullerian hormone

Özet

Amaç: Bu çalışmanın amacı polikistik over sendromlu (PKOS) hastalarda fenotipik özelliklere göre antimüllerian hormon düzeyini araştırmaktır. Gereç ve Yöntemler: Bu çalışma kesitsel bir kohort çalışması olarak tasarlandı ve Etlik Zübeyde Hanım Kadın Hastalıkları Eğitim ve Araştırma Hastanesi PKOS kliniğine başvuran hastalar dahil edilmiştir. Anti-mullerain hormon (AMH) düzeyleri fenotip değerlendirmesine göre kaydedilmiştir. Bulgular: Çalışmaya toplam 118 PKOS hastası katılmıştır. Buna göre 47 hasta (%39.8) fenotip A, 15 hasta (%12.7) fenotip B, 37 hasta (%31.3) fenotip C ve 19 hasta (%16.1) fenotip D’dir. Hastaların yaş ortalaması 22.97±4.98 yıldır. Ortalama vücut kitle indeksi 26.1± 4.26 kg/m2’dir. PKOS polikliniğine en sık başvuru nedeni adet düzensizliğidir. Fenotip A (%80.9) ve fenotip D’de (%84.2) PKOS polikliniğine en sık başvuru nedeni adet düzensizliğidir. Polikistik over morfolojisi (PKOM) varlığı ve over disfonksiyonu sıklığının fenotipe göre dağılımında gruplar arasında fark vardır (p<0.001, p<0.001). Fenotipe göre ortanca AMH düzeyleri (ng/ml) arasında istatistiksel olarak anlamlı bir fark bulunmuştur (p<0.001). Ortanca değer fenotip A’da 6,3 ng/ml, fenotip B’de 2,4 ng/ml, grup C’de 6,1 ng/ml ve fenotip D’de 6,6 ng/ml’dir. Sonuç: Çalışmamızda fenotip A en sık gözlenen gruptur ve AMH düzeyleri fenotip D grubunda diğer gruplara göre anlamlı olarak daha yüksektir.

Abstract

Objective: The aim of this study was to investigate the level of antimullerian hormone in patients with polycystic ovary syndrome (PCOS) according to phenotypic characteristics. Materials and Methods: This study was designed as a cross-sectional cohort study and included patients attending the PCOS clinic of Etlik Zübeyde Hanım Gynecology Training and Research Hospital. Anti-mullerain hormone (AMH) levels were recorded according to phenotype assessment. Results: A total of 118 patients with PCOS participated in the study. Accordingly, 47 patients (39.8%) belonged to phenotype A, 15 patients (12.7%) to phenotype B, 37 patients (31.3%) to phenotype C and 19 patients (16.1%) to phenotype D. The mean age of the patients was 22.97±4.98 years. The mean body mass index was 26.1± 4.26 kg/m2. The most common reason for presentation to the PCOS outpatient clinic was irregular menstruation. The most common reason for presentation to the PCOS outpatient clinic was irregular menstruation in phenotype A (80.9%) and phenotype D (84.2%). There was a difference between the groups in the distribution of the presence of polycystic ovarian morphology (PCOM) and the frequency of ovarian dysfunction by phenotype (p<0.001, p<0.001). A statistically significant difference was found between median AMH levels (ng/ml) according to phenotype (p<0.001). The median value was 6.3 ng/ml in phenotype A, 2.4 ng/ml in phenotype B, 6.1 ng/ml in group C and 6.6 ng/ml in phenotype D. Conclusion: In our study, phenotype A was the most frequently observed group and AMH levels were significantly higher in the phenotype D group than in the other groups.

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Bu Makaleye Atıf Yap

Polat, S., Erginay, O. N. (2024). Polikistik Over Sendromu Fenotiplerine Göre Anti-Müllerian Hormon Değerleri. Türk Kadın Sağlığı ve Neonatoloji Dergisi, Volume: 6 Issue: 3. https://doi.org/10.46969/EZH.1482404

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