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Dergiler / Turkish Journal of Veterinary Research / 2026 / Volume: 9 Issue: 1

Effect of Agomelatine on Ischemic Damage in Experimental Head Trauma Model in Rats

Murat Kayabaş(KAFKAS UNIVERSITY)0000-0002-5768-2925
Mustafa Makav(KAFKAS ÜNİVERSİTESİ)0000-0003-1879-8180
Serdar Yiğit(KAFKAS UNIVERSITY)0000-0001-5631-2335
Levent Aras(KAFKAS UNIVERSITY)0000-0001-6175-0268
Levent Şahin(KAFKAS UNIVERSITY)0000-0003-0193-4393
Sayfa
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Yayın Tarihi
2025-03-28
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

In the histopathological analyses, a decrease in TUNEL-positive cells was observed in the HT-A group compared to that in the H group Conclusion: As a result, a decrease in both apoptotic cells and inflammatory responses was observed in the HT-A group.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Objective: This study aims to investigate the effect of agomelatine on ischemic injury in an experimentally created head trauma model in rats.
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Temel Bulgular & Veri:Materials and Methods: Groups: 1) control (C) incisions were made to the coronal and lambdoid sutures and a steel disc was placed without creating a controlled impact acceleration model; 2) head trauma (HT) did not receive any treatment after head trauma with a controlled impact acceleration model; 3) agomelatine (A) 20 mg/kg oral agomelatine given for 7 d after incisions were made to the coronal and lambdoid sutures and a steel disc was placed without creating a controlled impact acceleration model; 4) head trauma+agomelatine (HT-A) 20 mg/kg oral agomelatine given for 7 d after head trauma with a controlled impact acceleration model.
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Sonuç & Katkı:In the histopathological analyses, a decrease in TUNEL-positive cells was observed in the HT-A group compared to that in the H group Conclusion: As a result, a decrease in both apoptotic cells and inflammatory responses was observed in the HT-A group.
🔬Tür:Modelleme & Sayısal Simülasyon
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Head Trauma · TNF-α · IL-6

Abstract

Objective: This study aims to investigate the effect of agomelatine on ischemic injury in an experimentally created head trauma model in rats. Materials and Methods: Groups: 1) control (C) incisions were made to the coronal and lambdoid sutures and a steel disc was placed without creating a controlled impact acceleration model; 2) head trauma (HT) did not receive any treatment after head trauma with a controlled impact acceleration model; 3) agomelatine (A) 20 mg/kg oral agomelatine given for 7 d after incisions were made to the coronal and lambdoid sutures and a steel disc was placed without creating a controlled impact acceleration model; 4) head trauma+agomelatine (HT-A) 20 mg/kg oral agomelatine given for 7 d after head trauma with a controlled impact acceleration model. The rats were humanely euthanized after the study by ethical protocols, and blood and tissue samples were taken. Biochemical (tumor necrosis factor [TNF]-α and interleukin [IL]-6) and histopathological analyses (terminal deoxynucleotidyl transferase dUTP nick end labeling [TUNEL]) were conducted from these samples. Results: A significant difference was found in TNF-α between the HT and HT-A groups (p<0.05). There was a statistically significant increase in IL-6 in the HT group compared to that in the HT-A group (p<0.01). In the histopathological analyses, a decrease in TUNEL-positive cells was observed in the HT-A group compared to that in the H group Conclusion: As a result, a decrease in both apoptotic cells and inflammatory responses was observed in the HT-A group.

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Bu Makaleye Atıf Yap

Kayabaş, M., Makav, M., Yiğit, S., Aras, L., Şahin, L. (2025). Effect of Agomelatine on Ischemic Damage in Experimental Head Trauma Model in Rats. Turkish Journal of Veterinary Research, Volume: 9 Issue: 1. https://doi.org/10.47748/tjvr.1577903

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