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Dergiler / Turkish Journal of Veterinary Research / 2025 / Volume: 9 Issue: 2

The effect of intra articular application of adipose tissue-derived mesenchymal stem cells on the clinical complaints in two cats with osteochondrodysplasia

Yasin Parlatır(KIRIKKALE UNIVERSITY, FACULTY OF VETERINARY MEDICINE)0000-0002-6210-8979
Yalçın Alper Özturan(ADNAN MENDERES ÜNİVERSİTESİ, VETERİNER FAKÜLTESİ)0000-0003-0589-5686
İbrahim Süner0000-0003-4711-880X
Burak Antakyalıoğlu0000-0003-3544-291X
Mümin Alper Erdoğan(İZMİR KATİP ÇELEBİ ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0003-0048-444X
Sayfa
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Yayın Tarihi
2025-10-30
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Yapay Zeka Hızlı Bakış & Çıkarımlar

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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Further research is needed to explore its long-term efficacy and correlation with imaging outcomes.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Osteochondrodysplasia is a degenerative joint condition caused by a TRPV4 gene mutation, predominantly affecting Scottish Fold cats.
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Temel Bulgular & Veri:Case 1 involved a 3-year-old cat with a one-month history of lameness and joint degeneration, while Case 2 featured a 4-year-old cat with a five-month history of similar symptoms.
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Sonuç & Katkı:Further research is needed to explore its long-term efficacy and correlation with imaging outcomes.
🔬Tür:Case Report
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Osteochondrodisplazi · cat · stem cell

Abstract

Osteochondrodysplasia is a degenerative joint condition caused by a TRPV4 gene mutation, predominantly affecting Scottish Fold cats. This study evaluated the effects of adipose-derived mesenchymal stem cells (MSCs) in two Scottish Fold cats diagnosed with osteochondrodysplasia. Case 1 involved a 3-year-old cat with a one-month history of lameness and joint degeneration, while Case 2 featured a 4-year-old cat with a five-month history of similar symptoms. MSCs were isolated, characterized at passage 3, and administered intra-articularly at a dose of 1 × 10^6 cells/kg body weight. Both cats demonstrated significant clinical improvement, including resolution of lameness and increased mobility, despite persistent radiographic abnormalities. These findings suggest that MSC therapy may effectively alleviate clinical symptoms of osteochondrodysplasia. Further research is needed to explore its long-term efficacy and correlation with imaging outcomes.

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Bu Makaleye Atıf Yap

Parlatır, Y., Özturan, Y. A., Süner, İ., Antakyalıoğlu, B., Erdoğan, M. A. (2025). The effect of intra articular application of adipose tissue-derived mesenchymal stem cells on the clinical complaints in two cats with osteochondrodysplasia. Turkish Journal of Veterinary Research, Volume: 9 Issue: 2. https://doi.org/10.47748/tjvr.1616194

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