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Dergiler / The Eurasia Proceedings of Science Technology Engineering and Mathematics / 2026 / Issue: 2

Synthesis and Antioxidant Activities of Some Novel 1-(Morpholine-4-il-methyl)-3-alkyl(aryl)-4-(3-methoxy-4-isobutyryloxy)benzylideneamino-4,5-dihydro-1H-1,2,4-triazol-5-ones

Sevda Manap
Fevzi Aytemız
Haydar Yuksek
Sayfa
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Yayın Tarihi
2018-08-19
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

BHT, BHA, EDTA and α-tocopherol were used as reference antioxidant compounds.

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Amaç & Hipotez:In this study, 3-alkyl(aryl)-4-(3-methoxy-4-isobutyryloxy)benzylideneamino-4,5-dihydro-1H-1,2,4-triazol-5-ones (1) were treated with morpholine in the presence of formaldehyde according to the Mannich reaction to synthesize five novel 1-(morpholine-4-yl-methyl)-3-alkyl(aryl)-4-(3-methoxy-4-isobutyryloxy)benzylideneamino-4,5-dihydro-1 H -1,2,4-triazol-5-ones (2).
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Temel Bulgular & Veri:In addition, the antioxidant properties of compounds 2 were analyzed and evaluated using three antioxidant assays, including reducing power, free radical scavenging and metal chelating activity.
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Sonuç & Katkı:BHT, BHA, EDTA and α-tocopherol were used as reference antioxidant compounds.
🔬Tür:Research Article
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:4-Triazol-5-one · Mannich base · Antioxidant activity

Abstract

In this study, 3-alkyl(aryl)-4-(3-methoxy-4-isobutyryloxy)benzylideneamino-4,5-dihydro-1H-1,2,4-triazol-5-ones (1) were treated with morpholine in the presence of formaldehyde according to the Mannich reaction to synthesize five novel 1-(morpholine-4-yl-methyl)-3-alkyl(aryl)-4-(3-methoxy-4-isobutyryloxy)benzylideneamino-4,5-dihydro-1 H -1,2,4-triazol-5-ones (2). In addition, the antioxidant properties of compounds 2 were analyzed and evaluated using three antioxidant assays, including reducing power, free radical scavenging and metal chelating activity. For the measurement of the reductive ability, Fe 3+ -Fe 2+ transformation was investigated in the presence of compound using by the method of Oyaizu (1986). The hydrogen atoms or electrons donation ability of the synthesized compound was measured by DPPH . using the method of Blois (1958 ). The chelating effect of ferrous ions by the compound was determined according to the method of Dinis, Madeira & Almeida (1994 ). BHT, BHA, EDTA and α-tocopherol were used as reference antioxidant compounds.

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Bu Makaleye Atıf Yap

Manap, S., Aytemız, F., Yuksek, H. (2018). Synthesis and Antioxidant Activities of Some Novel 1-(Morpholine-4-il-methyl)-3-alkyl(aryl)-4-(3-methoxy-4-isobutyryloxy)benzylideneamino-4,5-dihydro-1H-1,2,4-triazol-5-ones. The Eurasia Proceedings of Science Technology Engineering and Mathematics, Issue: 2. https://ajindex.com/articles/1551576

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Kaynakça (14)

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