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Dergiler / Sabuncuoglu Serefeddin Health Sciences / 2026 / Cilt: 7 Sayı: 1

INVESTIGATION OF THE FREQUENCY OF MICROSATELLITE INSTABILITY FROM PATHOLOGICAL TISSUE SAMPLES OF PATIENTS WITH GASTRIC CANCER AND ITS EFFECT ON DISEASE PROGNOSIS AND TREATMENT

Husnu Serdar Kiziltunc(Eleşkirt State Hospital Department of Internal Medicine)
Salim Başol Tekin(Atatürk University, Department of Medical Oncology, Faculty of Medicine)0000-0002-0974-3412
Sayfa
17–21
Yayın Tarihi
2025-04-30
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

As a result, it was seen that microsatellite stability was a negative risk factor for mortality in gastric cancer, however, it was concluded that microsatellite instability should be evaluated together with other risk factors that may have an effect on the disease.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Gastric cancers continues to be one of the most important health problems in our society with high morbidity and mortality rates.
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Temel Bulgular & Veri:In our study, microsatellite instability results of the patients were seen as microsatellite stable (MSS) in 45 (90%) patients, microsatellite instability high (MSI-H) in 2 (4%) patients and microsatellite instability low (MSI-L) in 3 (6%) patients.
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Sonuç & Katkı:As a result, it was seen that microsatellite stability was a negative risk factor for mortality in gastric cancer, however, it was concluded that microsatellite instability should be evaluated together with other risk factors that may have an effect on the disease.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Gastric cancer · Microsatellite instability · Morbidity

Abstract

Gastric cancers continues to be one of the most important health problems in our society with high morbidity and mortality rates. Based on genomic characterization, gastric cancer has recently been defined as a heterogeneous disease consisting of different subtypes, each with unique molecular features and specific clinics. In this study, we tried to investigate the frequency of microsatellite instability in gastric cancers and its effects on the disease. In our study, microsatellite instability results of the patients were seen as microsatellite stable (MSS) in 45 (90%) patients, microsatellite instability high (MSI-H) in 2 (4%) patients and microsatellite instability low (MSI-L) in 3 (6%) patients. It was observed that microsatellite stability was an independent risk factor for mortality. (p=0.035). As a result, it was seen that microsatellite stability was a negative risk factor for mortality in gastric cancer, however, it was concluded that microsatellite instability should be evaluated together with other risk factors that may have an effect on the disease.

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Bu Makaleye Atıf Yap

Kiziltunc, H. S., Tekin, S. B. (2025). INVESTIGATION OF THE FREQUENCY OF MICROSATELLITE INSTABILITY FROM PATHOLOGICAL TISSUE SAMPLES OF PATIENTS WITH GASTRIC CANCER AND ITS EFFECT ON DISEASE PROGNOSIS AND TREATMENT. Sabuncuoglu Serefeddin Health Sciences, Cilt: 7 Sayı: 1, 17–21. https://doi.org/10.55895/sshs.1688217

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Kaynakça (9)

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  7. Al-Batran, S. E., Homann, N., Pauligk, C., Goetze, T. O., Meiler, J., Kasper, S.,. & Hofheinz, R. D. (2019). Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4): a randomised, phase 2/3 trial. The Lancet, 393(10184), 1948-1957. doi:10.1016/S0140-6736(18)32557-1
  8. Choi, Y. Y., Bae, J. M., An, J. Y., Kwon, I. G., Cho, I., Shin, H. B.,. & Noh, S. H. (2014). Is microsatellite instability a prognostic marker in gastric cancer?: A systematic review with meta‐analysis. Journal of surgical oncology, 110(2), 129-135. doi:10.1002/jso.23618
  9. Halling, K. C., Harper, J., Moskaluk, C. A., Thibodeau, S. N., Petroni, G. R., Yustein, A. S.,. & Powell, S. M. (1999). Origin of microsatellite instability in gastric cancer. The American journal of pathology, 155(1), 205-211. doi:10.1016/S0002-9440(10)65114-0