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Dergiler / Mehmet Akif Ersoy Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi / 2024 / Volume: 12 Issue: 3

Amantadine preserve VCAM immunoexpression levels in cardiac injury induced by brain trauma with its anti-inflammatory action and protective effect on the mitochondrial membrane

Özlem Özmen(BURDUR MEHMET AKİF ERSOY ÜNİVERSİTESİ)0000-0002-1835-1082
Halil Aşçı(SULEYMAN DEMIREL UNIVERSITY)0000-0002-1545-035X
Mehtap Savran(SULEYMAN DEMIREL UNIVERSITY)0000-0002-7933-0453
Melda Şahin(BURDUR MEHMET AKİF ERSOY UNIVERSITY)0000-0001-9207-6931
Hüseyin Dolu(Mehmet Akif Ersoy Üniversitesi)0009-0004-7524-2810
Sayfa
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Yayın Tarihi
2024-12-28
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Yapay Zeka Hızlı Bakış & Çıkarımlar

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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Further studies are needed to clarify underlying mechanisms.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Brain trauma-induced cytokine storms can impact multiple organs, particularly the heart, through inflammatory and apoptotic mechanisms.
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Temel Bulgular & Veri:Forty rats were divided into four groups: sham, BTCI, BTCI+AMN-1 (45 mg/kg, ip), and BTCI+AMN-7.
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Sonuç & Katkı:Further studies are needed to clarify underlying mechanisms.
🔬Tür:Research Article
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Brain trauma · heart · VCAM

Abstract

Brain trauma-induced cytokine storms can impact multiple organs, particularly the heart, through inflammatory and apoptotic mechanisms. This study aimed to examine cardiac pathology following experimental brain trauma (BTCI) and evaluate the protective effects of amantadine (AMN), an NMDA receptor antagonist, on cardiotoxicity. Forty rats were divided into four groups: sham, BTCI, BTCI+AMN-1 (45 mg/kg, ip), and BTCI+AMN-7. Trauma (0.2 Newton) was induced by dropping a 50 g ball from 80 cm. Heart samples were collected 24 hours and seven days post-trauma for histopathological and immunohistochemical analysis. The BTCI group showed hyperemia, hemorrhage, inflammatory infiltrations, increased Bax and VCAM expressions, and decreased Bcl-2 expression. AMN treatment reversed these findings, with greater efficacy observed after seven days. In conclusion, BTCI induces cardiac damage, while AMN provides protective effects. Further studies are needed to clarify underlying mechanisms.

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Bu Makaleye Atıf Yap

Özmen, Ö., Aşçı, H., Savran, M., Şahin, M., Dolu, H. (2024). Amantadine preserve VCAM immunoexpression levels in cardiac injury induced by brain trauma with its anti-inflammatory action and protective effect on the mitochondrial membrane. Mehmet Akif Ersoy Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, Volume: 12 Issue: 3. https://doi.org/10.24998/maeusabed.1593256

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