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Posttranskripsiyonel RNA modifikasyonları ve fonksiyonları

Posttranscriptional RNA modifications and functions

Zeliha Tuncer(KTO KARATAY ÜNİVERSİTESİ)0000-0001-8131-1422
Ercan Kurar(NECMETTİN ERBAKAN ÜNİVERSİTESİ)0000-0002-9234-1560
Sayfa
73–83
Yayın Tarihi
2021-08-30
DOI
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Yapay Zeka Hızlı Bakış & Çıkarımlar

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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

RNA'da posttranskripsiyonel modifikasyonları yeni bir alan olup biyolojik önemini anlamak için yeni çalışmalara ihtiyaç duyulmaktadır.

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Amaç & Hipotez:Transkripsiyon sonrası mRNA modifikasyonları, posttranskripsiyonel RNA modifikasyonları, RNA epigenetiği ya da epitranskriptomiks olarak adlandırılmaktadır.
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Temel Bulgular & Veri:RNA'da DNA’ya göre daha fazla modifikasyon olmaktadır, çünkü DNA genetik bilgi deposu iken RNA mRNA, rRNA, tRNA, miRNA gibi farklı türlerine ve farklı katalitik, gen düzenleme, protein sentezi gibi fonksiyonlara sahiptir.
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Sonuç & Katkı:RNA'da posttranskripsiyonel modifikasyonları yeni bir alan olup biyolojik önemini anlamak için yeni çalışmalara ihtiyaç duyulmaktadır.
🔬Tür:Derleme
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Epigenetik · RNA · 5-metilsitozin (m5C)

Özet

Transkripsiyon sonrası mRNA modifikasyonları, posttranskripsiyonel RNA modifikasyonları, RNA epigenetiği ya da epitranskriptomiks olarak adlandırılmaktadır. RNA'da DNA’ya göre daha fazla modifikasyon olmaktadır, çünkü DNA genetik bilgi deposu iken RNA mRNA, rRNA, tRNA, miRNA gibi farklı türlerine ve farklı katalitik, gen düzenleme, protein sentezi gibi fonksiyonlara sahiptir. RNA’da posttranskripsiyonel modifikasyonlar yaklaşık 60 yıl önce Psödoouridinin (Ψ) tanımlanması ile keşfedildi. RNA'larda gözlenen 3 majör modifikasyon, 2’-0-metil nükleotit, 5-metilsitozin (m5C) ve N6-metil adenindir (m6A). m6A modifikasyonunun embriyonik ve nöral kök hücrelerin farklılaşmasında önemli bir rol oynadığı bulunmuştur. RNA'da posttranskripsiyonel modifikasyonları yeni bir alan olup biyolojik önemini anlamak için yeni çalışmalara ihtiyaç duyulmaktadır.

Abstract

Post transcriptional mRNA modifications are called epitranscriptomics or RNA epigenetics. There are more modifications in RNA than DNA because the DNA is a genetic information store, while RNA has different types of mRNAs including mRNA, rRNA, tRNA, miRNA, and different catalytic, gene regulation, protein synthesis functions. Identification of pseudouridine (Ψ) was discovered about 60 years ago. Three major modifications observed in RNAs are 2’-O-methyl nucleotide, 5-methylcytosine (m5C) and N6-methyl adenosine. m6A modification has been found to play an important role in the differentiation of embryonic stem cells and nerve cell. RNA epigenetics studies are a very new area and require many more studies to understand its biological significance.

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Bu Makaleye Atıf Yap

Tuncer, Z., Kurar, E. (2021). Posttranskripsiyonel RNA modifikasyonları ve fonksiyonları. KTO Karatay Üniversitesi Sağlık Bilimleri Dergisi, Cilt: 2 Sayı: 2, 73–83. https://ajindex.com/articles/1523470

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