Comparison of Viral Agents and Vitamin D Levels in Children with Acute Bronchiolitis Infection

Özet

Objective: The aim of this study was to determine the vitamin D level and prognostic relationship with viral agents causing acute bronchiolitis.Material and Methods: Files of the patients who were hospitalized with the diagnosis of acute bronchiolitis in the pediatric service and intensive care unit of Ankara Training and Research Hospital were reviewed retrospectively. Patients were classified as mild, moderate or severe according to clinical evaluation. Serum 25 (OH) vitamin D levels were classified as 30 ng/mL normal.Results: Median age of 130 patients was 8 months (1-108) and 60.8% were male. 69.2% of the patients were the citizens of the Republic of Turkey while 30.8% were refugees. 28.5% of the patients had mild, 30% had mod-erate, and 41.5% had severe scores. High flow oxygen therapy was applied to 56.9% of the patients and oseltamivir treatment was given to 50.8% of the patients. 26.9% of the patients were observed in intensive care and 3.8% were observed in mechanical ventilator. Respiratory syncytial virus was detected in 55.3% of nasopharyngeal swab specimens. Vitamin D defi-ciency was found in 36.9% and vitamin D insufficiency was found in 33.8% of the patients. Male patients who were citizens of the Republic of Turkey and who were given prophylactic vitamin D had significantly higher 25 (OH) vitamin D levels than other groups (p< 0.05). 25 (OH) vitamin D levels were found to be 21.9 ng/mL in patients with respiratory syncytial virus infection and 24.2 ng/mL in other viral swab samples (p= 0.058). Vitamin D levels were below normal in 70.3% of high-flow oxygen therapy patients and 71.2% of patients receiving oseltamivir treatment.Conclusion: Although there was no relationship between vitamin D levels and viral agents, 25 (OH) vitamin D levels of patients with severe bronchiolitis, intensive care unit patients, and high flow oxygen therapy patients were found to be below normal. We think that 25 (OH) D vitamin levels should be considered in children with acute bronchiolitis clinic and vitamin D treatment can be useful.