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Dergiler / Journal of Surgery and Medicine / 2026 / Cilt: 5 Sayı: 10

Serum galectin-3 levels and vitamin D relationship in heart failure

Mustafa Özcan(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İSTANBUL PROF. DR. CEMİL TAŞÇIOĞLU ŞEHİR SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ)0000-0002-5613-0336
Murat Akarsu(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İSTANBUL KANUNİ SULTAN SÜLEYMAN SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ)0000-0002-2675-4252
Şengül Aydın Yoldemir(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İSTANBUL BAKIRKÖY DR. SADİ KONUK SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ)0000-0003-4236-1181
Özgür Altun(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İSTANBUL PROF. DR. CEMİL TAŞÇIOĞLU ŞEHİR SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ)0000-0003-1810-7490
Orkide Kutlu(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İSTANBUL PROF. DR. CEMİL TAŞÇIOĞLU ŞEHİR SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ)0000-0002-4402-2231
Semih Kalyon(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İSTANBUL PROF. DR. CEMİL TAŞÇIOĞLU ŞEHİR SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ)0000-0003-4207-0800
Gülden Yürüyen
Perihan Özkan Gümüşkaya(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İSTANBUL OKMEYDANI SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ)0000-0002-0838-9220
Neslihan Özsoy(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İSTANBUL PROF. DR. CEMİL TAŞÇIOĞLU ŞEHİR SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ)0000-0001-8660-1648
Hasan Eruzun(ONDOKUZ MAYIS ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0003-0355-1820
Yücel Arman(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İSTANBUL PROF. DR. CEMİL TAŞÇIOĞLU ŞEHİR SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ)0000-0002-9584-6644
Tufan Tükek(İSTANBUL ÜNİVERSİTESİ, İSTANBUL TIP FAKÜLTESİ)0000-0002-4237-1163
Sayfa
1046–1049
Yayın Tarihi
2021-10-01
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Yapay Zeka Hızlı Bakış & Çıkarımlar

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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

We think that both molecules are important prognostic biomarkers in cardiac inflammation and fibrosis.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Background/Aim: Heart failure is an important health problem with an increasing incidence in the world and poor prognosis.
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Temel Bulgular & Veri:Galectin-3 is associated with progressive fibrosis, an underlying pathology of heart failure, just as vitamin D deficiency.
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Sonuç & Katkı:We think that both molecules are important prognostic biomarkers in cardiac inflammation and fibrosis.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Galectin 3 · Congestive heart failure · Vitamin D3 level

Abstract

Background/Aim: Heart failure is an important health problem with an increasing incidence in the world and poor prognosis. Galectin-3 is associated with progressive fibrosis, an underlying pathology of heart failure, just as vitamin D deficiency. We examined the relationship between the stage of heart failure and galectin-3 and 25-OH vitamin D levels. Methods: Sixty patients with heart failure and 30 healthy volunteers were included in this prospective case-control study. Demographic data, comorbid diseases and laboratory data were examined, and 25-OH vitamin D and galectin-3 levels were compared between the patients with CHF and the control group. Results: Galectin-3 levels were high in patients with heart failure (P<0.001) and increased as the ejection fraction (EF) decreased (P=0.001). 25-OH vitamin D levels were lower in the patient group compared to the control group (P<0.001). There was no significant correlation between serum galectin-3 and vitamin D levels (r=-0.22; P=0.094); however, serum galectin-3 levels and the stage of CHF were correlated (r=0.66; P=0.001). Conclusions: We found high serum galectin-3 levels in patients with heart failure and low 25 OH vitamin D levels. We think that both molecules are important prognostic biomarkers in cardiac inflammation and fibrosis.

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Bu Makaleye Atıf Yap

Özcan, M., Akarsu, M., Yoldemir, Ş. A., Altun, Ö., Kutlu, O., Kalyon, S., Yürüyen, G., Gümüşkaya, P. Ö., Özsoy, N., Eruzun, H., Arman, Y., Tükek, T. (2021). Serum galectin-3 levels and vitamin D relationship in heart failure. Journal of Surgery and Medicine, Cilt: 5 Sayı: 10, 1046–1049. https://doi.org/10.28982/josam.1003992

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