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Dergiler / Journal of Surgery and Medicine / 2026 / Cilt: 6 Sayı: 2

Evaluation of LIPI and mGPS as prognostic factors in extensive-stage small-cell lung cancer

Abdilkerim Oyman(UNIVERSITY OF HEALTH SCIENCES, İSTANBUL ÜMRANİYE HEALTH RESEARCH CENTER)0000-0002-2291-7544
Ibrahim Cil(UNIVERSITY OF HEALTH SCIENCES, İSTANBUL ÜMRANİYE HEALTH RESEARCH CENTER)0000-0002-6388-0346
Melike Özçelik(UNIVERSITY OF HEALTH SCIENCES, İSTANBUL ÜMRANİYE HEALTH RESEARCH CENTER)0000-0003-0406-715X
Deniz Tataroğlu Özyükseler(UNIVERSITY OF HEALTH SCIENCES, İSTANBUL KARTAL DR. LÜTFİ KIRDAR HEALTH RESEARCH CENTER)0000-0002-0254-1084
Mustafa Başak(TOKAT GAZIOSMANPASA UNIVERSITY, SCHOOL OF MEDICINE)0000-0003-1329-774X
Ali Gökyer(TRAKYA UNIVERSITY, TRAKYA RESEARCH AND APPLICATION CENTER)0000-0002-1653-6155
İlker Nihat Ökten(ISTANBUL MEDENIYET UNIVERSITY, FACULTY OF HEALTH SCIENCES)0000-0003-2360-3392
Sayfa
115–119
Yayın Tarihi
2022-02-01
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

It would be better to consider the use of the LIPI score when managing extensive-stage small cell lung cancer.

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Amaç & Hipotez:Background/Aim: There is an unmet need for effective prognostic models in small cell lung cancer.
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Temel Bulgular & Veri:Methods: Patients who were 18 years of age or older, diagnosed with extensive-stage small cell lung carcinoma who received platinum-based chemotherapy as first-line treatment were included in this retrospective observational study.
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Sonuç & Katkı:It would be better to consider the use of the LIPI score when managing extensive-stage small cell lung cancer.
🔬Tür:Modelleme & Sayısal Simülasyon
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Lung immune index · Small cell · Prognostic factor

Abstract

Background/Aim: There is an unmet need for effective prognostic models in small cell lung cancer. Lung immune prognostic index (LIPI) and Modified Glasgow Prognostic Score (mGPS) markers are prognostic in various cancers. We aimed to examine LIPI and GPS markers' prognostic effects on overall survival (OS) in extensive-stage small-cell lung cancer (SCLC) patients. Methods: Patients who were 18 years of age or older, diagnosed with extensive-stage small cell lung carcinoma who received platinum-based chemotherapy as first-line treatment were included in this retrospective observational study. Having concurrent or sequential radiotherapy to the thorax and receiving non-platinum-based chemotherapy as first-line treatment were the criteria for exclusion. We measured their pretreatment LIPI and mGPS markers and performed multivariate Cox regression analyses of progression-free survival (PFS) or OS in extensive stage-SCLC patients. Results: A total of 129 patients were included in the study. Twenty-eight patients (21.7%) were mGPS 0, 65 patients (50.4%) were mGPS 1, and 36 (27.9%) were mGPS 2. Fourteen percent of the patients were LIPI 0 (n=18), %38 were LIPI 1 (n=49), and %48 were LIPI 2 (n=62). The OS of the mGPS 0, mGPS 1, and mGPS 2 patients were 19.0 months (95% CI, 16.3-21.7), 8.4 months (95% CI, 7.1-9.8), and 6.4 months (95% CI, 3.1-9.6) respectively, and those of LIPI 0, LIPI 1, and LIPI 2 patients were 18.3 months (95% CI, 9.9-26.7), 11.7 months (95% CI, 5.3-18.1), and eight months (95% CI, 6.6-9.5), respectively. In the multivariate analysis, ECOG PS 0-1 and LIPI score 0-1 were associated with better PFS (P=0.035 and P=0.03 respectively) and OS (P=0.003 and P=0.036 respectively). Conclusions: LIPI score predicted an unfavorable prognosis, whereas mGPS was not associated with survival. It would be better to consider the use of the LIPI score when managing extensive-stage small cell lung cancer.

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Bu Makaleye Atıf Yap

Oyman, A., Cil, I., Özçelik, M., Özyükseler, D. T., Başak, M., Gökyer, A., Ökten, İ. N. (2022). Evaluation of LIPI and mGPS as prognostic factors in extensive-stage small-cell lung cancer. Journal of Surgery and Medicine, Cilt: 6 Sayı: 2, 115–119. https://doi.org/10.28982/josam.990665

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Kaynakça (16)

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