This novel study aims to report a rare case of IgG4-related MD complicated with severe autoimmune thrombocytopenia without any hematological malignancies and review all cases of IgG4-related disease associated with thrombocytopenia in the literature.
📌 3 Maddede Bu Makale
🎯
Amaç & Hipotez:Mikulicz’s disease (MD), an immunoglobulin G4 (IgG4)-related disease, is a fibrosis-associated inflammatory disease characterized by painless bilateral swelling of lacrimal and salivary glands.
📊
Temel Bulgular & Veri:Although thrombocytopenia is associated with many rheumatologic disorders, it is rare in IgG4-related MD.
💡
Sonuç & Katkı:This novel study aims to report a rare case of IgG4-related MD complicated with severe autoimmune thrombocytopenia without any hematological malignancies and review all cases of IgG4-related disease associated with thrombocytopenia in the literature.
🔬Tür:Literatür & Derleme Çalışması
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri
Özet
Mikulicz’s disease (MD), an immunoglobulin G4 (IgG4)-related disease, is a fibrosis-associated inflammatory disease characterized by painless bilateral swelling of lacrimal and salivary glands. Although thrombocytopenia is associated with many rheumatologic disorders, it is rare in IgG4-related MD. This novel study aims to report a rare case of IgG4-related MD complicated with severe autoimmune thrombocytopenia without any hematological malignancies and review all cases of IgG4-related disease associated with thrombocytopenia in the literature.
🔖
Bu Makaleye Atıf Yap
LI, S., DENG, C., CHEN, J., LI, F. (2019). Mikulicz’s Disease With Immune Thrombocytopenia: A New Immunoglobulin G4-Mediated Disorder and Literature Review. art, Cilt: 34 - Sayı: 3, 343–347. https://ajindex.com/articles/151205
Kamisawa T, Zen Y, Pillai S, Stone JH. IgG4-related disease. Lancet 2015;385:1460-71
Himi T, Takano K, Yamamoto M, Naishiro Y, Takahashi H. A novel concept of Mikulicz’s disease as IgG4- related disease. Auris Nasus Larynx 2012;39:9-17
Sakurai C, Ohashi K, Sakaguchi K, Hishima T, Kamata N, Akiyama H, et al. Mikulicz’s disease with severe thrombocytopenia following autologous stem cell transplantation in a multiple myeloma patient. Int J Hematol 2009;90:532-6
Takahashi H, Yamamoto M, Tabeya T, Suzuki C, Naishiro Y, Shinomura Y, et al. The immunobiology and clinical characteristics of IgG4 related diseases. J Autoimmun 2012;39:93-6
Stone JH, Khosroshahi A, Deshpande V, Chan JK, Heathcote JG, Aalberse R, et al. Recommendations for the nomenclature of IgG4-related disease and its individual organ system manifestations. Arthritis Rheum 2012;64:3061-7
Yao Q, Wu G, Hoschar A. IgG4-related Mikulicz’s disease is a multiorgan lymphoproliferative disease distinct from Sjögren's syndrome: a Caucasian patient and literature review. Clin Exp Rheumatol 2013;31:289-94
Fragoulis GE, Zampeli E, Moutsopoulos HM. IgG4- related sialadenitis and Sjögren’s syndrome. Oral Dis 2017;23:152-6
Avincsal MO, Zen Y. The Histopathology of IgG4- Related Disease. Curr Top Microbiol Immunol 2017;401:45-60
Choung BS, Yoo WH. Successful treatment with intravenous immunoglobulin of severe thrombocytopenia complicated in primary Sjögren’s syndrome. Rheumatol Int 2012;32:1353-5
Takasumi M, Miyata M, Kuroda M, Terashima K, Abe K, Takahashi A, et al. Overlap of IgG4-related Disease and Primary Biliary Cirrhosis Complicated with Autoimmune Thrombocytopenia. Intern Med 2016;55:1387-92
Huh HJ, Park CJ, Kim SW, Han SH, Jang S, Chi HS. Flow cytometric detection of plateletassociated immunoglobulin in patients with immune thrombocytopenic purpura and nonimmune thrombocytopenia. Ann Clin Lab Sci 2009;39:283-8
Teeling JL, Jansen-Hendriks T, Kuijpers TW, de Haas M, van de Winkel JG, Hack CE, et al. Therapeutic efficacy of intravenous immunoglobulin preparations depends on the immunoglobulin G dimers: studies in experimental immune thrombocytopenia. Blood 2001;98:1095-9
Nakamura A, Funatomi H, Katagiri A, Katayose K, Kitamura K, Seki T, et al. A case of autoimmune pancreatitis complicated with immune thrombocytopenia during maintenance therapy with prednisolone. Dig Dis Sci 2003;48:1968-71
Shimazu Y, Uchiyama T, Mizumoto C, Takeoka T, Tsuji M, Tomo