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Dergiler / Journal of Ongoing Chemical Research / 2017 / Volume: 3 Issue: 1

SYNTHESIS, CHARACTERIZATION, UREASE INHIBITORY AND TYROSINASE INHIBITORY ACTIVITIES OF SOME CHIRAL PYRAZOLO DERIVATIVES

Yusuf Sıcak(Department of Aromatic and Medicinal Plants, Köyceyiz Vocational School, Muğla Sıtkı Koçman University, Köyceğiz-48800, MUĞLA Turkey)
Said Nadeem(Department of Chemistry, Faculty of Sciences, Muğla Sıtkı Koçman University, Kötekli-48121 MUĞLA Turkey)
Bedriye Seda Kurşun Aktar(Department of Property Protection and Security, Yapraklı Vocational School, Çankırı Karatekin University, 18200 ÇANKIRI Turkey)
Emine Elçin Oruç Emre(Department of Chemistry, Faculty of Art and Sciences, Gaziantep University, Şehitkamil-27310 GAZİANTEP Turkey)
Mehmet Öztürk(Department of Chemistry, Faculty of Sciences, Muğla Sıtkı Koçman University, Kötekli-48121 MUĞLA Turkey)
Ayşegül Karaküçük İyidoğan(Department of Chemistry, Faculty of Art and Sciences, Gaziantep University, Şehitkamil-27310 GAZİANTEP Turkey)
Mehmet Ali Özler(Department of Chemistry, Faculty of Sciences, Muğla Sıtkı Koçman University, Kötekli-48121 MUĞLA Turkey)
İbrahim Demirtaş(Department of Chemistry, Faculty of Sciences, Çankırı Karatekin University, 18200 ÇANKIRI Turkey)
Sayfa
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Yayın Tarihi
2017-06-01
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Yapay Zeka Hızlı Bakış & Çıkarımlar

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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

According to tyrosinase assay results, compound 2f showed the good tyrosinase inhibitory activity i.e. 6.12±0.40 mM of IC50

📌 3 Maddede Bu Makale

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Amaç & Hipotez:A series of some pyrazolo derivatives a-f were synthesized and their urease inhibitory and tyrosinase inhibitory activities were evaluated.
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Temel Bulgular & Veri:Among synthesized compounds, 2f, 2e, 1f, 2d, 1e, 2b, and 1d showed excellent activities IC50 i.e. 11.73±0.28, 14.21±0.56, 15.37±0.89, 17.66±0.82, 18.64±0.19, 19.55±0.39, and 22.08±0.96 µM, respectively.
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Sonuç & Katkı:According to tyrosinase assay results, compound 2f showed the good tyrosinase inhibitory activity i.e. 6.12±0.40 mM of IC50
🔬Tür:Research Article
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Pyrrolidine · chiral · thiazolidine-2

Abstract

A series of some pyrazolo derivatives a-f were synthesized and their urease inhibitory and tyrosinase inhibitory activities were evaluated. Among synthesized compounds, 2f, 2e, 1f, 2d, 1e, 2b, and 1d showed excellent activities IC50 i.e. 11.73±0.28, 14.21±0.56, 15.37±0.89, 17.66±0.82, 18.64±0.19, 19.55±0.39, and 22.08±0.96 µM, respectively. According to tyrosinase assay results, compound 2f showed the good tyrosinase inhibitory activity i.e. 6.12±0.40 mM of IC50

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Bu Makaleye Atıf Yap

Sıcak, Y., Nadeem, S., Aktar, B. S. K., Emre, E. E. O., Öztürk, M., İyidoğan, A. K., Özler, M. A., Demirtaş, İ. (2017). SYNTHESIS, CHARACTERIZATION, UREASE INHIBITORY AND TYROSINASE INHIBITORY ACTIVITIES OF SOME CHIRAL PYRAZOLO DERIVATIVES. Journal of Ongoing Chemical Research, Volume: 3 Issue: 1. https://doi.org/10.5281/zenodo.3768580

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