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Dergiler / Journal of Medicine and Palliative Care / 2026 / Volume: 4 Issue: 2

COVID-19'un uzun dönem mortalitesinde C-reaktif protein/ albümin oranı ve sistemik immün inflamasyon indeksinin prediktif değeri

Predictive value of c-reactive protein to albumin ratio and systemic immune-inflammation index for the long-term mortality in COVID-19

Esra Polat(Dr.Ersin Arslan Education and Research Hospital)0000-0002-2330-2816
Cengiz Şabanoğlu(Kırıkkale Yuksek Ihtisas Hospital)0000-0003-1163-5610
Muhdedir Caner(Kırıkkale Yuksek Ihtisas Hospital)0000-0002-2298-0287
Fatma Yekta Urkmez(Kırıkkale Yuksek Ihtisas Hospital)0000-0002-5438-4623
Fulden Akyüz İnanç(KIRIKKALE UNIVERSITY)0000-0002-2327-3349
Ünal Öztürk(Kahramanmaras Sutcu Imam University)0000-0001-8461-5595
Hüseyin Kandemir(Kırıkkale Yuksek Ihtisas Hospital)0000-0002-4462-7425
Gamze Yeter Arslan(Kepez State Hospital)0000-0002-0114-7448
Elif İlkay Yüce(Dr.Ersin Arslan Education and Research Hospital)0000-0001-9078-0941
İbrahim Halil İnanç(Kırıkkale Yuksek Ihtisas Hospital)0000-0003-4046-6748
Sayfa
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Yayın Tarihi
2023-03-27
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Bulgular: Çalışmaya 449 (53.6 %) erkek ve 389 ( 46.4 %) kadın katıldı.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Amaç: Coronavirüs-19 hastalığının (COVID-19) kısa dönem prognozu ile biyobelirteçlerle ilgili bir çok çalışma yapılmıştır; ancak uzun dönem prognozu ile ilgili çalışmalar kısıtlıdır.
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Temel Bulgular & Veri:Amacımız; sistemik inflamasyon indeksi (SII) ve C-reaktif protein/ albümin oranının (CAR) COVID-19 hastalığının hastane içi ve 1 yıllık takiplerinde prediktif değerini saptamaktır.
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Sonuç & Katkı:Bulgular: Çalışmaya 449 (53.6 %) erkek ve 389 ( 46.4 %) kadın katıldı.
🔬Tür:Research Article
📍Kapsam:19 hasta
⚙️Değişkenler:Systemic immune-inflammation index · SII · C-reactive protein to albumin ratio

Özet

Amaç: Coronavirüs-19 hastalığının (COVID-19) kısa dönem prognozu ile biyobelirteçlerle ilgili bir çok çalışma yapılmıştır; ancak uzun dönem prognozu ile ilgili çalışmalar kısıtlıdır. Amacımız; sistemik inflamasyon indeksi (SII) ve C-reaktif protein/ albümin oranının (CAR) COVID-19 hastalığının hastane içi ve 1 yıllık takiplerinde prediktif değerini saptamaktır. Gereç ve Yöntemler: Primer sonuçlar hastane içi mortalite ve 1 yıllık mortalite idi. İkincil sonuçlar; yatışta yoğun bakım ünitesi (YBÜ) ihtiyacı ve sonrasında YBÜ'ye transfer olma durumu idi. Bulgular: Çalışmaya 449 (53.6 %) erkek ve 389 ( 46.4 %) kadın katıldı. Yaş ortalaması 53.8±18.5 idi. Önceden bilinen kalp yetmezliği (KY), COVID-19 ile ilişkili KY, akut böbrek yetmezliği (ABY), diyabetes mellitus (DM), hipertansiyon (HT), koroner arter hastalığı (KAH), kronik obstrüktif akciğer hastalığı (KOAH)/astım , yüksek CO-RADS skoru ( >4), düşük Ejeksiyon Fraksiyonu (EF), yüksek CAR ve SII, artmış hastane içi ve 1 yıllık mortalite ile ilişkilendirildi (p < 0.05). Çok değişkenli analiz sonucunda; CAR, SII, ABY ve DM hastane içi ve 1 yıllık mortalitenin bağımsız belirteçleri iken, KAH sadece 1 yıllık mortalitenin bağımsız bir öngörücüsüydü. ROC analizi ile sırasıyla 2.54 ve 2.23 CAR değerleri, hastane içi ve 1 yıllık mortaliteyi predikte etti (p <0.001). Sırasıyla 1274 ve 1191 SII değerleri, hastane içi ve 1 yıllık mortaliteyi predikte etti (p <0.001). Sonuç: CAR ve SII, COVID-19’da hem kısa dönemde hem uzun dönemde mortaliteyi tahmin etmek için değerli prognostik indeksler olarak kullanılabilir.

Abstract

Aim: Several studies have investigated the association between biomarkers and short-term prognosis in the coronavirus infectious disease 2019 (COVID-19). However, data on the long-term prognosis are limited. To determine the predictive value of systemic immune-inflammation index (SII) and C-reactive protein (CRP) to albumin ratio (CAR) for in-hospital and 1-year outcomes during COVID-19. Material and Method: The primary outcomes were in-hospital and 1-year mortality. The secondary outcomes were the intensive care unit (ICU) need at admission and transfer to the ICU later on. Results: The study included 449 (53.6%) males and 389 (46.4%) females with a mean age of 53.8±18.5 years. Previously known heart failure (HF), COVID-19-related HF, acute renal failure (ARF), diabetes mellitus, hypertension, coronary artery disease (CAD), chronic obstructive pulmonary disease (COPD)/asthma, high CO-RADS scores (>4), low ejection fraction (EF), higher CAR and SII were associated with an increased in-hospital and 1-year mortality (p<0.05). After multivariate analysis; CAR, SII, ARF, and diabetes mellitus were independent predictors of in-hospital and 1-year mortality,whereas CAD was only an independent predictor of 1-year mortality. After ROC analysis, CAR cut-off levels of 2.54 and 2.23 predicted in-hospital and 1-year mortality, respectively (p<0.001). The SII cut-off levels of 1274 and 1191 predicted in-hospital and 1-year mortality, respectively (p<0.001). Conclusion: CAR and SII can be used as valuable prognostic indexes to predict both the short-term and long-term mortality in COVID-19.

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Bu Makaleye Atıf Yap

Polat, E., Şabanoğlu, C., Caner, M., Urkmez, F. Y., İnanç, F. A., Öztürk, Ü., Kandemir, H., Arslan, G. Y., Yüce, E. İ., İnanç, İ. H. (2023). COVID-19'un uzun dönem mortalitesinde C-reaktif protein/ albümin oranı ve sistemik immün inflamasyon indeksinin prediktif değeri. Journal of Medicine and Palliative Care, Volume: 4 Issue: 2. https://doi.org/10.47582/jompac.1256098

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