KaydedilenlerDerginizi ekleyin

Dergiler / Journal of Medicine and Palliative Care / 2026 / Volume: 6 Issue: 5

Hematolojik malignite hastalarında hiperbarik oksijen tedavisinin klinik seyri ve güvenliği: retrospektif bir analiz

Clinical course and safety of hyperbaric oxygen therapy in patients with hematologic malignancies: a retrospective analysis

Kübra Canarslan Demir(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, GÜLHANE TIP FAKÜLTESİ, GÜLHANE TIP PR. (ANKARA))0000-0001-6911-2375
Ahmet Uğur Avcı(UNIVERSITY OF HEALTH SCIENCES, GÜLHANE SCHOOL OF MEDICINE, GÜLHANE MEDICINE PR. (ANKARA))0000-0001-7776-3717
Kübra Özgök Kangal(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, GÜLHANE TIP FAKÜLTESİ, GÜLHANE TIP PR. (ANKARA))0000-0002-2449-4821
Berrin Ceylan(UNIVERSITY OF HEALTH SCIENCES, GÜLHANE SCHOOL OF MEDICINE, GÜLHANE MEDICINE PR. (ANKARA))0000-0003-4377-6856
Selcen Yüsra Abaylı(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, GÜLHANE TIP FAKÜLTESİ, GÜLHANE TIP PR. (ANKARA))0000-0002-0102-056X
Kerim Bora Yılmaz(UNIVERSITY OF HEALTH SCIENCES, GÜLHANE SCHOOL OF MEDICINE, GÜLHANE MEDICINE PR. (ANKARA))0000-0002-5514-4103
Sayfa
—
Yayın Tarihi
2025-10-24
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Bulgular: HBOT endikasyonları arasında AVN (%35), hemorajik sistit (%30) ve yara iyileşmesinde bozulma (%25) yer aldı.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:Amaç: Yoğun tedavi alan hematolojik maligniteli hastalarda hemorajik sistit, avasküler nekroz (AVN) ve yara iyileşmesinde bozulma gibi tedaviye bağlı komplikasyon riski yüksektir.
📊
Temel Bulgular & Veri:Bu çalışma, bu kırılgan hasta grubunda destekleyici bir tedavi seçeneği olarak hiperbarik oksijen tedavisinin (HBOT) güvenliğini ve klinik etkinliğini değerlendirmeyi amaçlamaktadır.
💡
Sonuç & Katkı:Bulgular: HBOT endikasyonları arasında AVN (%35), hemorajik sistit (%30) ve yara iyileşmesinde bozulma (%25) yer aldı.
🔬Tür:Research Article
📍Kapsam:2017–2023 · 20 hasta
⚙️Değişkenler:Hyperbaric oxygenation · hematologic neoplasms · supportive care

Özet

Amaç: Yoğun tedavi alan hematolojik maligniteli hastalarda hemorajik sistit, avasküler nekroz (AVN) ve yara iyileşmesinde bozulma gibi tedaviye bağlı komplikasyon riski yüksektir. Bu çalışma, bu kırılgan hasta grubunda destekleyici bir tedavi seçeneği olarak hiperbarik oksijen tedavisinin (HBOT) güvenliğini ve klinik etkinliğini değerlendirmeyi amaçlamaktadır. Yöntem: Bu retrospektif kohort çalışmada, 2017–2023 yılları arasında üçüncü basamak bir hiperbarik tıp merkezinde HBOT uygulanan hematolojik maligniteli 20 hasta değerlendirildi. Demografik veriler, HBOT endikasyonları, komplikasyonlar, klinik sonuçlar ve mortalite analiz edildi. HBOT, monoplace veya multiplace odalarda 2.4 ATA basınçta uygulandı. Bulgular: HBOT endikasyonları arasında AVN (%35), hemorajik sistit (%30) ve yara iyileşmesinde bozulma (%25) yer aldı. Medyan takip süresi 595 gündü. HBOT’ye bağlı ciddi bir komplikasyon gözlenmedi; yalnızca bir hafif barotravma vakası bildirildi. HBOT seans sayısı ile mortalite veya nüks arasında istatistiksel olarak anlamlı bir ilişki saptanmadı. Hemorajik sistit ve yara iyileşme sorunları olan hastaların çoğunda klinik iyileşme gözlendi. Sonuç: HBOT, özellikle sıkı enfeksiyon kontrol önlemleri altında uygulandığında, hematolojik maligniteli hastalarda uygulanabilir ve iyi tolere edilen bir destek tedavisi gibi görünmektedir. Bu bulgular, bu hassas hasta grubunda HBOT’nin güvenliği ve etkinliğini doğrulamak amacıyla ileriye dönük çalışmalara ihtiyaç olduğunu göstermektedir.

Abstract

Aims: Given the high risk of treatment-related complications such as hemorrhagic cystitis (HC), avascular necrosis (AVN), and impaired wound healing in patients with hematologic malignancies undergoing intensive therapies, this study aims to evaluate the safety and clinical effectiveness of hyperbaric oxygen therapy (HBOT) as a supportive treatment modality in this vulnerable patient population. Methods: This retrospective cohort study evaluated 20 patients with hematologic malignancies who received HBOT at a tertiary hyperbaric medicine center between 2017 and 2023. Demographic data, HBOT indications, complications, outcomes, and mortality were analyzed. HBOT was administered at 2.4 ATA in either monoplace or multiplace chambers. Results: HBOT indications included AVN (35%), HC (30%), impaired wound healing (25%), sudden sensorineural hearing loss (5%), and central retinal artery occlusion (5%). Median follow-up was 595 days. No serious HBOT-related complications were reported except for a single case of mild barotrauma. No statistically significant association was found between the number of HBOT sessions and mortality or recurrence. Improvements in clinical outcomes were observed in most patients with HC and wound healing problems. Conclusion: HBOT appears to be a feasible and well-tolerated supportive treatment in patients with hematologic malignancies, particularly when administered under strict infection control measures. These findings support further prospective studies to validate its safety and efficacy in this vulnerable population.

🔖

Bu Makaleye Atıf Yap

Demir, K. C., Avcı, A. U., Kangal, K. Ö., Ceylan, B., Abaylı, S. Y., Yılmaz, K. B. (2025). Hematolojik malignite hastalarında hiperbarik oksijen tedavisinin klinik seyri ve güvenliği: retrospektif bir analiz. Journal of Medicine and Palliative Care, Volume: 6 Issue: 5. https://doi.org/10.47582/jompac.1758111

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (44)

  1. Assessment UENC for E. SEER cancer statistics review, 1975-2005. March 15, 2009. Accessed April 3, 2025. https://hero.epa.gov/hero/index.cfm/reference/details/reference_id/730406
  2. Editors AS. SEER cancer statistics review, 1975-2007. http://seer.cancer.gov/csr/1975_2007/results_merged/sect_13_leukemia.pdf. Published online 2009. Accessed April 3, 2025. https://cir.nii.ac.jp/crid/ 1572261550705773184
  3. Jairam V, Lee V, Park HS, et al. Treatment-related complications of systemic therapy and radiotherapy. JAMA Oncol. 2019;5(7):1028-1035. doi:10.1001/jamaoncol.2019.0086
  4. Bernbeck B, Christaras A, Krauth K, et al. Bone marrow oedema and aseptic osteonecrosis in children and adolescents with acute lymphoblastic leukaemia or non-Hodgkin-lymphoma treated with hyperbaric-oxygen-therapy (HBO): an approach to cure?--BME/AON and hyperbaric oxygen therapy as a treatment modality. Klin Padiatr. 2004;216(6):370-378. doi:10.1055/s-2004-832341
  5. Ozturk H, Mirasoglu B, Aktas S. Hyperbaric oxygen treatment for refractory haemorrhagic cystitis occurring after chemotherapy and haematopoietic stem cell transplantation: retrospective analysis of 25 patients. Diving Hyperb Med. 2022;52(1):27-34. doi:10.28920/dhm52.1.27-34
  6. Ajith Kumar S, Prasanth P, Tripathi K, Ghosh P. Hyperbaric oxygen-a new horizon in treating cyclophosphamide-induced hemorrhagic cystitis. Indian J Urol IJU J Urol Soc India. 2011;27(2):272-273. doi:10. 4103/0970-1591.82849
  7. Shimura K, Shimazaki C, Taniguchi K, et al. Hyperbaric oxygen in addition to antibiotic therapy is effective for bisphosphonate-induced osteonecrosis of the jaw in a patient with multiple myeloma. Int J Hematol. 2006;84(4):343-345. doi:10.1532/IJH97.06110
  8. Erinjeri JP, Fong AJ, Kemeny NE, Brown KT, Getrajdman GI, Solomon SB. Timing of administration of bevacizumab chemotherapy affects wound healing after chest wall port placement. Cancer. 2011;117(6):1296-1301. doi:10.1002/cncr.25573
  9. Jain KK. Indications, contraindications, and complications of HBO therapy. In: Textbook of Hyperbaric Medicine. 6th ed. Springer; 2017.
  10. Yang TK, Wang YJ, Li HJ, Yu YF, Huang KW, Cheng JCH. Efficacy and safety of hyperbaric oxygen therapy for radiation-induced hemorrhagic cystitis: a systematic review and meta-analysis. J Clin Med. 2024;13(16): 4724. doi:10.3390/jcm13164724
  11. Ganguly BJ, Tonomura N, Benson RM, Osborne BA, Granowitz EV. Hyperbaric oxygen enhances apoptosis in hematopoietic cells. APOPTOSIS. 2002;7(6):499-510. doi:10.1023/A:1020686908831
  12. Canarslan Demir K, Avci AU, Ozgok Kangal MK, et al. Hyperbaric oxygen therapy for managing cancer treatment complications: a safety evaluation. Med Kaunas Lith. 2025;61(3):385. doi:10.3390/medicina 61030385
  13. Gandhi J, Seyam O, Smith NL, Joshi G, Vatsia S, Khan SA. Clinical utility of hyperbaric oxygen therapy in genitourinary medicine. Med Gas Res. 2018;8(1):29-33. doi:10.4103/2045-9912.229601
  14. Crew JP, Jephcott CR, Reynard JM. Radiation-induced haemorrhagic cystitis. Eur Urol. 2001;40(2):111-123. doi:10.1159/000049760
  15. Oscarsson N, Müller B, Rosén A, et al. Radiation-induced cystitis treated with hyperbaric oxygen therapy (RICH-ART): a randomised, controlled, phase 2-3 trial. Lancet Oncol. 2019;20(11):1602-1614. doi:10. 1016/S1470-2045(19)30494-2
  16. Kaur D, Khan SP, Rodriguez V, Arndt C, Claus P. Hyperbaric oxygen as a treatment modality in cyclophosphamide-induced hemorrhagic cystitis. Pediatr Transplant. 2018;22(4):e13171. doi:10.1111/petr.13171
  17. Botta LM, Botta GP. Hemorrhagic cystitis: treatment with hyperbaric oxygen therapy in patients with acute lymphoblastic leukemia. Clin J Oncol Nurs. 2018;22(6):E146-E151. doi:10.1188/18.CJON.E146-E151
  18. Qu Y, Zhao P, Ding X, Qiao X, Wang L, Li Y. Hyperbaric oxygen therapy improves the efficacy of conventional supportive treatment for late-onset hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation. Hematology. 2024;29(1):2356307. doi:10.1080/16078454. 2024.2356307
  19. Zama D, Masetti R, Vendemini F, et al. Clinical effectiveness of early treatment with hyperbaric oxygen therapy for severe late-onset hemorrhagic cystitis after hematopoietic stem cell transplantation in pediatric patients. Pediatr Transplant. 2013;17(1):86-91. doi:10.1111/petr.12031
  20. Ibrahim M, Bhyravabhotla K, Khalaf B, et al. The utility of hyperbaric oxygen therapy in post-transplant cyclophosphamide-induced hemorrhagic cystitis: a case report and review of the literature. J Med Case Reports. 2021;15(1):1. doi:10.1186/s13256-020-02580-w
  21. Camporesi E, Vezzani G, Zanon V, et al. Review on hyperbaric oxygen treatment in femoral head necrosis. Undersea Hyperb Med J Undersea Hyperb Med Soc Inc. 2017;44(6):497-508. doi:10.22462/11.12.2017.1
  22. Gardin C, Bosco G, Ferroni L, et al. Hyperbaric oxygen therapy improves the osteogenic and vasculogenic properties of mesenchymal stem cells in the presence of inflammation in vitro. Int J Mol Sci. 2020;21(4):1452. doi:10.3390/ijms21041452
  23. Bosco G, Vezzani G, Enten G, Manelli D, Rao N, Camporesi EM. Femoral condylar necrosis: treatment with hyperbaric oxygen therapy. Arthroplasty Today. 2018;4(4):510-515. doi:10.1016/j.artd.2018.02.010
  24. Bosco G, Vezzani G, Mrakic Sposta S, et al. Hyperbaric oxygen therapy ameliorates osteonecrosis in patients by modulating inflammation and oxidative stress. J Enzyme Inhib Med Chem. 2018;33(1):1501-1505. doi:10. 1080/14756366.2018.1485149
  25. Bennett M. Hyperbaric oxygen therapy improved both pain scores and range of motion in patients with early idiopathic femoral head necrosis (Ficat stage II). Diving Hyperb Med. 2011;41(2):105.
  26. Li W, Ye Z, Wang W, Wang K, Li L, Zhao D. Clinical effect of hyperbaric oxygen therapy in the treatment of femoral head necrosis: a systematic review and meta-analysis. Orthopade. 2017;46(5):440-446. doi:10.1007/s00132-016-3360-8
  27. Hsu SL, Wang CJ, Lee MSS, Chan YS, Huang CC, Yang KD. Cocktail therapy for femoral head necrosis of the hip. Arch Orthop Trauma Surg. 2010;130(1):23-29. doi:10.1007/s00402-009-0918-5
  28. Camporesi EM, Bosco G. Mechanisms of action of hyperbaric oxygen therapy. Undersea Hyperb Med J Undersea Hyperb Med Soc Inc. 2014; 41(3):247-252.
  29. Camporesi EM, Vezzani G, Bosco G, Mangar D, Bernasek TL. Hyperbaric oxygen therapy in femoral head necrosis. J Arthroplasty. 2010;25(6 Suppl):118-123. doi:10.1016/j.arth.2010.05.005
  30. Haubner F, Ohmann E, Pohl F, Strutz J, Gassner HG. Wound healing after radiation therapy: review of the literature. Radiat Oncol Lond Engl. 2012;7:162. doi:10.1186/1748-717X-7-162
  31. Payne WG, Naidu DK, Wheeler CK, et al. Wound healing in patients with cancer. Eplasty. 2008;8:e9.
  32. Cornell K, Waters DJ. Impaired wound healing in the cancer patient: effects of cytotoxic therapy and pharmacologic modulation by growth factors. Vet Clin North Am Small Anim Pract. 1995;25(1):111-131. doi:10. 1016/s0195-5616(95)50008-7
  33. Bootun R. Effects of immunosuppressive therapy on wound healing. Int Wound J. 2013;10(1):98-104. doi:10.1111/j.1742-481X.2012.00950.x
  34. Kranke P, Bennett MH, Martyn-St James M, Schnabel A, Debus SE, Weibel S. Hyperbaric oxygen therapy for chronic wounds. Cochrane Wounds Group, ed. Cochrane Database Syst Rev. 2015;2015(6):CD004123. doi:10.1002/14651858.CD004123.pub4
  35. Ohgami Y, Elstad CA, Chung E, Shirachi DY, Quock RM, Lai HC. Effect of hyperbaric oxygen on the anticancer effect of artemisinin on molt-4 human leukemia cells. Anticancer Res. 2010;30(11):4467-4470.
  36. Chen YC, Chen SY, Ho PS, et al. Apoptosis of T-leukemia and B-myeloma cancer cells induced by hyperbaric oxygen increased phosphorylation of p38 MAPK. Leuk Res. 2007;31(6):805-815. doi:10. 1016/j.leukres.2006.09.016
  37. Lin TL, Berry A, L. Wise A, et al. Effect of hyperbaric oxygen treatment on chemotherapy sensitivity in acute myeloid leukemia. J Clin Oncol. 2016;34(15_suppl):e18518-e18518. doi:10.1200/JCO.2016.34.15_suppl.e18518
  38. Tonomura N, Granowitz EV. Hyperbaric oxygen: a potential new therapy for leukemia? Leuk Res. 2007;31(6):745-746. doi:10.1016/j.leukres.2006.11.020
  39. Shah A, Andersson TML, Rachet B, Björkholm M, Lambert PC. Survival and cure of acute myeloid leukaemia in England, 1971-2006: a population-based study. Br J Haematol. 2013;162(4):509-516. doi:10. 1111/bjh.12425
  40. Palumbo A, Avet-Loiseau H, Oliva S, et al. Revised international staging system for multiple myeloma: a report from international myeloma working group. J Clin Oncol Off J Am Soc Clin Oncol. 2015;33(26):2863-2869. doi:10.1200/JCO.2015.61.2267
  41. Rosenwald A, Wright G, Chan WC, et al. The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma. N Engl J Med. 2002;346(25):1937-1947. doi:10.1056/NEJMoa012914
  42. Greenberg PL, Tuechler H, Schanz J, et al. Revised international prognostic scoring system for myelodysplastic syndromes. Blood. 2012; 120(12):2454-2465. doi:10.1182/blood-2012-03-420489
  43. Moorman AV, Ensor HM, Richards SM, et al. Prognostic effect of chromosomal abnormalities in childhood B-cell precursor acute lymphoblastic leukaemia: results from the UK Medical Research Council ALL97/99 randomised trial. Lancet Oncol. 2010;11(5):429-438. doi:10.1016/S1470-2045(10)70066-8
  44. Demir AE, Ilbasmis S, Toklu AS. A COVID-19 infection incidentally detected during hyperbaric oxygen treatment and preventive measures for COVID-19 transmission in a multiplace hyperbaric chamber. Diving Hyperb Med. 2022;52(1):58-62. doi:10.28920/dhm52.1.58-62