Dergiler / Journal of Medicine and Palliative Care / 2026 / Volume: 7 Issue: 1

Age-male-albumin-bilirubin-platelet (aMAP) score as a predictor of 28-day mortality in acute pancreatitis

Betül Çiğdem Yortanlı(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, KONYA SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, İÇ HASTALIKLARI ANABİLİM DALI)0000-0003-2698-3159
Hüseyin Mutlu(AKSARAY UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF EMERGENCY MEDICINE)0000-0002-1930-3293
Burak Kocaoğlu(AKSARAY UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF EMERGENCY MEDICINE)0009-0009-7348-6973
Ekrem Taha Sert(AKSARAY UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF EMERGENCY MEDICINE)0000-0002-7208-2186
Kamil Kokulu(AKSARAY UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF EMERGENCY MEDICINE)0000-0002-6132-0898
Ramiz Yazıcı(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İSTANBUL KANUNİ SULTAN SÜLEYMAN SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, ACİL TIP ANABİLİM DALI)0000-0001-9210-914X
Mehmet Yortanlı(Konya Numune Hospital, Department of Emergency Medicine)0000-0002-6744-2423
Sayfa
—
Yayın Tarihi
2026-02-20
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Its ease of calculation and prognostic performance comparable to traditional scoring systems support its practical use in the emergency setting.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:Aims: This study aimed to evaluate the prognostic performance of the age–male–albumin–bilirubin–platelet (aMAP) score in predicting 28-day mortality among patients with acute pancreatitis (AP) presenting to the emergency department (ED).
📊
Temel Bulgular & Veri:Methods: We retrospectively analyzed adult patients diagnosed with AP between January 2020 and December 2024 in a tertiary ED.
💡
Sonuç & Katkı:Its ease of calculation and prognostic performance comparable to traditional scoring systems support its practical use in the emergency setting.
🔬Tür:Research Article
📍Kapsam:2020 Verileri
⚙️Değişkenler:Acute pancreatitis · aMAP score · emergency department

Abstract

Aims: This study aimed to evaluate the prognostic performance of the age–male–albumin–bilirubin–platelet (aMAP) score in predicting 28-day mortality among patients with acute pancreatitis (AP) presenting to the emergency department (ED). Methods: We retrospectively analyzed adult patients diagnosed with AP between January 2020 and December 2024 in a tertiary ED. Demographic characteristics, laboratory findings, clinical parameters, and mortality outcomes were recorded. aMAP scores were calculated using a validated formula. The prognostic performance of the aMAP score was compared with that of ALBI, BISAP, SOFA, and lactate levels using logistic regression and ROC curve analysis. Results: A total of 386 patients were included in the analysis. The median age was significantly higher among non-survivors than survivors (77 vs. 60 years, p<0.001). Levels of aMAP, ALBI, BISAP, SOFA, and lactate were all significantly higher in the non survivor group (p<0.001 for all). In multivariate logistic regression analysis, aMAP (OR: 4.63; 95% CI: 1.50–14.32; p=0.008) and lactate (OR: 1.62; 95% CI: 1.12–2.33; p=0.010) emerged as independent predictors of mortality. ROC analysis demonstrated that lactate had the highest prognostic accuracy (AUC: 0.843), followed by aMAP (AUC: 0.821) and ALBI (AUC: 0.764). Conclusion: These findings indicate that the aMAP score is a simple, accessible, and effective tool for early mortality risk stratification in patients with AP. Its ease of calculation and prognostic performance comparable to traditional scoring systems support its practical use in the emergency setting.

🔖

Bu Makaleye Atıf Yap

Yortanlı, B. Ç., Mutlu, H., Kocaoğlu, B., Sert, E. T., Kokulu, K., Yazıcı, R., Yortanlı, M. (2026). Age-male-albumin-bilirubin-platelet (aMAP) score as a predictor of 28-day mortality in acute pancreatitis. Journal of Medicine and Palliative Care, Volume: 7 Issue: 1. https://doi.org/10.47582/jompac.1868615

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (29)

  1. Mederos MA, Reber HA, Girgis MD. Acute pancreatitis: a review. JAMA. 2021;325:382-390. doi:10.1001/jama.2020.20317
  2. Raraty M, Ward J, Erdemli G, et al. Calcium-dependent enzyme activation and vacuole formation in the apical granular region of pancreatic acinar cells. Proc Natl Acad Sci U S A. 2000;97(24):13126-13131. doi:10.1073/pnas.97.24.13126
  3. Güzel YE, Çolak N, Okuv AC, Teymuroğlu S, Teke Mİ. Comparing prognostic scoring systems in acute pancreatitis: Bedside Index of Severity in Acute Pancreatitis, WL, and Chinese Simple Scoring System Scores. Turk J Emerg Med. 2024;24(3):165-171. doi:10.4103/tjem.tjem_14_24
  4. Barreto SG, Habtezion A, Gukovskaya A, et al. Critical thresholds: key to unlocking the door to the prevention and specific treatments for acute pancreatitis. Gut. 2021;70(1):194-203. doi:10.1136/gutjnl-2020-322163
  5. Buter A, Imrie CW, Carter CR, Evans S, McKay CJ. Dynamic nature of early organ dysfunction determines outcome in acute pancreatitis. Br J Surg. 2002;89(3):298-302. doi:10.1046/j.0007-1323.2001.02025.x
  6. Tenner S, Vege SS, Sheth SG, et al. American College of Gastroenterology Guidelines: management of acute pancreatitis. Am J Gastroenterol. 2024;119(3):419-437. doi:10.14309/ajg.0000000000002645
  7. Wang L, Zeng YB, Chen JY, et al. A simple new scoring system for predicting the mortality of severe acute pancreatitis. Medicine (Baltimore). 2020;99(23):e20646. doi:10.1097/MD.0000000000020646
  8. Zhou H, Mei X, He X, Lan T, Guo S. Severity stratification and prognostic prediction of patients with acute pancreatitis at early phase: a retrospective study. Medicine (Baltimore). 2019;98:e15275. doi:10.1097/MD.0000000000015275
  9. Zhang J, Shahbaz M, Fang R, et al. Comparison of the BISAP scores for predicting the severity of acute pancreatitis in Chinese patients according to the latest Atlanta classification. J Hepato-Biliary-Pancreat Sci. 2014;21(9):689-694. doi:10.1002/jhbp.118
  10. Arif A, Jaleel F, Rashid K. Accuracy of BISAP score in prediction of severe acute pancreatitis. Pak J Med Sci. 2019;35(4):1008-1012. doi:10. 12669/pjms.35.4.1286
  11. Mounzer R, Langmead CJ, Wu BU, et al. Comparison of existing clinical scoring systems to predict persistent organ failure in patients with acute pancreatitis. Gastroenterology. 2012;142(7):1476-1482. doi:10.1053/j.gastro.2012.03.005
  12. Fan R, Papatheodoridis G, Sun J, et al. aMAP risk score predicts hepatocellular carcinoma development in patients with chronic hepatitis. J Hepatol. 2020;73(6):1368-1378. doi:10.1016/j.jhep.2020.07.025
  13. Yang Y, Zhou Y, Zhang X, et al. Using the aMAP risk score to predict late recurrence following radiofrequency ablation for hepatocellular carcinoma in chinese population: a multicenter study. J Hepatocell Carcinoma. 2021;8:837-850. doi:10.2147/JHC.S308587
  14. Sun Y, Li Z, Liao G, et al. aMAP score as a predictor for long-term outcomes in patients with HBV-related acute-on-chronic liver failure. Int J Gen Med. 2022;15:407-415. doi:10.2147/IJGM.S343457
  15. Lee CH, You GR, Jo HG, et al. Albumin-bilirubin grade as a valuable predictor of recurrence and prognosis in patients with hepatocellular carcinoma following radiofrequency ablation. Cancers. 2024;16(24):4167. doi:10.3390/cancers16244167
  16. Shi L, Zhang D, Zhang J. Albumin-bilirubin score is associated with in-hospital mortality in critically ill patients with acute pancreatitis. Eur J Gastroenterol Hepatol. 2020;32(8):963-970. doi:10.1097/MEG. 0000000000001753
  17. Peery AF, Murphy CC, Anderson C, et al. Burden and cost of gastrointestinal, liver, and pancreatic diseases in the United States: update 2024. Gastroenterology. 2025;168(5):1000-1024. doi:10.1053/j.gastro.2024.12.029
  18. Xiao AY, Tan MLY, Wu LM, et al. Global incidence and mortality of pancreatic diseases: a systematic review, meta-analysis, and meta-regression of population-based cohort studies. Lancet Gastroenterol Hepatol. 2016;1(1):45-55. doi:10.1016/S2468-1253(16)30004-8
  19. Wall I, Badalov N, Baradarian R, Iswara K, Li JJ, Tenner S. Decreased mortality in acute pancreatitis related to early aggressive hydration. Pancreas. 2011;40(4):547-550. doi:10.1097/MPA.0b013e318215368d
  20. Xin Y, Zhang X, Yang Y, et al. Prediction of late recurrence after radiofrequency ablation of HBV-related hepatocellular carcinoma with the age-male-albumin-bilirubin-platelets (aMAP) risk score: a multicenter study. J Gastrointest Oncol. 2021;12(6):2930-2942. doi:10. 21037/jgo-21-506
  21. Chen L, Liu Q, Tan C, et al. The age-male-albumin-bilirubin-platelets (aMAP) risk score predicts liver metastasis following surgery for breast cancer in Chinese population: a retrospective study. Immuno Targets Ther. 2024;13:75-94. doi:10.2147/ITT.S446545
  22. Elgenidy A, Abubasheer TM, Odat RM, et al. Assessing the predictive accuracy of the aMAP risk score for hepatocellular carcinoma (HCC): diagnostic test accuracy and meta-analysis. J Clin Exp Hepatol. 2025; 15(1):102381. doi:10.1016/j.jceh.2024.102381
  23. Fan R, Li G, Yu N, et al. aMAP score and its combination with liver stiffness measurement accurately assess liver fibrosis in chronic hepatitis B patients. Clin Gastroenterol Hepatol Off Clin Pract J Am Gastroenterol Assoc. 2023;21(12):3070-3079.e13. doi:10.1016/j.cgh.2023.03.005
  24. Fan R, Yu N, Li G, et al. Machine-learning model comprising five clinical indices and liver stiffness measurement can accurately identify MASLD-related liver fibrosis. Liver Int Off J Int Assoc Study Liver. 2024; 44(3):749-759. doi:10.1111/liv.15818
  25. Chandra S, Murali A, Bansal R, Agarwal D, Holm A. The Bedside Index for Severity in Acute Pancreatitis: a systematic review of prospective studies to determine predictive performance. J Community Hosp Intern Med Perspect. 2017;7(4):208-213. doi:10.1080/20009666.2017.1361292
  26. Sakin A, Sahin S, Sakin A, et al. Assessment of pretreatment albumin-bilirubin grade in pancreatic cancer patients with liver metastasis. J BUON Off J Balk Union Oncol. 2020;25(4):1941-1946.
  27. Jiang X, Su Z, Wang Y, et al. Prognostic nomogram for acute pancreatitis patients: an analysis of publicly electronic healthcare records in intensive care unit. J Crit Care. 2019;50:213-220. doi:10.1016/j.jcrc.2018.10.030
  28. Wu BU, Johannes RS, Sun X, Tabak Y, Conwell DL, Banks PA. The early prediction of mortality in acute pancreatitis: a large population-based study. Gut. 2008;57(12):1698-1703. doi:10.1136/gut.2008.152702
  29. Ye JF, Zhao YX, Ju J, Wang W. Building and verifying a severity prediction model of acute pancreatitis (AP) based on BISAP, MEWS and routine test indexes. Clin Res Hepatol Gastroenterol. 2017;41(5):585-591. doi:10.1016/j.clinre.2016.11.013