Dergiler / Journal of Medicine and Palliative Care / 2026 / Volume: 7 Issue: 3

Clinical evaluation of salivary pH and caries detection using a caries detection device in children diagnosed with molar-incisor hypomineralization

Enes Bardakçı(HARRAN UNIVERSITY, FACULTY OF DENTISTRY, DEPARTMENT OF CLINICAL SCIENCES (FACULTY OF DENTISTRY), DEPARTMENT OF PEDIATRIC DENTISTRY)0009-0007-8557-2946
Mehmet Ali Arslanparçası(HARRAN UNIVERSITY, HEALTH SERVICES VOCATIONAL SCHOOL)0009-0001-2753-2096
Sayfa
—
Yayın Tarihi
2026-06-25
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

The DIAGNOdent device can be used as an auxiliary tool in the evaluation of MIH lesions; however, it should be interpreted in conjunction with clinical examination.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:Aims: Molar–incisor hypomineralization (MIH) is a developmental enamel defect characterized by reduced mineral density, increased porosity, and a higher susceptibility to dental caries.
📊
Temel Bulgular & Veri:Methods: This cross-sectional study included a total of 110 children aged 6-15 years (55 with MIH, 55 healthy controls).
💡
Sonuç & Katkı:The DIAGNOdent device can be used as an auxiliary tool in the evaluation of MIH lesions; however, it should be interpreted in conjunction with clinical examination.
🔬Tür:Modelleme & Sayısal Simülasyon
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Molar-incisor hypomineralization · saliva · fluorescence

Abstract

Aims: Molar–incisor hypomineralization (MIH) is a developmental enamel defect characterized by reduced mineral density, increased porosity, and a higher susceptibility to dental caries. Objective assessment of enamel demineralization and its relationship with salivary factors remains clinically important. The primary objective of this study is to compare DIAGNOdent fluorescence values between children diagnosed with MIH and a healthy control group. The secondary objective is to evaluate the relationship between fluorescence values, salivary pH, and age at the tooth and surface levels. Methods: This cross-sectional study included a total of 110 children aged 6-15 years (55 with MIH, 55 healthy controls). The MIH diagnosis was made according to the criteria of the European Academy of Paediatric Dentistry (EAPD). The level of demineralization on tooth surfaces was measured using the DIAGNOdent Pen device on the mesial, distal, buccal, lingual/palatal, and occlusal surfaces. Three measurements were taken for each surface, and the highest value was recorded. Unstimulated saliva samples were collected to perform pH measurements. Data were analyzed using the Mann–Whitney U test, Chi-square test, and Spearman correlation analysis (p 0.05). However, significantly higher DIAGNOdent values were observed in the MIH group, particularly in the posterior teeth and the maxillary region (p<0.001). No significant differences were found between the groups regarding anterior teeth and the mandibular region. In both groups, weak negative correlations were observed between age and DIAGNOdent values in the anterior teeth, and weak positive correlations with pH, whereas these correlations were not significant in the posterior teeth. These findings were further confirmed by linear mixed-effects model analysis controlling for intra-individual variability, supporting that the surface-based analytical approach provides a more detailed and clinically relevant evaluation of hypomineralized enamel. Conclusion: In the presence of MIH, DIAGNOdent measurements show a marked increase, particularly in the posterior teeth, reflecting structural changes characteristic of hypomineralized enamel. The relationship between DIAGNOdent values and age and saliva pH varies depending on the tooth and surface type. Although saliva pH did not differ between groups, it may play a modulatory role in the pathogenesis of MIH. The DIAGNOdent device can be used as an auxiliary tool in the evaluation of MIH lesions; however, it should be interpreted in conjunction with clinical examination.

🔖

Bu Makaleye Atıf Yap

Bardakçı, E., Arslanparçası, M. A. (2026). Clinical evaluation of salivary pH and caries detection using a caries detection device in children diagnosed with molar-incisor hypomineralization. Journal of Medicine and Palliative Care, Volume: 7 Issue: 3. https://doi.org/10.47582/jompac.1927120

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (27)

  1. Lopes LB, Machado V, Mascarenhas P, Mendes JJ, Botelho J. The prevalence of molar-incisor hypomineralization: a systematic review and meta-analysis. Sci Rep. 2021;11(1):22405. doi:10.1038/s41598-021-01541-7
  2. Sluka B, Held U, Wegehaupt FJ, Neuhaus KW, Attin T, Sahrmann P. Is there a rise of prevalence for molar incisor hypomineralization? A meta-analysis of published data. BMC Oral Health. 2024;24(1):127. doi:10. 1186/s12903-023-03637-0
  3. Neto TS, Reis PM dos, Pinchemel ENB, Duarte ACA. Molar and incisor hypomineralization: challenge from diagnosis to therapeutic possibilities. Res Soc Dev. 2023;12(13):e131121344354-e131121344354. doi:10.33448/rsd-v12i13.44354
  4. Amaechi BT, Farah R, Liu J, et al. Remineralization of molar incisor hypomineralization (MIH) with a hydroxyapatite toothpaste: an in-situ study. Res Sq Res Sq. 2022. doi:10.21203/rs.3.rs-2187889/v1
  5. Rexhaj F, Sabel N, Robertson A, Lundgren T. Proteomic profiling of human dental enamel affected by molar incisor hypomineralisation of different clinical severity grades: an in vitro study. Eur Arch Paediatr Dent. 2024;25(4):533-545. doi:10.1007/s40368-024-00911-9
  6. Jähn-Rickert K, Krug J, Lotze G, et al. Structural porosity and low mineral density in enamel rods drive molar incisor hypomineralisation. Adv Funct Mater. 2026:e24830. doi:10.1002/adfm.202524830
  7. Ustaoğlu S, Akal N. Steps to optimize bond strength to molar incisor hypomineralization affected enamel. Istanb Univ J. 2022;4(2):55-60.
  8. Mazur M, Corridore D, Ndokaj A, et al. MIH and dental caries in children: a systematic review and meta-analysis. Healthcare. 2023;11(12): 1795-1795. doi:10.3390/healthcare11121795
  9. Hoyte T. Cross-sectional survey to ascertain the prevalence of molar incisor hypo-mineralization in the Trinidad and Tobago population. Am J Biomed Sci Res. 2020;7(3):204-207. doi:10.34297/ajbsr.2020.07.001141
  10. Schoeffel AC, Rolim TZC, Souza LG de, et al. Impact of molar incisor hypomineralization and hypersensitivity on oral health-related quality of life. Res Sq Res Sq. 2024. doi:10.21203/rs.3.rs-4103169/v1
  11. Ortega-Luengo S, García GF, Miegimolle M, López NEG, Caleya AM. Prevalence and clinical presentation of molar incisor hypomineralisation among a population of children in the community of Madrid. BMC Oral Health. 2024;24(1):229. doi:10.1186/s12903-024-04003-4
  12. Galuscan A, Jumanca D, Fratila AD. Caries management aided by fluorescence-based devices. In: Dental caries-the selection of restoration methods and restorative materials. IntechOpen; 2022. doi:10.5772/intechopen.105567
  13. Araujo E, Vidal C, Freitas A, Wetter N, Matos A. Characterization of sound enamel and natural white spot lesions. Braz Dent Sci. 2022;25: e3488. doi:10.4322/bds.2022.e3488
  14. Altan H, Yılmaz RE. Clinical evaluation of resin infiltration treatment masking effect on hypomineralised enamel surfaces. BMC Oral Health. 2023;23(1):444. doi:10.1186/s12903-023-03140-6
  15. Dias A, Colodette RM, Rodrigues GMA. Hipomineralização molar incisivo e sua associação com cárie dentária: Uma revisão sistemática e meta-análise. Res Soc Dev. 2025;14(10):e61141049697-e61141049697. doi: 10.33448/rsd-v14i10.49697
  16. Enax J, Fandrich P, Wiesche ES zur, Epple M. The remineralization of enamel from saliva: a chemical perspective. Dent J. 2024;12(11):339-339. doi:10.3390/dj12110339
  17. Pappa E, Vastardis H, Makridakis M, et al. Analysis of human and microbial salivary proteomes in children offers insights on the molecular pathogenesis of molar-incisor hypomineralization. Biomedicines. 2022; 10(9):2061-2061. doi:10.3390/biomedicines10092061
  18. Ezhumalai G, Prathima GS, Narmatha M, Arumugam S. Effects of xylitol and CPP-ACP chewing gum on salivary properties of children with molar incisor hypomineralization. Int J Clin Pediatr Dent. 2021; 14(3):412-415. doi:10.5005/jp-journals-10005-1779
  19. Afzal SH, Skaare AB, Wigen TI, Brusevold IJ. Molar-incisor hypomineralisation: severity, caries and hypersensitivity. J Dent. 2024; 142:104881-104881. doi:10.1016/j.jdent.2024.104881
  20. Lygidakis NA, Garot E, Somani C, Taylor GD, Rouas P, Wong FSL. Best clinical practice guidance for clinicians dealing with children presenting with molar-incisor-hypomineralisation (MIH): an updated European Academy of Paediatric Dentistry policy document. Eur Arch Paediatr Dent. 2022;23(1):3-21. doi:10.1007/s40368-021-00668-5
  21. Al-Nerabieah Z, AlKhouli M, Dashash M. Assessment of diagnostic accuracy and reliability of reveal fluorescence dental loupes in detecting molar incisor hypomineralization in children. Photodiagnosis Photodyn Ther. 2024;46:104033. doi:10.1016/j.pdpdt.2024.104033
  22. Farah RA, Drummond BK, Swain MV, Williams S. Relationship between laser fluorescence and enamel hypomineralisation. J Dent. 2008;36(11):915-921. doi:10.1016/j.jdent.2008.07.012
  23. Şen Yavuz B, Sezer B, Kaya R, Tuğcu N, Kargül B. Is there an association between molar incisor hypomineralization and developmental dental anomalies? A case-control study. BMC Oral Health. 2023;23(1):776. doi: 10.1186/s12903-023-03540-8
  24. Ismayilova N, Güngör Ö, Karayılmaz H. Assessment of severity and mineral composition of saliva in schoolchildren with molar-incisor hypomineralization (MIH). J Clin Pediatr Dent. 2024;48(3):86-93. doi: 10.22514/jocpd.2024.024
  25. Akkus A, Karasik D, Roperto R. Correlation between micro-hardness and mineral content in healthy human enamel. J Clin Exp Dent. 2017; 9(4):e569-e573. doi:10.4317/jced.53345
  26. Jaafar N, Ragab H, Abedrahman A, Osman E. An in vivo investigation of diagnostic performance of DIAGNOdent pen and the canary system for assessment and monitoring enamel caries under fissure sealants. J Int Soc Prev Community Dent. 2020;10(3):246-254. doi:10.4103/jispcd.JISPCD_480_19
  27. Ko CC, Yi DH, Lee DJ, Kwon J, Garcia-Godoy F, Kwon YH. Diagnosis and staging of caries using spectral factors derived from the blue laser-induced autofluorescence spectrum. J Dent. 2017;67:77-83. doi:10.1016/j.jdent.2017.09.015