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Dergiler / Journal of Health Sciences and Medicine / 2026 / Volume: 5 Issue: 3

The diagnostic value of calcium binding protein S100A8/A9 and S100A12 in acute pancreatitis

Okan Bardakcı(CANAKKALE ONSEKIZ MART UNIVERSITY, ÇANAKKALE HEALTH ACADEMY)0000-0001-6829-7435
Murat Daş(CANAKKALE ONSEKIZ MART UNIVERSITY, ÇANAKKALE HEALTH ACADEMY)0000-0003-0893-6084
Hilal Şehitoğlu(CANAKKALE ONSEKIZ MART UNIVERSITY, ÇANAKKALE HEALTH ACADEMY)0000-0003-4436-9160
Ece Ünal Çetin(CANAKKALE ONSEKIZ MART UNIVERSITY, ÇANAKKALE HEALTH ACADEMY)0000-0002-0933-7764
Ünzile Atalay(CANAKKALE ONSEKIZ MART UNIVERSITY, ÇANAKKALE HEALTH ACADEMY)0000-0001-7665-6514
Uğur Küçük(CANAKKALE ONSEKIZ MART UNIVERSITY, ÇANAKKALE HEALTH ACADEMY)0000-0003-4669-7387
Fatih Kamış(CANAKKALE ONSEKIZ MART UNIVERSITY, ÇANAKKALE HEALTH ACADEMY)0000-0003-2913-6166
Alpaslan Tanoğlu(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İSTANBUL SANCAKTEPE ŞEHİR PROF. DR. İLHAN VARANK SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, İÇ HASTALIKLARI ANABİLİM DALI)0000-0002-7477-6640
Yavuz Beyazıt(CANAKKALE ONSEKIZ MART UNIVERSITY, ÇANAKKALE HEALTH ACADEMY)0000-0001-6247-2714
Sayfa
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Yayın Tarihi
2022-05-30
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Yapay Zeka Hızlı Bakış & Çıkarımlar

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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Both of these markers might serve as an additional tool in the diagnostic workup in AP since S100A8/A9 and S100A12 were significantly correlated with CRP.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Background: S100A8/A9 and S100A12 which are the major calcium-binding proinflammatory proteins secreted by granulocytes, has been proposed to be related to distinct disease states of inflammatory origin.
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Temel Bulgular & Veri:This study aims to explore the circulating levels of S100A8/A9 and S100A12 in acute pancreatitis (AP) and reveal their relationship with conventional inflammatory markers.
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Sonuç & Katkı:Both of these markers might serve as an additional tool in the diagnostic workup in AP since S100A8/A9 and S100A12 were significantly correlated with CRP.
🔬Tür:Research Article
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Acute pancreatitis · S100A8/A9 · S100A12

Abstract

Background: S100A8/A9 and S100A12 which are the major calcium-binding proinflammatory proteins secreted by granulocytes, has been proposed to be related to distinct disease states of inflammatory origin. This study aims to explore the circulating levels of S100A8/A9 and S100A12 in acute pancreatitis (AP) and reveal their relationship with conventional inflammatory markers. Material and Method: Serum S100A8/A9 and S100A12 were determined in AP patients (male/female: 17/13) by using a specific enzyme-linked immunosorbent assay (ELISA) method at both onset and remission and in 30 healthy controls (male/female: 17/13). Results: Significantly higher S100A8/A9 and S100A12 levels were found in AP patients compared to healthy controls (p<0.001). Circulating levels of S100A8/9, S100A12 and C-reactive protein (CRP) were found to be elevated in AP patients at disease onset compared with remission. The correlation analysis demonstrated a significant association between S100A8/A9 and S100A12 (r=0.366, p=0.047). The cut-off level for S100A8/A9 for detecting AP was ≥54.4 ng/ml with a sensitivity and specificity of 96.7% and 73.3% (AUC: 0.958). The optimum cut-off level for S100A12 for detecting AP was ≥350.25 ng/ml with a sensitivity and specificity of 73.3% and 76.7% (AUC: 0.752) respectively. Conclusion: Circulating S100A8/A9 and S100A12 levels were found to be elevated in AP patients. Both of these markers might serve as an additional tool in the diagnostic workup in AP since S100A8/A9 and S100A12 were significantly correlated with CRP.

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Bu Makaleye Atıf Yap

Bardakcı, O., Daş, M., Şehitoğlu, H., Çetin, E. Ü., Atalay, Ü., Küçük, U., Kamış, F., Tanoğlu, A., Beyazıt, Y. (2022). The diagnostic value of calcium binding protein S100A8/A9 and S100A12 in acute pancreatitis. Journal of Health Sciences and Medicine, Volume: 5 Issue: 3. https://doi.org/10.32322/jhsm.1096501

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Kaynakça (27)

  1. Yadav D, Lowenfels AB. The epidemiology of pancreatitis and pancreatic cancer. Gastroenterology 2013; 144: 1252-61.
  2. Gumaste VV. Diagnostic tests for acute pancreatitis. Gastroenterologist. 1994; 2: 119-30.
  3. Foell D, Roth J. Proinflammatory S100 proteins in arthritis and autoimmune disease. Arthritis Rheum 2004; 50: 3762-71
  4. Manolakis AC, Kapsoritakis AN, Georgoulias P, et al. Moderate performance of serum S100A12, in distinguishing inflammatory bowel disease from irritable bowel syndrome. BMC Gastroenterol 2010; 10: 118.
  5. Liu K, Pichichero ME. Clinical significance of serum S100A12 in acute otitis media in young children. Pediatr Infect Dis J 2012; 3: e56-8.
  6. Gohar F, Anink J, Moncrieffe H, et al. S100A12 Is Associated with Response to Therapy in Juvenile Idiopathic Arthritis. J Rheumatol 2018; 45: 547-54
  7. Hinze CH, Foell D, Johnson AL, et al. Serum S100A8/A9 and S100A12 Levels in children with polyarticular forms of juvenile idiopathic arthritis: relationship to maintenance of clinically inactive disease during anti-tumor necrosis factor therapy and occurrence of disease flare after discontinuation of therapy. Arthritis Rheumatol 2019; 71: 451-9.
  8. Prystupa A, Kiciński P, Luchowska-Kocot D, et al. Analysis of novel serum markers of fibrosis and angiogenesis in patients with alcoholic liver cirrhosis. Ann Agric Environ Med 2020; 27: 568-73.
  9. Şumnu Ş, Mehtap Ö, Mersin S, et al. Serum calprotectin (S100A8/A9) levels as a new potential biomarker of treatment response in Hodgkin lymphoma. Int J Lab Hematol 202; 43: 638-44
  10. Müller I, Vogl T, Kühl U, et al. Serum alarmin S100A8/S100A9 levels and its potential role as biomarker in myocarditis. ESC Heart Fail 2020; 7: 1442-51.
  11. Banks PA, Bollen TL, Dervenis C, et al. Acute Pancreatitis Classification Working Group. Classification of acute pancreatitis--2012: revision of the Atlanta classification and definitions by international consensus. Gut 2013; 62: 102-11.
  12. van Dijk SM, Hallensleben NDL, van Santvoort HC, et al. Acute pancreatitis: recent advances through randomised trials. Gut 2017; 66: 2024-32.
  13. Vatansever S, Doğru R, Pakoz ZB, Genç H, Ünsal B. Evaluation of laboratory findings and mortality in elderly patients with acute biliary pancreatitis. Sisli Etfal Hastan Tip Bul 2018; 52: 274-8.
  14. Ünal Çetin E, Kamiş F, Çetin AU, Beyazit Y, Kekilli M. Serum chitotriosidase and YKL-40 in acute pancreatitis: Reliability as prognostic marker for disease severity and correlation with inflammatory markers. Turk J Med Sci 2021; 51: 3038-46.
  15. Gezer NS, Bengi G, Baran A, et al. Comparison of radiological scoring systems, clinical scores, neutrophil-lymphocyte ratio and serum C-reactive protein level for severity and mortality in acute pancreatitis. Rev Assoc Med Bras (1992) 2020; 66: 762-70.
  16. Rasslan R, Novo FDCF, Bitran A, Utiyama EM, Rasslan S. Management of infected pancreatic necrosis: state of the art. Rev Col Bras Cir 2017; 44: 521-9.
  17. Korkmaz H, Tabur S, Savaş E, et al. Evaluation of serum S100A8/S100A9 levels in patients with autoimmune thyroid diseases. Balkan Med J 2016; 33: 547-51.
  18. van Bon L, Cossu M, Loof A, et al. Proteomic analysis of plasma identifies the Toll-like receptor agonists S100A8/A9 as a novel possible marker for systemic sclerosis phenotype. Ann Rheum Dis 2014 A; 73: 1585-9.
  19. Kessel C, Lavric M, Weinhage T, et al. Serum biomarkers confirming stable remission in inflammatory bowel disease. Sci Rep 2021; 11: 6690.
  20. Türkmenoğlu Y, Güney E, Bezen D, İrdem A, Ertürk B, Dursun H. Evaluation of S100A12 protein levels in children with familial Mediterranean fever. Turk J Med Sci 2021; 51: 1396-1405.
  21. van den Bos C, Roth J, Koch HG, Hartmann M, Sorg C. Phosphorylation of MRP14, an S100 protein expressed during monocytic differentiation, modulates Ca(2+)-dependent translocation from cytoplasm to membranes and cytoskeleton. J Immunol. 1996; 156: 1247-54
  22. Hu W, Lin C. S100a8 silencing attenuates inflammation, oxidative stress and apoptosis in BV2 cells induced by oxygen glucose deprivation and reoxygenation by upregulating GAB1 expression. Mol Med Rep 2021; 23: 64.
  23. El Gammal AT, Sturm JH, Pinnschmidt HO, et al. Protein S100A8/A9: A potential new biomarker for pancreatic diseases. Int J Clin Endocrinol Metab 2017;3: 23-8.
  24. Foell D, Roth J. Proinflammatory S100 proteins in arthritis and autoimmune disease. Arthritis Rheum 2004; 50:3762-71.
  25. Cai J, Han T, Nie C, et al. Biomarkers of oxidation stress, inflammation, necrosis and apoptosis are associated with hepatitis B-related acute-on-chronic liver failure. Clin Res Hepatol Gastroenterol 2016; 40: 41-50.
  26. Aljaberi N, Tronconi E, Schulert G, et al. The use of S100 proteins testing in juvenile idiopathic arthritis and autoinflammatory diseases in a pediatric clinical setting: a retrospective analysis. Pediatr Rheumatol Online J 2020; 18: 7
  27. Feng Z, Yinchu Z, Yinsheng S, et al. Potential effects of calcium binding protein S100A12 on severity evaluation and curative effect of severe acute pancreatitis. Inflammation 2015; 38: 290-7.