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Dergiler / Journal of Health Sciences and Medicine / 2026 / Volume: 6 Issue: 5

The relationship between serum soluble ACE 2 protein level and the clinical course of COVID-19 disease

Derya Korkmaz(AFYONKARAHISAR HEALTH SCIENCES UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF INFECTIOUS DISEASES)0000-0001-7236-2164
Tülay Köken(AFYONKARAHISAR HEALTH SCIENCES UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF BASIC MEDICAL SCIENCES, DEPARTMENT OF BIOCHEMISTRY)0000-0001-5510-9415
Halit Buğra Koca(AFYONKARAHISAR HEALTH SCIENCES UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF BASIC MEDICAL SCIENCES, DEPARTMENT OF BIOCHEMISTRY)0000-0002-5353-3228
Semiha Orhan(AFYONKARAHISAR HEALTH SCIENCES UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF SURGICAL MEDICAL SCIENCES, DEPARTMENT OF ANESTHESIOLOGY, INTENSIVE CARE (MEDICINE))0000-0003-2617-6197
Neşe Demirtürk(AFYONKARAHISAR HEALTH SCIENCES UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF INFECTIOUS DISEASES)0000-0002-6186-2494
Sayfa
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Yayın Tarihi
2023-09-28
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Studies in larger patient populations are needed to explain the relationship between sACE 2 activity and SARS-CoV-2 infection and to develop new treatment strategies.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Aims: The angiotensin converting enzyme 2 (ACE 2) molecule, which mediates the entry of the virus into the cell, plays a very important role in the pathogenesis of COVID-19 disease.
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Temel Bulgular & Veri:In this study, it was aimed to investigate the relationship between soluble ACE 2 (sACE 2) levels in the blood and the course of the disease.
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Sonuç & Katkı:Studies in larger patient populations are needed to explain the relationship between sACE 2 activity and SARS-CoV-2 infection and to develop new treatment strategies.
🔬Tür:Research Article
📍Kapsam:2020 Verileri
⚙️Değişkenler:COVID-19 · angiotensin converting enzyme 2 · prognosis

Abstract

Aims: The angiotensin converting enzyme 2 (ACE 2) molecule, which mediates the entry of the virus into the cell, plays a very important role in the pathogenesis of COVID-19 disease. However, its effect on prognosis has not been fully explained. In this study, it was aimed to investigate the relationship between soluble ACE 2 (sACE 2) levels in the blood and the course of the disease. Methods: sACE 2 levels at 0, 3 and 5 days were measured in patients with mild, moderate and severe COVID-19 pneumonia who were hospitalized between March 15, 2020 and August 30, 2020. Results: 69 patients, 35 (51.5%) female and 34 (49.3%) male, with a mean age of 64.3±2.1 were included in the study. 42.0% of the patients had mild, 30.4% moderate, 27.5% severe pneumonia. Clinical follow-up of 7 patients resulted in death. There was no statistically significant difference between sACE 2 levels and gender, severity of pneumonia, initial hospitalization, presence of intubation and mortality. Conclusion: sACE 2 levels were not associated with disease severity and inflammatory markers. Studies in larger patient populations are needed to explain the relationship between sACE 2 activity and SARS-CoV-2 infection and to develop new treatment strategies.

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Bu Makaleye Atıf Yap

Korkmaz, D., Köken, T., Koca, H. B., Orhan, S., Demirtürk, N. (2023). The relationship between serum soluble ACE 2 protein level and the clinical course of COVID-19 disease. Journal of Health Sciences and Medicine, Volume: 6 Issue: 5. https://doi.org/10.32322/jhsm.1343953

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