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Dergiler / Journal of Health Sciences and Medicine / 2026 / Volume: 9 Issue: 3

Comparison of gastrointestinal symptom burden, dietary habits, and quality of life between women with Hashimoto’s thyroiditis and healthy controls: a cross-sectional study

Şevval Kılınç(Istanbul Aydin University Faculty of Health Sciences, Department of Nutrition and Dietetics)0000-0001-8816-3928
Zeynep Begüm Kalyoncu Atasoy(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, GÜLHANE SAĞLIK BİLİMLERİ FAKÜLTESİ)0000-0001-6208-3540
Sayfa
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Yayın Tarihi
2026-05-19
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These findings suggest that care for women with HT may benefit from attention to dietary pattern quality, individualized dietary counseling, routine GI symptom assessment, and support for regular physical activity.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Aims: To compare nutrition-related behaviors, gastrointestinal (GI) symptoms, food insecurity, and health-related quality of life between women with Hashimoto thyroiditis (HT) and healthy controls, and to explore factors associated with HT.
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Temel Bulgular & Veri:Methods: In this case-control study conducted in Adana, Turkiye, 214 adult women (107 HT; 107 controls) completed a face-to-face questionnaire including a nutrition habits survey, the Mediterranean Diet Adherence Screener (MEDAS), the Food Insecurity Experience Scale (FIES), the Gastrointestinal Symptom Rating Scale (GSRS), and the Short Form-36 (SF-36).
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Sonuç & Katkı:These findings suggest that care for women with HT may benefit from attention to dietary pattern quality, individualized dietary counseling, routine GI symptom assessment, and support for regular physical activity.
🔬Tür:Uygulamalı Anket & Alan Araştırması
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Hashimoto disease · autoimmune thyroiditis · Mediterranean diet

Abstract

Aims: To compare nutrition-related behaviors, gastrointestinal (GI) symptoms, food insecurity, and health-related quality of life between women with Hashimoto thyroiditis (HT) and healthy controls, and to explore factors associated with HT. Methods: In this case-control study conducted in Adana, Turkiye, 214 adult women (107 HT; 107 controls) completed a face-to-face questionnaire including a nutrition habits survey, the Mediterranean Diet Adherence Screener (MEDAS), the Food Insecurity Experience Scale (FIES), the Gastrointestinal Symptom Rating Scale (GSRS), and the Short Form-36 (SF-36). Group comparisons used chi-square and Mann-Whitney U tests, correlations were assessed with Spearman’s rho, logistic regression explored factors associated with HT, and path analysis examined interrelationships among food insecurity, MEDAS, GSRS, and SF-36. Results: Compared with controls, the HT group had lower Mediterranean diet adherence (median MEDAS 7 vs 8; p=0.023), higher constipation and reflux symptom scores (p=0.006 and p=0.023), and lower mental health scores (SF-36 mental health; p<0.001). In univariable analysis, higher MEDAS was inversely associated with HT (OR=0.834; p=0.005). In multivariable analysis, regular exercise remained inversely associated with HT (OR≈0.38; p=0.012). Higher GI symptom burden was associated with lower SF-36 scores (β≈-4.11 per unit; p<0.001). Food insecurity did not differ significantly between groups. Conclusion: HT was associated with poorer GI symptom profiles and lower Mediterranean diet adherence. These findings suggest that care for women with HT may benefit from attention to dietary pattern quality, individualized dietary counseling, routine GI symptom assessment, and support for regular physical activity.

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Bu Makaleye Atıf Yap

Kılınç, Ş., Atasoy, Z. B. K. (2026). Comparison of gastrointestinal symptom burden, dietary habits, and quality of life between women with Hashimoto’s thyroiditis and healthy controls: a cross-sectional study. Journal of Health Sciences and Medicine, Volume: 9 Issue: 3. https://doi.org/10.32322/jhsm.1887152

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Kaynakça (28)

  1. Klubo-Gwiezdzinska J, Wartofsky L. Hashimoto thyroiditis: an evidence-based guide to etiology, diagnosis and treatment. Pol Arch Intern Med. 2022;132(3):16222. doi:10.20452/pamw.16222
  2. Zhang H, Tong W, Zeng W, et al. Persistent symptoms in euthyroid Hashimoto’s thyroiditis: current hypotheses and emerging management strategies. Front Endocrinol (Lausanne). 2025;16:1627787. doi:10.3389/fendo.2025.1627787
  3. Ludgate ME, Masetti G, Soares P. The relationship between the gut microbiota and thyroid disorders. Nat Rev Endocrinol. 2024;20(9):511-525. doi:10.1038/s41574-024-01003-w
  4. Gong B, Wang C, Meng F, et al. Association between gut microbiota and autoimmune thyroid disease: a systematic review and meta-analysis. Front Endocrinol (Lausanne). 2021;12:774362. doi:10.3389/fendo.2021. 774362
  5. Tomov DG, Levterova BA, Mihailova VN, et al. Influence of the increase in intestinal permeability and microbiota change in the development of Hashimoto’s thyroiditis: systematic review. Endocr Metab Sci. 2024;16: 100195. doi:10.1016/j.endmts.2024.100195
  6. Xu GM, Hu MX, Li SY, Ran X, Zhang H, Ding XF. Thyroid disorders and gastrointestinal dysmotility: an old association. Front Physiol. 2024;15: 1389113. doi:10.3389/fphys.2024.1389113
  7. Patti M, Christian R, Palokas M. Association between anti-thyroid antibodies and quality of life in patients with Hashimoto thyroiditis: a systematic review and meta-analysis. JBI Evid Synth. 2021;19(9):2307-2338. doi:10.11124/JBIES-20-00043
  8. Ruggeri RM, Barbalace MC, Croce L, et al. Autoimmune thyroid disorders: the Mediterranean diet as a protective choice. Nutrients. 2023;15(18):3953. doi:10.3390/nu15183953
  9. Kimble R, Gouinguenet P, Ashor A, et al. Effects of a Mediterranean diet on the gut microbiota and microbial metabolites: a systematic review of randomized controlled trials and observational studies. Crit Rev Food Sci Nutr. 2023;63(27):8698-8719. doi:10.1080/10408398.2022.2057416
  10. Pourmotabbed A, Moradi S, Babaei A, et al. Food insecurity and mental health: a systematic review and meta-analysis. Public Health Nutr. 2020; 23(10):1778-1790. doi:10.1017/S136898001900435X
  11. Korkmaz EA. Hashimato Hastalığına Bağlı Hipotiroidik Hastalarda Nötrofil-Lenfosit Oranı ve Vücut Yağ Oranının Karşılaştırılması / Comparison of Neutrofile-Lymphocyte Ratio and Body Oil Rate in Hypothyroidic Diseases During Hashimoto Disease. Tıpta Uzmanlık Tezi. Harran Üniversitesi; 2017. Accessed February 11, 2026. https://tez.yok.gov.tr/UlusalTezMerkezi/tezDetay.jsp?id=7J96dAoH8m8Hw_ 8ghdO0og&no=PjAuwOjqIqWzlbINVSqQ9A
  12. T.C. Sağlık Bakanlığı. Turkiye Beslenme ve Sağlık Araştırması (TBSA) 2019. Sağlık Bakanlığı; 2019. Accessed October 24, 2021.
  13. Koç İ, Kaptanoğlu İY, Eryurt MA. Turkiye Nüfus ve Sağlık Araştırması (TNSA) 2013. Hacettepe Üniversitesi Nüfus Etütleri Enstitüsü; 2014.
  14. World Health Organization. Obesity and overweight. Accessed February 9, 2022. https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight
  15. Pehlivanoğlu EFÖ, Balcıoğlu H, Ünlüoğlu İ. Akdeniz Diyeti Bağlılık Ölçeği’nin Türkçe’ye uyarlanması geçerlilik ve güvenilirliği. Osmangazi Tıp Derg. 2020;42(2):160-164. doi:10.20515/otd.504188
  16. Ballard TJ, Kepple AW, Cafiero C. The Food Insecurity Experience Scale: Development of a Global Standard for Monitoring Hunger Worldwide. FAO; 2013.
  17. Svedlund J, Sjödin I, Dotevall G. GSRS-a clinical rating scale for gastrointestinal symptoms in patients with irritable bowel syndrome and peptic ulcer disease. Dig Dis Sci. 1988;33(2):129-134. doi:10.1007/BF01535722
  18. Turan N, Aştı TA, Kaya N. Reliability and validity of the Turkish version of the Gastrointestinal Symptom Rating Scale. Gastroenterol Nurs. 2017; 40(1):47-55. doi:10.1097/SGA.0000000000000177
  19. Demiral Y, Ergor G, Unal B, et al. Normative data and discriminative properties of short form 36 (SF-36) in Turkish urban population. BMC Public Health. 2006;6:247. doi:10.1186/1471-2458-6-247
  20. Groenewegen KL, Mooij CF, van Trotsenburg ASP. Persisting symptoms in patients with Hashimoto’s disease despite normal thyroid hormone levels: does thyroid autoimmunity play a role? A systematic review. J Transl Autoimmun. 2021;4:100101. doi:10.1016/j.jtauto.2021.100101
  21. Perros P, Van Der Feltz-Cornelis C, Papini E, Nagy EV, Weetman AP, Hegedüs L. The enigma of persistent symptoms in hypothyroid patients treated with levothyroxine: a narrative review. Clin Endocrinol (Oxf). 2023;98(4):461-468. doi:10.1111/cen.14473
  22. Taşkaldıran I, Altay FP, Bozkuş Y, et al. The effect of COVID-19 vaccines on thyroid function and thyroid autoimmunity. J Health Sci Med. 2023;6(5):948-953. doi:10.32322/jhsm.1326088
  23. Keshani M, Rafiee S, Heidari H, Rouhani MH, Sharma M, Bagherniya M. Mediterranean diet reduces inflammation in adults: a systematic review and meta-analysis of randomized controlled trials. Nutr Rev. 2025. doi:10.1093/nutrit/nuaf213
  24. Küçükkasap T, Topkaya MS. Health cooking at home: can cooking skills reduce gastrointestinal symptoms, cross sectional study? BMC Gastroenterol. 2025;25(1):759. doi:10.1186/s12876-025-04365-1
  25. Wolfson JA, Garcia T, Leung CW. Food insecurity is associated with depression, anxiety, and stress: evidence from the early days of the COVID-19 pandemic in the United States. Health Equity. 2021;5(1):64-71. doi:10.1089/heq.2020.0059
  26. Sparling TM, Deeney M, Cheng B, et al. Systematic evidence and gap map of research linking food security and nutrition to mental health. Nat Commun. 2022;13(1):4608. doi:10.1038/s41467-022-32116-3
  27. Yaman A, Özdemir O, Gök Ş, Karahan S, Gökçe Kutsal Y. The effect of physical activity level on quality of life in women with postmenopausal osteoporosis. J Health Sci Med. 2025;8(2):286-291. doi:10.32322/jhsm. 1613970
  28. Schmitz N, Kruse J. The SF-36 summary scores and their relation to mental disorders: physical functioning may affect performance of the summary scores. J Clin Epidemiol. 2007;60(2):163-170. doi:10.1016/j.jclinepi.2006.04.003