Yapay Zeka Hızlı Bakış & Çıkarımlar
AI InsightThese findings suggest that prognostic assessment in CAP should be guided by clinical severity and host vulnerability rather than chronological age alone.
📌 3 Maddede Bu Makale
Abstract
Aims: Community-acquired pneumonia (CAP) remains a major cause of hospitalization and mortality worldwide, particularly among older adults. Although advanced age is commonly associated with adverse outcomes, its independent contribution to mortality remains uncertain. To evaluate the impact of age on 6-month mortality in hospitalized patients with CAP and to identify independent predictors of mortality. Methods: This retrospective single center cohort study included 613 patients aged 50 years and older who were hospitalized with CAP between January 2018 and January 2025. Patients were stratified into three age groups: 50-64 years (n=116), 65-79 years (n=280), and ≥80 years (n=217). Demographic characteristics, comorbidities, disease severity, microbiological findings, laboratory parameters, and clinical outcomes were compared among groups. Factors associated with 6-month mortality were evaluated using univariate and multivariable logistic regression analyses. Results: Older patients had a higher burden of comorbidities, poorer functional status, and higher CURB-65 scores. However, 6-month mortality rates did not differ significantly among age groups (5.2%, 5.7%, and 7.8%, respectively; p=0.532). In multivariable logistic regression analysis, immunosuppression (OR: 7.239, 95% CI: 1.894-27.676; p=0.004), high-risk CURB-65 classification (OR: 3.980, 95% CI: 1.235-12.827; p=0.021), and lower admission pH (OR: 0.161, 95% CI: 0.084-0.309; p<0.001) were independently associated with mortality. Age was not independently associated with 6-month mortality (OR: 1.004, 95% CI: 0.965-1.045; p=0.831). Conclusion: Although advanced age was associated with greater comorbidity burden and disease severity at presentation, it was not an independent predictor of 6-month mortality among hospitalized patients with CAP. Mortality was independently associated with immunosuppression, high-risk CURB-65 classification, and impaired acid base status at presentation. These findings suggest that prognostic assessment in CAP should be guided by clinical severity and host vulnerability rather than chronological age alone.