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Dergiler / Journal of Health Sciences and Medicine / 2026 / Volume: 9 Issue: 5

Association of pre-biopsy inflammatory indices with prosthetic joint infection after megaprosthetic reconstruction for osteosarcoma

İbrahim Halil Demir(Gaziantep City Hospital)0000-0002-7572-7285
Mustafa Onur Karaca(ANKARA UNIVERSITY, ANKARA FACULTY OF MEDICINE)0000-0003-0783-510X
Mustafa Özyıldıran(Sandıklı State Hospital)0000-0002-2187-9267
Onur Kaya(Gaziantep City Hospital)0000-0002-7164-3156
İdris Perktaş(Gaziantep City Hospital)0009-0005-4582-1560
Hüseyin Yusuf Yıldız(ANKARA UNIVERSITY, ANKARA FACULTY OF MEDICINE)0000-0002-7669-6206
Sayfa
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Yayın Tarihi
2026-09-19
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Given the small number of events, these findings should be considered hypothesis-generating and require validation in larger, prospective, multicentre cohorts before clinical application.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Aims: Prosthetic joint infection (PJI) is a challenging disease associated with substantial patient disability and high treatment costs.
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Temel Bulgular & Veri:Methods: This retrospective study included 48 patients with osteosarcoma who underwent neoadjuvant chemotherapy followed by resection prosthesis at a tertiary care centre between January 2020 and October 2023.
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Sonuç & Katkı:Given the small number of events, these findings should be considered hypothesis-generating and require validation in larger, prospective, multicentre cohorts before clinical application.
🔬Tür:Research Article
📍Kapsam:2020 Verileri
⚙️Değişkenler:Prosthetic joint infection · PJI · inflammatory indices

Abstract

Aims: Prosthetic joint infection (PJI) is a challenging disease associated with substantial patient disability and high treatment costs. This study aimed to evaluate the association between inflammatory markers measured in pre-biopsy blood samples and PJI in patients with osteosarcoma. Methods: This retrospective study included 48 patients with osteosarcoma who underwent neoadjuvant chemotherapy followed by resection prosthesis at a tertiary care centre between January 2020 and October 2023. PJI was observed in 7 patients (14.6%) during the 12-month follow-up period, and the diagnosis was established in accordance with the 2018 Musculoskeletal Infection Society criteria. Blood samples collected before biopsy were analyzed for a comprehensive set of inflammatory markers, including white blood cell count, erythrocyte sedimentation rate, C-reactive protein, mean platelet volume, red blood cell distribution width, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), Systemic Immune-Inflammation Index (SII), Systemic Inflammation Response Index (SIRI), and pan-immune-inflammation value. Results: PJI occurred in 7 patients (14.6%), while 41 patients (85.4%) did not develop PJI. There were no significant differences between the two groups in terms of age, body-mass index, gender, affected extremity, or prosthesis location (p>0.05). Patients with PJI had significantly higher NLR (3.9±0.8 vs. 2.0±0.7, p 570.6 was associated with PJI, with a sensitivity of 100% and specificity of 97.6% (AUC 0.979, 95% CI 0.889-0.999; p<0.001). Conclusion: Pre-biopsy blood levels of NLR, PLR, SII, SIRI, and PIV were significantly associated with PJI in patients undergoing limb-sparing resection and prosthetic reconstruction for osteosarcoma; PIV and NLR showed the highest apparent sensitivity and specificity, without a significant difference between them. Given the small number of events, these findings should be considered hypothesis-generating and require validation in larger, prospective, multicentre cohorts before clinical application.

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Bu Makaleye Atıf Yap

Demir, İ. H., Karaca, M. O., Özyıldıran, M., Kaya, O., Perktaş, İ., Yıldız, H. Y. (2026). Association of pre-biopsy inflammatory indices with prosthetic joint infection after megaprosthetic reconstruction for osteosarcoma. Journal of Health Sciences and Medicine, Volume: 9 Issue: 5. https://doi.org/10.32322/jhsm.1963531

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