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Dergiler / Hacettepe Üniversitesi Eczacılık Fakültesi Dergisi / 2023 / Volume: 43 Issue: 4

Effects of the Aronia Melanocarpa extract action on the activity of mitochondrial creatine kinase under immobilization stress in old rats

Volodymyr Shvets(Zaporizhzhia State Medical University)0000-0002-9751-4926
Hanna Maslak(Dnipro State Medical University)0000-0003-3573-8606
Vadim Davydov(Institute of Children and Adolescents Health Care, National Academy of Medical Sciences of Ukraine)0000-0002-3347-1832
Halyna Berest(Zaporizhzhia State Medical University)0000-0001-6718-1713
Inna Nosulenko(Zaporizhzhia State Medical University)0000-0002-8725-7321
Oleksii Voskoboinik(National University "Zaporizhzhia Polytechnic")0000-0002-5790-3564
Liudmyla Omelianchyk(Zaporizhzhia National University)0000-0001-7414-4267
Oleksandr Brazhko(Zaporizhzhia National University)0000-0002-5212-2689
Sayfa
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Yayın Tarihi
2023-12-01
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Yapay Zeka Hızlı Bakış & Çıkarımlar

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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Thus, the extract of Aronia melanocarpa increases the myocardial resistance to the injury effect of stress.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:The effects of the Aronia melanocarpa extract on mitochondrial creatine kinase isoenzyme of the old rats heart under stress were studied.
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Temel Bulgular & Veri:The research was performed on 30 male rats of the Wistar line.
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Sonuç & Katkı:Thus, the extract of Aronia melanocarpa increases the myocardial resistance to the injury effect of stress.
🔬Tür:Research Article
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:stress · myocardium · aging

Özet

The effects of the Aronia melanocarpa extract on mitochondrial creatine kinase isoenzyme of the old rats heart under stress were studied. The research was performed on 30 male rats of the Wistar line. For expiriment were used old (22–25 months) animals. It was established, that the injection of the extract (Aronia melanocarpa) at a dose of 0.2 g/kg 60 minutes before the immobilization has limited sensitivity of the heart muscle’s CPK-MT to damaging stress factors (reduced medium pH, increased medium tonicity, increased concentration of calcium, activated free radical processes), and helps the normalization of its kinetic properties, has an influence on the myocardium’s kinetic supply. Thus, the extract of Aronia melanocarpa increases the myocardial resistance to the injury effect of stress.

Abstract

The effects of the Aronia melanocarpa extract on mitochondrial creatine kinase isoenzyme of the old rats heart under stress were studied. The research was performed on 30 male rats of the Wistar line. For expiriment were used old (22–25 months) animals. It was established, that the injection of the extract (Aronia melanocarpa) at a dose of 0.2 g/kg 60 minutes before the immobilization has limited sensitivity of the heart muscle’s CPK-MT to damaging stress factors (reduced medium pH, increased medium tonicity, increased concentration of calcium, activated free radical processes), and helps the normalization of its kinetic properties, has an influence on the myocardium’s kinetic supply. Thus, the extract of Aronia melanocarpa increases the myocardial resistance to the injury effect of stress.

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Bu Makaleye Atıf Yap

Shvets, V., Maslak, H., Davydov, V., Berest, H., Nosulenko, I., Voskoboinik, O., Omelianchyk, L., Brazhko, O. (2023). Effects of the Aronia Melanocarpa extract action on the activity of mitochondrial creatine kinase under immobilization stress in old rats. Hacettepe Üniversitesi Eczacılık Fakültesi Dergisi, Volume: 43 Issue: 4. https://doi.org/10.52794/hujpharm.1269999

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