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Dergiler / Fırat Üniversitesi Fen Bilimleri Dergisi / 2026 / Cilt: 30 Sayı: 1

Avrupa Yayın Balığı (Silurus glanis L.)'nın Sindirim Kanalındaki Bazı Nöropeptidlerin İmmunohistokimyasal Olarak İncelenmesi

Sibel Köprücü
Mine Yaman
Sayfa
15–21
Yayın Tarihi
2018-03-01
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Ekonomik öneme sahip olan Silurus glanis’in sindirim kanalında bu immunoreaktivitelerin ilk defa belirlenmiş olması, bu balığın kas ve mukosal salgı aktivitesinin morfolojik ve fonksiyonel yönden değerlendirilmesine katkı sağlamaktadır.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:İmmunohistokimyasal teknikler kullanılarak Avrupa yayın balığı Silurus glanis’in mide ve bağırsağında gastrin, glukagon ve kolesistokinin (CCK-8) belirlendi.
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Temel Bulgular & Veri:Bu nöropeptidler mide ve bağırsağın farklı bölümlerinde değişen yoğunluk ve lokalizasyonda tespit edildi.
💡
Sonuç & Katkı:Ekonomik öneme sahip olan Silurus glanis’in sindirim kanalında bu immunoreaktivitelerin ilk defa belirlenmiş olması, bu balığın kas ve mukosal salgı aktivitesinin morfolojik ve fonksiyonel yönden değerlendirilmesine katkı sağlamaktadır.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Silurus glanis L. · İmmunohistokimya · Sindirim kanalı

Özet

İmmunohistokimyasal teknikler kullanılarak Avrupa yayın balığı Silurus glanis’in mide ve bağırsağında gastrin, glukagon ve kolesistokinin (CCK-8) belirlendi. Bu nöropeptidler mide ve bağırsağın farklı bölümlerinde değişen yoğunluk ve lokalizasyonda tespit edildi. Gastrin ve glukagon immunoreaktiviteleri midenin gastrik mukozasında belirlendi. Bu immureaktif hücreler genellikle midenin yüzey ve bez epitel hücreleri arasında lokalizedir. Gastrin, glukagon ve CCK-8 immunoreaktiviteleri bağırsakta bulundu. Bağırsak mukozasındaki immunoreaktif hücreler yüzey epitel hücrelerinde belirlendi. Ekonomik öneme sahip olan Silurus glanis’in sindirim kanalında bu immunoreaktivitelerin ilk defa belirlenmiş olması, bu balığın kas ve mukosal salgı aktivitesinin morfolojik ve fonksiyonel yönden değerlendirilmesine katkı sağlamaktadır.

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Bu Makaleye Atıf Yap

Köprücü, S., Yaman, M. (2018). Avrupa Yayın Balığı (Silurus glanis L.)'nın Sindirim Kanalındaki Bazı Nöropeptidlerin İmmunohistokimyasal Olarak İncelenmesi. Fırat Üniversitesi Fen Bilimleri Dergisi, Cilt: 30 Sayı: 1, 15–21. https://ajindex.com/articles/1484057

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Kaynakça (58)

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  2. Pan QS, Fang ZP, Huang FJ (2000a). Identification, localization and morphology of APUD cells in gastroenteropancreatic system of stomach-containing teleosts. World Journal of Gastroenterology, 6(6):842-847
  3. Groff KE, John HY (1997). An immunohistochemical study of the endocrine cells within the pancreas, intestine, and stomach of the gar (Lepisosteus osseus L.). General and Comparative Endocrinology, 106: 1–6
  4. Solcia E, Capella C, Buffa R (1987). Endocrine cells of the digestive system. In: Johnson LR, ed. Physiology of the gastrointestinal tract. New York. Raven Press. 111p
  5. Sherwood NM, Kruecke SL, Mcrory JE (2000). The origin and function of the pituitary adenylate cyclase-activating polypeptide (PACAP)/glucagon superfamily. Endocrine Reviews, 21: 619–670
  6. Wren AM, Small CJ, Abbott CR, Dhillo WS, Seal LJ, Cohen MA, Batterham RL, Taheri S,Stanley SA, Ghatei MA, Bloom SR (2001). Ghrelin causes hyperphagia and obesity in rats. Diabetes, 50: 2540–2547
  7. Peyon P, Lin XW, Himick BA, Peter RE (1998). Molecular cloning and expression of cDNA encoding brain preprocholecystokinin in goldfish. Peptides, 19:199–210
  8. Pan QS, Fang ZP, Zhao YX (2000b). Immunocytochemical identification and localization of APUD cells in the gut of seven stomachless teleost fishes. World Journal of Gastroenterology, 6: 96-101
  9. Çınar K, Diler A (2002). Immunohistochemical localization of glucagon, sunstance-P, and vasoactive intestinal peptide in gastrointestinal tract mucosa of zander. Journal of Fish Biology, 60: 319–327
  10. Kurokawa T, Suzuki T, Hashimoto H (2003). Identification of gastrin and multiple cholecystokinin genes in teleost. Peptides, 24: 227–235
  11. Bosi G, Giancamillo AD, Arrighi S, Domeneghini C (2004a). An immunohistochemical study on the neuroendocrine system in the alimentary canal of the Brown trout, Salmo trutta, L., 1758. General and Comparative Endocrinology, 138: 166–181
  12. Lee JH, Ku SK, Park KD, Lee HS (2004). Immunohistochemical study of the gastrointestinal endocrine cells in the Korean aucha perch. Journal of Fish Biology, 65(1): 170–181
  13. Min HE, Wang K, Zhang Y (2009). Immunocytochemical Identification and Localization of Diffuse Neuroendocrine System (DNES) Cells in Gastrointestinal Tract of Channel Catfish (Ictalurus punctatus). Agricultural Sciences in China, 8(2): 238-243
  14. Kuru N, Çınar K, Şenol N, Demirbağ E, Diler D (2010). Endocrine Cells in the Gastrointestinal Tract of Garra rufa. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 16 (Suppl-B): 235–241
  15. Vigliano FA, Munoz L, Hernandez D, Cerutti P, Bermudez R, Quiroga MI (2011). An immunohistochemical study of the gut neuroendocrine system in juvenile pejerrey Odontesthes bonariensis (Valenciennes). Journal of Fish Biology, 78: 901–911
  16. Hernandez DR, Vigliano FA, Sanchez S, Bermudez R, Domitrovic HA, Quiroga MI (2012). Neuroendocrine system of the digestive tract in Rhamdia quelen juvenile: an immunohistochemical study. Tissue and Cell, 44: 220–226
  17. Pereira RT, Costa LS, Oliveira IRC, Araujo JC, Aerts M, Vigliano PV (2015). Rosa Relative distribution of gastrin-, CCK-8-, NPY- and CGRP-immunoreactive cells in the digestive tract of dorado (Salminus brasiliensis) Tissue and Cell, 47: 123–131
  18. Lin X, Wang P, Ou Y, Li1 J, Wen J (2017). An immunohistochemical study on endocrine cells in the neuroendocrine system of the digestive tract of milkfish Chanos chanos (Forsskal, 1775). Aquaculture Research, 48: 1439–1449
  19. Ku SK, Lee JH, Lee HS (2004). Immunohistochemical study on the endocrine cells in the gut of the stomachless teleost, Zacco platypus (cyprinidae). Anatomia Histologia Embryologia, 33: 212–219
  20. Bosi G, Shinn AP, Giari L, Simoni F, Dezfuli BS (2005). Changes in the neuromodulators of the diffuse endocrine system of the alimentary canal of farmed rainbow trout, Oncorhynchus mykiss (Walbaum), naturally infected with Eubothrium crassum (Cestoda). Journal of Fish Diseases, 28: 703–711
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  23. Bjenning C, Holmgren S, (1988). Neuropeptides in the fish gut. An immunohistochemical study of evolutionary patterns. Histochemistry, 88: 155–163
  24. Ping HC, Feng K, Zhang GR, Wei KJ, Zou GW, Wang WM (2014). Ontogeny expression of ghrelin, neuropeptide Y and cholecystokinin in blunt snout bream, Megalobrama amblycephala. Journal of Animal Physiology and Animal Nutrition 98: 338–346
  25. Hur SW, Lee CH, Lee SH, Kim BH, Kim HB, Baek HJ, Lee YD (2013). Characterization of cholecystokinin-producing cells and mucus-secreting goblet cells in the blacktip grouper, Epinephelus fasciatus. Tissue and Cell 45: 153–157
  26. Gençer TB, Bayrakdar A. Yaman M (2012). Immunohistochemical study of the endocrine cells in the stomach and pyloric caeca of the mountain trout, Salmo trutta macrostigma. Iranian Journal of Fisheries Sciences 11(4): 776-785
  27. Şenol N, Çınar K, Eren Ü (2009). Sudak (Stizostedion Lucioperca L., 1758) Balığında Mide ve Bağırsakta Bazı Peptidlerin Lokalizasyonu. Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi (e-dergi), 4(2): 136-150
  28. Diler D, Çınar K, Zorlu S (2011). An Immunohistochemical Study on the Endocrine Cells in the Stomach and Intestine Regions of the Dicentrarchus labrax, L.,1758. Fırat Üniversitesi Sağlık Bilimleri Dergisi, 25 (1): 01 – 06
  29. Jensen J (2001). Regulatory peptides and control of food intake in non-mammalian vertebrates. Comparative Biochemistry and Physiology, 128: 471–479
  30. Linhart O, Setch L, Svarc J, Rodina M, Audebert JP, Grecu J, Billard R (2002). The culture of the European catfish, Silurus glanis, in the Czech Republic and in France. Aquatic Living Resources, 15: 139–144
  31. Pan QS, Fang ZP, Huang FJ (2000a). Identification, localization and morphology of APUD cells in gastroenteropancreatic system of stomach-containing teleosts. World Journal of Gastroenterology, 6(6):842-847
  32. Groff KE, John HY (1997). An immunohistochemical study of the endocrine cells within the pancreas, intestine, and stomach of the gar (Lepisosteus osseus L.). General and Comparative Endocrinology, 106: 1–6
  33. Solcia E, Capella C, Buffa R (1987). Endocrine cells of the digestive system. In: Johnson LR, ed. Physiology of the gastrointestinal tract. New York. Raven Press. 111p
  34. Sherwood NM, Kruecke SL, Mcrory JE (2000). The origin and function of the pituitary adenylate cyclase-activating polypeptide (PACAP)/glucagon superfamily. Endocrine Reviews, 21: 619–670
  35. Wren AM, Small CJ, Abbott CR, Dhillo WS, Seal LJ, Cohen MA, Batterham RL, Taheri S,Stanley SA, Ghatei MA, Bloom SR (2001). Ghrelin causes hyperphagia and obesity in rats. Diabetes, 50: 2540–2547
  36. Peyon P, Lin XW, Himick BA, Peter RE (1998). Molecular cloning and expression of cDNA encoding brain preprocholecystokinin in goldfish. Peptides, 19:199–210
  37. Pan QS, Fang ZP, Zhao YX (2000b). Immunocytochemical identification and localization of APUD cells in the gut of seven stomachless teleost fishes. World Journal of Gastroenterology, 6: 96-101
  38. Çınar K, Diler A (2002). Immunohistochemical localization of glucagon, sunstance-P, and vasoactive intestinal peptide in gastrointestinal tract mucosa of zander. Journal of Fish Biology, 60: 319–327
  39. Kurokawa T, Suzuki T, Hashimoto H (2003). Identification of gastrin and multiple cholecystokinin genes in teleost. Peptides, 24: 227–235
  40. Bosi G, Giancamillo AD, Arrighi S, Domeneghini C (2004a). An immunohistochemical study on the neuroendocrine system in the alimentary canal of the Brown trout, Salmo trutta, L., 1758. General and Comparative Endocrinology, 138: 166–181
  41. Lee JH, Ku SK, Park KD, Lee HS (2004). Immunohistochemical study of the gastrointestinal endocrine cells in the Korean aucha perch. Journal of Fish Biology, 65(1): 170–181
  42. Min HE, Wang K, Zhang Y (2009). Immunocytochemical Identification and Localization of Diffuse Neuroendocrine System (DNES) Cells in Gastrointestinal Tract of Channel Catfish (Ictalurus punctatus). Agricultural Sciences in China, 8(2): 238-243
  43. Kuru N, Çınar K, Şenol N, Demirbağ E, Diler D (2010). Endocrine Cells in the Gastrointestinal Tract of Garra rufa. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 16 (Suppl-B): 235–241
  44. Vigliano FA, Munoz L, Hernandez D, Cerutti P, Bermudez R, Quiroga MI (2011). An immunohistochemical study of the gut neuroendocrine system in juvenile pejerrey Odontesthes bonariensis (Valenciennes). Journal of Fish Biology, 78: 901–911
  45. Hernandez DR, Vigliano FA, Sanchez S, Bermudez R, Domitrovic HA, Quiroga MI (2012). Neuroendocrine system of the digestive tract in Rhamdia quelen juvenile: an immunohistochemical study. Tissue and Cell, 44: 220–226
  46. Pereira RT, Costa LS, Oliveira IRC, Araujo JC, Aerts M, Vigliano PV (2015). Rosa Relative distribution of gastrin-, CCK-8-, NPY- and CGRP-immunoreactive cells in the digestive tract of dorado (Salminus brasiliensis) Tissue and Cell, 47: 123–131
  47. Lin X, Wang P, Ou Y, Li1 J, Wen J (2017). An immunohistochemical study on endocrine cells in the neuroendocrine system of the digestive tract of milkfish Chanos chanos (Forsskal, 1775). Aquaculture Research, 48: 1439–1449
  48. Ku SK, Lee JH, Lee HS (2004). Immunohistochemical study on the endocrine cells in the gut of the stomachless teleost, Zacco platypus (cyprinidae). Anatomia Histologia Embryologia, 33: 212–219
  49. Bosi G, Shinn AP, Giari L, Simoni F, Dezfuli BS (2005). Changes in the neuromodulators of the diffuse endocrine system of the alimentary canal of farmed rainbow trout, Oncorhynchus mykiss (Walbaum), naturally infected with Eubothrium crassum (Cestoda). Journal of Fish Diseases, 28: 703–711
  50. Stenberger LA, (1986), Immunocytochemistry. 3rd ed. Wiley, New York
  51. Shu S, Ju G, Fan L (1988). The glucose oxidase-DAB-nickel method in peroxidase histochemistry of the nervous system. Neuroscience Letters, 85: 169-171
  52. Bjenning C, Holmgren S, (1988). Neuropeptides in the fish gut. An immunohistochemical study of evolutionary patterns. Histochemistry, 88: 155–163
  53. Ping HC, Feng K, Zhang GR, Wei KJ, Zou GW, Wang WM (2014). Ontogeny expression of ghrelin, neuropeptide Y and cholecystokinin in blunt snout bream, Megalobrama amblycephala. Journal of Animal Physiology and Animal Nutrition 98: 338–346
  54. Hur SW, Lee CH, Lee SH, Kim BH, Kim HB, Baek HJ, Lee YD (2013). Characterization of cholecystokinin-producing cells and mucus-secreting goblet cells in the blacktip grouper, Epinephelus fasciatus. Tissue and Cell 45: 153–157
  55. Gençer TB, Bayrakdar A. Yaman M (2012). Immunohistochemical study of the endocrine cells in the stomach and pyloric caeca of the mountain trout, Salmo trutta macrostigma. Iranian Journal of Fisheries Sciences 11(4): 776-785
  56. Şenol N, Çınar K, Eren Ü (2009). Sudak (Stizostedion Lucioperca L., 1758) Balığında Mide ve Bağırsakta Bazı Peptidlerin Lokalizasyonu. Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi (e-dergi), 4(2): 136-150
  57. Diler D, Çınar K, Zorlu S (2011). An Immunohistochemical Study on the Endocrine Cells in the Stomach and Intestine Regions of the Dicentrarchus labrax, L.,1758. Fırat Üniversitesi Sağlık Bilimleri Dergisi, 25 (1): 01 – 06
  58. Jensen J (2001). Regulatory peptides and control of food intake in non-mammalian vertebrates. Comparative Biochemistry and Physiology, 128: 471–479.