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Dergiler / Experimental and Applied Medical Science / 2023 / Cilt: 4 Sayı: 4

Antioxidative Strategy in Traumatic Brain Injury: Role of Low-Molecular-Weight Antioxidants

Ibrahim Bulama(University of Maiduguri)
Umar Faruk Saidu(Usmanu Danfodiyo University)0000-0002-4048-9627
Nasiru Suleiman(Usmanu Danfodiyo University)
Abdullahi Abbas(Usmanu Danfodiyo University)0000-0001-7466-721X
Yusuf Saidu(Usmanu Danfodiyo University)0000-0002-8372-9379
Yusuf Yakubu(Usmanu Danfodiyo University)0000-0002-7789-727X
Nasiru Jinjiri(Usmanu Danfodiyo University)0000-0002-7166-5734
Lawal Bilbis(Usmanu Danfodiyo University)0000-0002-6917-4880
Sayfa
573–594
Yayın Tarihi
2024-02-12
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

However, further studies should investigate the molecular mechanisms of these antioxidants on TBI pathophysiology and functional outcome.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Objective: Traumatic brain injury (TBI) is a major cause of mortality and disability worldwide.
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Temel Bulgular & Veri:A total of 70 Rats was used and were divided into 12 treatment groups, a traumatized non-treated group (TNT) and a Non-traumatized non-treated group (NTNT).
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Sonuç & Katkı:However, further studies should investigate the molecular mechanisms of these antioxidants on TBI pathophysiology and functional outcome.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Traumatic brain injury · Oxidative Stress · Neurological score

Abstract

Objective: Traumatic brain injury (TBI) is a major cause of mortality and disability worldwide. This study was designed to investigate the beneficial and neuroprotective role of some Low-Molecular-Weight antioxidants (LMWA) in the treatment of TBI in albino rats. Methods: TBI was induced in adult albino rats using the weight-drop method. A total of 70 Rats was used and were divided into 12 treatment groups, a traumatized non-treated group (TNT) and a Non-traumatized non-treated group (NTNT). There were 5 rats per group. Each of the treatment groups received 22.5 or 45 mg/kg of dimethyl sulfoxide (DMSO), Alpha Lipoic acid (ALA), Uric acid (UA), vitamin C (VC), vitamin E (VE), or Mannitol. Treatment was started 30 min after the trauma and continued for 21 days. To evaluate the functional outcomes, the modified neurological severity score (mNSS) was calculated. The antioxidant enzymes [superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx)], and malondialdehyde (MDA) were assayed to evaluate oxidative stress (OS). Results: At 7 days post-TBI, the antioxidant-treated groups exhibited significant (p<0.05) improvements in neurological scores compared to the traumatized non-treated group (TNT). The treated groups showed a significant (p<0.05) increase in the activities of antioxidant enzymes (SOD, CAT and GPx) and a significant (p<0.05) decrease in the concentration of MDA compared with the TNT group. Conclusion: These promising results suggest that the use of low-molecular-weight antioxidants may be a useful neuroprotective strategy in the treatment of TBI. However, further studies should investigate the molecular mechanisms of these antioxidants on TBI pathophysiology and functional outcome.

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Bu Makaleye Atıf Yap

Bulama, I., Saidu, U. F., Suleiman, N., Abbas, A., Saidu, Y., Yakubu, Y., Jinjiri, N., Bilbis, L. (2024). Antioxidative Strategy in Traumatic Brain Injury: Role of Low-Molecular-Weight Antioxidants. Experimental and Applied Medical Science, Cilt: 4 Sayı: 4, 573–594. https://doi.org/10.46871/eams.1346139

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